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Feb 12 • 6 tweets • 2 min read
The findings of this one suggest that acutely prolonging an overnight fast may improve overnight substrate oxidation, and that these alterations are not mediated by changes in hepatic glycogen depletion.
- Acutely prolonging an overnight fast reduced carbohydrate oxidation and increased fat oxidation during the night in both individuals with NAFLD and healthy control participants.
- Despite fasting for 16 hours, the overnight carbohydrate oxidation of the group with NAFLD stayed relatively high compared with carbohydrate oxidation of the control group.
- However, no statistically significant changes in overnight hepatic glycogen depletion were observed.
- These results suggest that a prolonged fast can improve overnight substrate oxidation, but that this improvement is not mediated by changes in hepatic glycogen depletion.
A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial (open access)

doi.org/10.1002/oby.23…

#fasting #IntermittentFasting #MetabolicSyndrome

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More from @nick_krontiris

Nick Krontiris Profile picture
Feb 14
In this one, a higher adherence to the American Heart Association’s Life’s Essential 8 cardiovascular health score was found to be associated with lower risks of all-cause and cardiovascular mortality among US adults. ImageImage
- The American Heart Association’s Life’s Essential 8 cardiovascular health score consists of 8 modifiable metrics: physical activity, diet, smoking status, BMI, systolic blood pressure, fasting plasma glucose, cholesterol, and sleep.

heart.org/en/healthy-liv…
- A higher LE8 score was independently associated with lower mortality risk from all-cause and cardiovascular diseases.
Read 5 tweets
Nick Krontiris Profile picture
Feb 13
In this one, adipsin, an adipokine that can stimulate triglyceride synthesis and is involved in the complement system, was found to be associated with MAFLD.
- Individuals with MAFLD had higher levels of adipsin.
- In indivisuals with MAFLD, as the number of metabolic risk abnormalities increased, the levels of serum adipsin and the proportion of moderate to severe fatty liver disease also increased.
Read 4 tweets
Nick Krontiris Profile picture
Feb 12
Interestingly, this one found both low and high glycaemic levels as well as low and high levels of HbA1c to be associated with an increased risk of infection-related mortality risk.
- In this large cohort study of young and middle-aged Korean adults, diabetes, non-diabetic hyperglycaemia and insulin resistance were associated with increased risk of infection-related mortality.
- These associations remained significant after adjustment for potential confounders and when changes in glycaemic parameters and confounders over time were incorporated as time-varying covariates.
Read 6 tweets
Nick Krontiris Profile picture
Feb 12
This systematic review and meta-analysis suggests that even though both HIIT and Moderate-Intensity Continuous Training can improve glucose metabolism in the elderly, HIIT is probably superior.
- This systematic review and meta-analysis, aimed to identify the effects of MICT and HIIT on the glycemic control of older people with glucose metabolism impairments.
- Only six papers met the inclusion criteria.
Read 6 tweets
Nick Krontiris Profile picture
Feb 12
In this one, sedentary older adults residing in the United States with higher visceral adipose tissue and greater total sleep time were more likely to have brains that were physiologically older than would have been expected based upon chronological age alone.
- To provide a more comprehensive analysis of age-related changes to brain structure, new tools that leverage the capacity of machine learning algorithms have emerged.
- Commonly considered a way to determine the physiological age of the brain, these tools utilize regional brain measures from MRI acquired from large samples who range widely in age to calculate a biological brain age.
Read 7 tweets
Nick Krontiris Profile picture
Feb 12
The findings of this one suggest that secreted adipocyte-derived extracellular vesicles can inform pancreatic β-cells about insulin resistance in adipose tissue in order to amplify glucose-stimulated insulin secretion in times of increased insulin demand.
- Recent findings suggest that white adipose tissue-derived extracellular vesicles play an important role in the onset of insulin resistance and glucose intolerance.
- This study provides evidence that adipocyte-derived extracellular vesicles serve as a signaling entity that can amplify insulin secretion in pancreatic β-cells.
Read 7 tweets

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