NextMed.Health - pricey $$$$ in person but streaming live free of charge! Join now:
https://twitter.com/NextMedHealth/status/1630233779376885761
Direct link to streaming and agenda: nextmed.health/live
@NextMedHealth agenda Mar 13-16 (times in PT): files.elfsightcdn.com/eafe4a4d-3436-…
3/ 
4/ Future applications of AI
5/ AI limitations
6/ AI: We don't wanna create chemical weapons, and we don't wanna perpetuate problems of the current medical system -> Do no harm & pay down tech debt
7/ On Web3 in healthcare
8/ ChatGPT is just a tip of the iceberg. We need a highly decentralized approach.
9/ From web 1 to web 3
10/ On decenralized science. Massive transformation is happening in the science space.
11/ How o we take AI to decentralized data? Aggregation, mining, reward, interact. True anonymity, not just pseudoanonymity.
12/ Pseudoanonymity -> privacy tech.
Utility vs. privacy.
Tradeoff as you go to the right.
Federated Learning & Split Learning
Utility vs. privacy.
Tradeoff as you go to the right.
Federated Learning & Split Learning
13/ Every hospital can create local AI, but those are imprecise. (What works on children may not work on elderly. What works on smokers may not work on nonsmokers) -> creating collective intelligence
14/
15/ HealthUX.
Friction in EHR (e.g. patient matching - recognizing correct patient when multiple have the same name)
Decentralized science and AI
Friction in EHR (e.g. patient matching - recognizing correct patient when multiple have the same name)
Decentralized science and AI
16/ More on decentralized society w/ web 3 - see the QR code
17/ Surgeon and XR enthusiast @ZGJR is now on stage at @NextMedHealth. Join livestream here: nextmed.health/live
18/ Augmented Relity (AR) - Mixed reality (MR) - Virtual reality (VR)
Hololens
Multi-user experience from different geographical locations
Hololens
Multi-user experience from different geographical locations
19/ Learn how to diagnose etc. from extended reality. Multiuser training.
Sensory integration including haptics
Cost has been decreasing
Sensory integration including haptics
Cost has been decreasing
20/ Platform: must be multi-player, scalable, AI powered, cost-effective
Haptics glove helps you feel what you're touching to make it more real.
Haptics glove helps you feel what you're touching to make it more real.
21/ VR: can smell (e.g. while learning to make pizza).
Strong potential: PTSD and smelling powder
Manipulate data real time in 3D
Improving flow and experience in a surgery
Strong potential: PTSD and smelling powder
Manipulate data real time in 3D
Improving flow and experience in a surgery
22/ Bringing anatomically correct images to EMR
23/ Blue pill or red pill? ;)
24/ Q (@daniel_kraft): Who can be a surgeon w/ the new technology?🤔
A (@ZGJR): Technology can bring education to anywhere anytime in a cost effective way to anywhere in the world...
A (@ZGJR): Technology can bring education to anywhere anytime in a cost effective way to anywhere in the world...
26/ Chris Wigley on genomics
Sequenced kiddo Jessica (4yo) and both parents to get an effective treatment.
Sequenced kiddo Jessica (4yo) and both parents to get an effective treatment.
27/ Population health study. Clinical reasons to be using whole genome studies: many patients not diagnosed through other means
28/ Massive proof of concept study for genomics in healthcare
Numerous partners
Numerous partners
29/ Whole genome sequencing. Green: piloting, trying to bring into clinic. Scicence -> pilots -> innovation -> clinical care
30/ Productivity challenges. Appmnts can be reduced. Finding right therapeutics for cancer patients.
Like acquarium: study but don't take it out.
Only valuable when joined w/ other modalities.
Scanning & digitizing data from cancer patients -> the largest dataset of its kind
Like acquarium: study but don't take it out.
Only valuable when joined w/ other modalities.
Scanning & digitizing data from cancer patients -> the largest dataset of its kind
31/ Kiddo w/ inconclusive tests. Genom determined that his tumor was benign.
32/ They have the lead scientists to lead the discoveries
33/ Lifelong relationship w/ the genome: how can that accelerate the right treatment?
E.g.
Teenager: mental health
Later: neurodegenerative diseases
E.g.
Teenager: mental health
Later: neurodegenerative diseases
34/ Genomics England to transform lives on scales and demonstrate the concept
35/ Andrew Hessel on Synthetic Biology: Rewriting Life.
= intersection of life science, computation and automation
= intersection of life science, computation and automation
36/ DNA sequencing cost is outpacing Moore's Law
27/ Identify which dog has been pooping on your lawn 😂💩🐕🦺
28/ Numerous applications: anything that touches life, including degradable plastics....
29/ Positive feedback loop.
AI tools to design proteins.
Labs are becoming automated.
AI tools to design proteins.
Labs are becoming automated.
40/ Protein engineering.
Can grow cells on chips and train it to play pong.
Will be able to engineer vectors and viruses.
Kill cancer cell... -> treat cancel in an individualized way
Cancer vaccines for patients.
Can grow cells on chips and train it to play pong.
Will be able to engineer vectors and viruses.
Kill cancer cell... -> treat cancel in an individualized way
Cancer vaccines for patients.
41/ We'll need bigger investment in biosecurity.
Extinction...
Can we stop aging, or even become immortal?
Extinction...
Can we stop aging, or even become immortal?
43/ Will our bedrooms look like this in 20-30 yrs?
44/ On new frontiers in women's health. Female animals and humans were not included in clinical trieals until quite recently. It's also a funding problem.
45/ #Ovaries age 2.5x faster than the rest of the body -> puts #women in distinct disadvantage. Ovarian health is very important for overall women health.
46/ 1000 eggs are lost month, 1 of which may or may not get fertilized.
Line between puberty and menopause: if we can change theat -> can change how women age -> @OvivaTx
Hormonal changes associated w/ #menopause speed up cellular aging by 6%
Line between puberty and menopause: if we can change theat -> can change how women age -> @OvivaTx
Hormonal changes associated w/ #menopause speed up cellular aging by 6%
47/ Women w/ later menopause tend to live longer.
48/ Eternal fertility in naked mole rats
49/ #AMH
Regulates how often and how many eggs released to maturation pathway
-> can regulate the pace at which we deplete the ovarian reserves?
Regulates how often and how many eggs released to maturation pathway
-> can regulate the pace at which we deplete the ovarian reserves?
50/ Possible fertility and IFV help.
Can double # (ovulated?) eggs w/o reducing quality
Validating - lots of info we don't know. Humans aren't rodents.
Can double # (ovulated?) eggs w/o reducing quality
Validating - lots of info we don't know. Humans aren't rodents.
51/ Goals: Learn more about women's (ovarian) health. Raise awareness. Uncover unanswered questions. Train docs better.
Ultimately: give women choice!
Learn more on @OvivaTx website.
Ultimately: give women choice!
Learn more on @OvivaTx website.
52/ Mariya Filipova on Systemic Health: healthy patient outcomes communities
Do you think about dentist when we mention overall health? Oral health is overall health! Related to many other health aspects.
Untreated oral health issues -> higher risk of dementia & cognit. decline
Do you think about dentist when we mention overall health? Oral health is overall health! Related to many other health aspects.
Untreated oral health issues -> higher risk of dementia & cognit. decline
53/ Neither painkillers nor antibiotics treat the underlying issue.
🦷Also equity issue: more likely to have
Dental care is outpacing the growth of healthcare costs
🦷Also equity issue: more likely to have
Dental care is outpacing the growth of healthcare costs
54/ Access to florinated water
Toothbrushes: electric prototype from 1937 similar to today's toothbrushes
Patient experiences and outcomes haven't changed much
Toothbrushes: electric prototype from 1937 similar to today's toothbrushes
Patient experiences and outcomes haven't changed much
55/ Providing funding to companies that improve link dental care and link it to overall health.
@vVardisofficial: Peptide that regenerates enamel.
Future: instead of drilling & filling may be able to ("rebuild"?)
@vVardisofficial: Peptide that regenerates enamel.
Future: instead of drilling & filling may be able to ("rebuild"?)
56/ Accelerator w/o giving up equity
57/ 🦷innovative companies examples:
Saliva-based diagnostics to screen for dental cancer early
Future: Connecting medical & dental teams. Coordinated & integrated treatment plan.
Saliva-based diagnostics to screen for dental cancer early
Future: Connecting medical & dental teams. Coordinated & integrated treatment plan.
58/ COmpany w/ enamel regenerating product weren't initially able to get reimbursement b/c there was no code. Recently passed new CDT code. Need collaboration b/w investors, companies and regulators. Their accelerator is accepting applicatoins!
59/ Session 4: Transforming tech & patient voice into empathy, impact & access.
@lucienengelen: "From What's New, to How To"
@lucienengelen: "From What's New, to How To"
60/ Don't fix the hole, reach out to the main tap!
61/ By 2035 we'll have a problem in healthcare
62/ Do we add digital? Or digital first?
It's about user interface, yourself.
If possible, do it yourself, at home, digitally.
It's about user interface, yourself.
If possible, do it yourself, at home, digitally.
63/ Possible new Moore's Law: doubling intelligence in the universe
64/ World's first autonomous robot
65/ "How are you doing?" - "Great! Slept well & have a great EKG!"
66/
67/ Consumer is awakening. The consumer is your patient.
Why aren't we utilizing supermarkets? -> Healthcare meets retail.
Why aren't we utilizing supermarkets? -> Healthcare meets retail.
68/ Maybe we'll have new tech @ retail places
69/ Healthcare is next!
70/ Non-healthcare players in healthcare
71/ Every citizen wil have own data. Better diagnostic and treatment.
72/ Healthcare: delocalized, democratized, digital
73/ Joyce de Ruiter: Patients Included: Agility & Resilience in Times of Change
74/ Wow - thank you Joyce de Ruiter for sharing on your rare disease experience with Usher syndrom related to loss of both vision and hearing
75/ A brief conversation can make a huge difference to a patient.
Always choose words of empowerment.
Wow, Joyce de Ruiter - such an overachiever and an inspirer despite of your diagnosis!
Always choose words of empowerment.
Wow, Joyce de Ruiter - such an overachiever and an inspirer despite of your diagnosis!
76/ PDOH: "Political determinants of health"
Alister Martin: "At the intersection of healthcare, policy & civic engagement"
Alister Martin: "At the intersection of healthcare, policy & civic engagement"
77/ DYI: Voter registration is legal in healthcare settings (as a proof of residency in Massachusets)
"Why aren't you registered to vote?" - "Noone has ever asked me"
"Why aren't you registered to vote?" - "Noone has ever asked me"
78/ Low voter turnout & low life expectancy are correlated
79/ Vote to have perspectives included in politics and when important decisions are being made
80/ Doctor's questions: Do you smoke? Do you drink? Are you registered to vote?
Posters and discharge papers helping patients to vote.
Patient registered to vote -> got home, and also helped her family to register to vote.
Posters and discharge papers helping patients to vote.
Patient registered to vote -> got home, and also helped her family to register to vote.
81/ They helped 80k patients to register to vote, w/ turnout 85% (higher than general population of 66.8%) Most pronounced on low propensity voters.
82/ Voting = SDOH!
They helped w/ HHS & VA
Upcoming 2024 registration -> opportunity to get patients involved in voting! cc @poppy_northcutt
They helped w/ HHS & VA
Upcoming 2024 registration -> opportunity to get patients involved in voting! cc @poppy_northcutt
83/ Physicians voted 9% lower than general population
84/ Healthcare workers can help created democracy and increase # registered voters and voter turnout. More info: vot-er.org
85/ Magical interlude w/ a Robert Strong - commedian & magician
---
Power of Story w/ Dave Zaboski
---
Power of Story w/ Dave Zaboski
86/ @Deloitte folks on stage: Bori Kheyn-Kyeyfets & Simon Gisby on "Platforms & The Reassembly of Care"
Sick care -> health care -> wellness (well care)
Sick care -> health care -> wellness (well care)
87/ Ecosystem focused on us: my healthcare meets
Covid times: we turned healthcare workers into gig workers who can work from another locations!
Platforms will take us from fragmentation to reassembly
Covid times: we turned healthcare workers into gig workers who can work from another locations!
Platforms will take us from fragmentation to reassembly
88/ We'll need a "platform mindset": navigating patients - members - consumers
Fee for service -> value based care
Health systems, med tech, pharma: point solutioning companies are not driving this transformation
$40B flowing VCs -> different diseases => to merge & aggregate
Fee for service -> value based care
Health systems, med tech, pharma: point solutioning companies are not driving this transformation
$40B flowing VCs -> different diseases => to merge & aggregate
89/ How do you balance personalization?
Retina: unique identifier. Who owns "Clear"? Are we willing to give up data w/o knowing who owns the data to save a few min and not to take off our shoes at the airport?
Retina: unique identifier. Who owns "Clear"? Are we willing to give up data w/o knowing who owns the data to save a few min and not to take off our shoes at the airport?
90/ Andrea Kates on Finding Your Next
91/ There is no try. Only do. ☯️
Take concrete steps towards game changing actions.
Take concrete steps towards game changing actions.
92/ Get to the next concrete steps!
93/ Jemie Metzl: The promise and peril of human genome editing.
Author of Hacking Darwin: Genetic Engineering & the Future of Humanity.
Member, WHO expert advisory committee on Human Genome Edicting
Author of Hacking Darwin: Genetic Engineering & the Future of Humanity.
Member, WHO expert advisory committee on Human Genome Edicting
94/ Jamie Metzl predicted that gene editing would happen soon and that it would happen in China
95/ Estimating 13 new genes therapies to be approved this year (2023)
Photo from 3rd international summit on gene editing w/ Victoria Gray - see the attached quote!
These technologies: unlimited potential to "do good"
Photo from 3rd international summit on gene editing w/ Victoria Gray - see the attached quote!
These technologies: unlimited potential to "do good"
96/ Promises:
- Heritable diseases
- Times when we'll be able to treat everything
- Even at or before pre-implanted embryo
- Therapy vs. enhancement: part of the same continuum.
- Expecting discussions: what's ok?
- Living in space? Athletics?
- Heritable diseases
- Times when we'll be able to treat everything
- Even at or before pre-implanted embryo
- Therapy vs. enhancement: part of the same continuum.
- Expecting discussions: what's ok?
- Living in space? Athletics?
97/ Real dangers, fears, origins of covid and book tips
98/ Interconnected ecosystems.
We each have a role.
Let's do what we're doing as ethically as possible.
We each have a role.
Let's do what we're doing as ethically as possible.
100/ Closing keynote from day 1: by legend Leroy Hood Md PhD: "The transition from genomics to phenomics in precision population health"
Why health?
Health started w/ the Greeks.
Using data-driven systems
Blood = window into wellness & disease: Molecules concentration changes
Why health?
Health started w/ the Greeks.
Using data-driven systems
Blood = window into wellness & disease: Molecules concentration changes
101/ 1M person project over 10 yrs
1. Arivale (body) company he co-started
2. Partnering w/ Posit (brain)
3. Gut microbiome
Nearly 30 studies on wellness
1. Arivale (body) company he co-started
2. Partnering w/ Posit (brain)
3. Gut microbiome
Nearly 30 studies on wellness
103/ For most chronic diagnoses (cancer or diabetes): we have subtypes, then we can define nature of the subtype trajectory.
Health: welness - transition - disease
Health: welness - transition - disease
104/ Partners
105/ Will generate at least 1000x more data than initially
Recommendations how to optimize;
EHRs
SDOH
Whole genome analysis
Recommendations how to optimize;
EHRs
SDOH
Whole genome analysis
106/ 2 knowledge graphs:
1. Google (50B nodes such as genes, proteins, gene diseases)
2. Spoke: Smaller (27M) but more details
Creating a digital twin for type 2 diabetes
Context for hyperscale AI
Mechanistic / causal
1. Google (50B nodes such as genes, proteins, gene diseases)
2. Spoke: Smaller (27M) but more details
Creating a digital twin for type 2 diabetes
Context for hyperscale AI
Mechanistic / causal
107/ How to persuade HCP, payer, politician, patient to buy into this?
Solution: prediction & prevention is going to save $Ts
Medical schools skeptical in trying new things.
Innovative healthcare 20module 1yr course for hs students
Upcoming book & documentary on wellness
Solution: prediction & prevention is going to save $Ts
Medical schools skeptical in trying new things.
Innovative healthcare 20module 1yr course for hs students
Upcoming book & documentary on wellness
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