Teaming up again with the great @VerwerftJan to share our experience with #echoCPET in #HFpEF. This hot-of-the-press paper @ESC_Journals demonstrates myriad of opportunities for diagnosis & treatment, far beyond #SGLT2i only. Tweetorial below!
In #HFpEF, early & correct diagnosis are important, #phenotyping is everything. There are a lot of mechanisms for dyspnoea involved
Current @ESC_Journals paper goes one step further: "In patients with confirmed HFpEF or probability >90% according to well-validated HFpEF scores (both are complimentary in our view), why #echoCPET within a dedicated #dyspnoea clinic? What is the impact of findings?"
1. Further diagnostic work-up ! #HFpEF has a lot of mimickers that deserve to be ruled out, in 9/10 patients we searched further for causes of dyspnoea, on average 2 diagnostic exams per patient! #cardiomyopathy#amyloid#CAD#lungdisease
2. Medical treatment changes !
In virtually all patients, one can optimize therapies... We change on average 3 meds! #SGLT2i & #spironolactone are obvious ones, but #hypertension & #lipids should be within targets!
Also, I single out reducing/stopping #betablockers, done in ~60%!
3. Tackle comorbidities in 1 stop !
- Obesity is a treatable disease nowadays: #GLP1agonists, sometimes surgery
- Iron deficiency present in 40% (need more data in #HFpEF for R/, but we do often do provide IV iron)
- Too many patients w #diabetes to leave only to endocrinologists
"Don't blame the patient for not caring for themselves, blame yourself for not taking the action that is necessary"
Pro-active = making a difference together
4. Cardiac interventions !
So much easier to stop betablockers in #HFpEF after #AFib ablation. However, first get the meds right and #decongest proberly, more success!
In selected patients pacing & valvular interventions are useful, but ONLY AFTER getting the other things right!
Do You have a dyspnoea clinic for #HFpEF at your place?
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#hyponatremia in #heartfailure 🟰 mainly dilutional: ➡️Impaired water excretion & extracellular volume expansion!
However, we tend to underestimate the depletional component due to chronic potassium and magnesium losses
➡️Intracellular dehydration
➡️Intracellular sodium shift
Replenishing potassium & magnesium stores alone actually increases serum Na in depletional hyponatremia!
K & Mg go intracellular ➡️Na goes back extracellular
Best K level probably ~4.5 mmol/L
3.5-4.0 mmol/L: K deficit ~ 200 mmol (!), so be aggressive!
Read our latest analysis from the #ADVOR trial @JACCJournals. Deeper dive into the relationship of #natriuresis with decongestion & clinical outcomes after diuretic therapy in acute #heartfailure! Tweetorial below...
From #ADVOR population, we included 462 or 89% of patients with 2 correctly performed consecutive urine collections and urine sodium concentration (UNa) available.
Natriuresis:
- UNa [mmol/L] ~ diuretic efficiency
- Total natriuresis [mmol] ~ ECV & interstitial Na buffer removed
#Acetazolamide, after multivariate adjustment, was strongest predictor of #natriuresis in #ADVOR:
UNa + 16 mmol/L
Total natriuresis +115 mmol
👊 within 2 days !!!
👍 much stronger than effect on urine output itself
What is your take on #vasodilators in acute #HeartFailure? The upcoming November issue of #EHJACVC will bring you a PRO/CON "Vasodilator therapy in acute heart failure revisited"
As our PRO paper was published in advanced access, a sneak preview Tweetorial below...
First some background...
Current @escardio guidelines state (IIb, B): "In patients with AHF and a systolic blood pressure (SBP) >110 mmHg, intravenous vasodilators may be considered as an initial therapy to improve symptoms and reduce congestion."
Only 1 flowchart has them in...
So far, I consider this a fair recommendation... In hyper/normotensive pulmonary oedema, they might be helpful in some cases, with their main benefit a reduced need for (non-)invasive ventilation!
Extremely proud that our journal offers a platform to 3 great clinicians & Twitter educators. I always learn from them...
A strong argument is made to switch mainstream thinking in #AKI away from the fallacious concept of fluid responsiveness in all to a primary assessment of fluid tolerance.
Probably the most important thing I have learned on Twitter: #VExUS
Why do I like #VExUS so much? Because it really changed my everyday practice... Portal vein became part of my standard #echocardiography assessment.
And that's what we want to achieve with this review, offer something directly applicable at your bedside!
For those who can't get enough from #ADVOR, below the promised Tweetorial!
Acetazolamide in acute #HeartFailure w volume overload on background high-dose loop diuretics:
👍Increases diuresis & natriuresis
👍More euvolemia after 3 days & discharge
👍⬇️LOS #ESCCongress#Cardiology
First, the unsung hero's of this trial, done with a little bit over 2 million €, bargain for largest diuretic #RCT ever! @KatrienTartagl2 & her team, with only 3FTE, they ran the most successful trial in #AHF @PieterMartensMD & @JeroenDauw who did most fieldwork
👏
How did we come up with the idea? Actually, cause we all love #physiology. Credits go to Prof. Em. Paul Steels who teached us all how kidneys work. @GLW_UHasselt
65% of sodium is reabsorbed in the proximal tubules, can be up to 85% in #HeartFailure