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Paul Maidowski Profile picture
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Mar 17 • 10 tweets • 7 min read
1. SARS as national security concern.

I simplify.

@Taiwan_CDC kept covid/excess deaths to zero until forced to stop #zerocovid in 2022.

China/PLA can wait for the momentum of chronic disease to take hold within 10-15 years. Taiwan knows; here info sent to citizens today alone. ImageImageImageImage
@Taiwan_CDC 2. Three SARS infections to early onset dementia in this 19 yo. (1) In teens, this didn't happen. World's first case of probable Alzheimer's was recorded in Beijing. (2) Dementia is phase three of HIV or SARS-associated neurocognitive disorder (HAND/SAND).
@Taiwan_CDC 3. Background / pharmaceutical solutions to investigate with urgency.
@Taiwan_CDC 4. I shared this thread today already. Someone care to automate my account? this would save so much time. /s

SARS-CoV-2 Orf10 & N protein.
5. Cue "no one could have seen this coming" 🤡

Well all of us saw it coming. People in power or with public platforms just didn't think a SARS pandemic was something to take seriously.

Guess what, China does.
6. Can those of you who speak Chinese also start bilingual tweets? (same for other languages)

We’re in the twilight zone of socially organized pandemic denial. I think this can help. There are solutions; just need to bring the info to people’s ears if their eyes are wide shut.
7. Bilingual 🇩🇪 (1) SARS-CoV infection in the kidney (Nieren) can activate the complement cascade via C3b deposition, causing severe disease. Good study. (2) Viral persistence up to 500-787 days; reinfection resets the clock. (3) Consider Azvudine (ART) in chronic kidney disease. ImageImageImageImage
8. Ouch.
9. No immunity & SARS-CoV as persistent viral infection? (For up to 500-787 days but made permanent by policy because even the official goal is 1-2 reinfections or year) Mention this to virologists and they’ll deny or not listen.

This is, no nice word here, a global catastrophe.
10. I share so much to help people understand the brutal math. Hundreds of millions were infected globally. 1 in 6, to 1 in 3 develop #Longcovid. To the degree that kidney function deteriorates, people will be unable to initiate antiretrovirals when/IF available in the future. 🤦🏻‍♀️

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More from @_ppmv

Paul Maidowski Profile picture
Mar 18
1. With all but godlike technology in our hands, how badly can we fail a pandemic?

Europeans: yes, oui, Ja!
2. I understand India, Pakistan, Bangladesh’s challenge in a SARS pandemic.

Europe/G7?

Absolutely no excuse. None. ImageImageImageImage
3. Background. XBB.1.16 on the move.
Read 6 tweets
Paul Maidowski Profile picture
Mar 17
1. XBB era

We may conclude the Omicron era (2021-2023). RIP!

See XBB.1.16 XBB.1.9.1 mutations in Orf9b and this thread on 'hypothetical' gene Orf10. Everyone talks about the SARS-CoV spike protein. The nucleocapsid (N) is more important.

Always: N95 mask to protect yourself,🙏
2. Shoutout to indefatigable (and largely volunteer!) variant hunters, doing God's work and states' jobs.

How can you tell the embarrassingly poor state of surveillance and genetic sequencing? The grey area—14%, top right hand—are unassigned variants.

We're sailing blindfolded.
3. As long as evolution and dynamics of SARS-CoV-2 are not FUNDED for the long term—no stop-and-go pandemic cycle of panic and neglect—and well communicated, the public will have no chance to learn fast enough to protect themselves.

Be well everyone, 🙏💁‍♂️ nextstrain.org/ncov/gisaid/gl…
Read 7 tweets
Paul Maidowski Profile picture
Mar 17
The brilliant @mylesbyrne always alerts me to essential, overlooked details. As pandemic-inactivated tango dancer, let me vote "It takes two to tango" as most misleading overused political phrase of the decade.
It doesn't take two.

You always dance with the whole room.

It takes society—profound feelings, often of pain/nostalgia and joy/intensity of connection—and countless human interactions to create music and dance over generations.

In each tanda, you dance in the shadow of giants.
It takes only one to infect half a packed milonga, danced for hours.

Do you see why SARS-CoV's cultural impact will far exceed HIV?

And boy did HIV have an impact. We haven't started facing reality yet in society; the knowledge is still twitter-confined.
Read 6 tweets
Paul Maidowski Profile picture
Mar 17
I'll share bilingual content if time affords, never mind poor language skills. Play to twitter's strengths as polarization intensifies and it gets harder to communicate across academic & cultural boundaries.

Kind souls sometimes translate me+others. Love it; more of this please!
Brilliant PSA. "Se lo conosci lo eviti / Se lo conosci non ti uccide"
"If you know it, you avoid it / If you know it, it doesn't kill you". - The PR/scicomm we need, fast before the average person was infected multiple times.

SARS is the great policy question of our era that no policy scholar - god forbid policymaker - addresses.

Come on everyone
Read 4 tweets
Paul Maidowski Profile picture
Mar 17
1. Life expectancy in a world Living with Covid

People want citations for the claim survival rates 20 years post infection at age 50 may be less than 30%. Look at emerging trends. =>Lawyers and epidemiologists’ job

=>Precautionary principle. Don’t wait to demand policy change
2. I encourage folks to ask smart economists like @lajohnstondr who know trends in China for analysis of these demographic transitions. You can literally see the moment when policymakers got bored with protecting the population in the data!

See old societies like Japan, Germany.
3. @adam_tooze is right. Pay attention to what the pandemic does to rich/old and poor/old countries. You’d expect major societal decline if a country suddenly (subconsciously) decides to throw their old under the bus. Russia already got there; the rest I hope is redeemable.
Read 7 tweets
Paul Maidowski Profile picture
Mar 16
$2k scientific rap €4 billion airline revenue

🤝
Address causes of a SARS pandemic
You see how public health and science are not on equal footing, right?

Some are flying higher than others! Time to ground them in facts again.
Some may think I’m joking in saying there is a tradeoff between climate and society, or my identities as climate scholar/activist and other roles in life.

We may be transparent on Twitter, but wider society is not.

Public health makes this clear. We need to address it clearly.
Read 4 tweets

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