Discover and read the best of Twitter Threads about #Longcovid

Most recents (24)… via @welt

Aan de hand van dit artikel een uitleg over wat mijns inziens #LongCovid is.

Want de verschillende leden van het simplistisch verbond, zoals politici, virologen en microbiologen...
...kraamden natuurlijk de grootst mogelijke onzin uit over wat dit ziektebeeld inhoudt, prettig ongehinderd door enige vorm van kennis of kunde, en zonder ooit iemand gezien of gesproken heeft met deze klachten.
Ik moet zeggen dat ik een glimlach om mijn mond kreeg toen ik dit artikel las. Want natuurlijk was er geen enkel bewijs dat vaccinatie #LongCovid zou voorkomen, en gezien de complexe onderliggende problematiek was dat ook helemaal niet te verwachten.
Read 31 tweets
If you’re still following COVID minimizers— those that tell you that COVID is mild or that try to downplay severity by drawing distinctions without a difference (e.g. hospitalizations "for" vs. "with")— now’s the time to unfollow them. They’ve been lying for clout, here’s proof:
The "breaking" part of this news is the result of a U.S.-based study, but make not mistake about it: there’s been a preponderance of data from peer nations for more than a year. We knew this was going to happen, and that’s why I and dozens of other COVID experts and advocates 2/n
Have were so vocally critical of the "let it rip" strategy that was implemented during the Omicron wave. And why we are still vocally critical of COVID policies that stress "individual risk tolerance" and de-emphasize the need to *prevent* infections.

Read 15 tweets
Long COVID is a well-characterized (if poorly understood) clinical diagnosis around the world. It is not an American phenomenon, no matter how many Twitter randos claim it is
Some countries, like Mexico, even have government-funded #LongCOVID clinics where patients can be evaluated and treated… Image
There’s even a formal W.H.O. case definition for #LongCOVID…
Read 5 tweets
Ok someone said it before me! What about Long Monkeypox. Didn't know if it was in good taste to talk about it so soon. But we learnt the hard way to consider morbidity, not only mortality

Anyway, #monkeypox has known long-term health effects and complications as per @WHO

Reported complications of historical cases of #monkeypox | i.e. before current cases | include secondary infections, bronchpneumonia, sespis, encephalitis, and infection of the cornea, with resulting loss of vision….
Asymptomatic (subclinical | "silent") infection is also noted to occur. #monkeypox as a symptomatic disease can be prolonged in itself, with symptoms and signs reported to last for 2 to 4 weeks according to official guidelines | a bit of deja vu here with the early covid reports!
Read 7 tweets
Big #LongCovid paper out with a lot of new insights (n=78k)!

-76% of LC patients were not hospitalized (!!)
-82% of female patients non-hospitalized vs 68% males
-36-50 year olds were the highest risk age group
-59.8% of patients female; 46.2% male…

1/ Image
-31% had no pre-existing condition

-Heartbeat irregularities were more common in age 13-22 (possibly dysautonomia)

-Myopathies (diseases that affect the muscles that control voluntary movement) were 11.1x more common in #LongCovid compared to the same population pre-COVID!

On average, patients with #LongCovid had higher
HHS-HCC risk scores after COVID-19 than before.

HHS-HCC risk scores identify which patients are likely to consume more healthcare resources & incur more healthcare-related costs in the long run.

Read 8 tweets
Please read our latest review by @jan_choutka et al. on “Unexplained post-acute infection syndromes”.

What a privilege to work with Jan Choutka, who is an #MECFS patient, expert and advocate. Grateful to @mhornig on her expertise/insights 🙏🏼 (1/)…
With millions of #longCOVID patients, it is becoming better known that even a mild infection can lead to longterm debilitating health problems. SARS-CoV-2 joins the long list of other pathogens that cause post-acute infection syndrome (PAIS). (2/) Image
What are some common and distinct symptoms associated with PAIS? Strikingly, there are a number of shared symptoms such as excertion intolerance, fatigue, pain, neurological symptoms..etc. Others are more unique to the pathogen that triggered the disease. (3/) Image
Read 8 tweets
Happy to see a good discussion of #LongCovid in Italy's primetime TV news @tg5med | not perfect, but excellent to see the cardiovascular and cardiopulmonary sequelae openly mentioned, among others | including footage of scanners Image
There has been sometimes a poor depiction of #LongCovid in some Italian venues (with a focus on "fatigue" etc. but not the most severe organ damage, which we know it's not rare even in young people with "mild" disease at onset). The news could have been more explicit about this
But it's still a step forward in respect to less explicit information, provided by some television venues in various occasions (TG5 itself wrongly mentioned #LongCovid lasted only 3 months a few days ago!)
Read 5 tweets
This is a key point => search on online repositories (like PubMed) of #LongCovid papers. Lack of use in some papers of the most-known and most-used term = Long Covid! makes it more difficult to find research which avoid using "Long Covid" itself. Key connections are lost
Co-authors and I addressed the importance of using #LongCovid in a very recent piece out in @LancetRespirMed
Losing information is another issue to highlight and I thank @robert_leaman for mentioning it above 🔝…
Despite these issues, we know there are several thousands of publications on the long-term effects of SARS-CoV-2 infection | #LongCovid
Read 4 tweets
🧵1. It used to be straightforward to determine when we were in a #COVIDinSA wave. Everyone used the ministerial advisory committee’s formula. In 2022, things are a bit more complicated. Some researchers argue this method is no longer all that useful.
2. If we use the MAC formula, the fifth wave started on May 7. But since these numbers alone no longer translate into curfews, lockdowns or liquor bans, @nicd_sa researchers believe a new benchmark may be necessary.
3. The @nicd_sa's @Dr_Groome says #COVID19 case numbers have become less meaningful — using them to calculate a wave, even more so: “Severe outcomes like hospitalisations and deaths are better metrics to use now that we have seen the decoupling of cases and severe outcomes.”
Read 18 tweets
🚨 Molecular mimicry/Aabs driving #LongCovid ?: a🧵
An underrepresented area of LC study which may reveal real answers @NIHRresearch
Tissues, cells & processes affected: clotting, arteries, cardiac, respiratory, brainstem & ANS, mitochondria, thyroid, neurons and many more. 🧵1
'We found SARS-CoV-2 antibodies had reactions with 28 of 55 tissue antigens..incl barrier proteins, gastrointestinal, thyroid and neural tissues, and more...homology with the human tissue antigens mitochondria M2, F-actin and TPO' 🧵2…
'Mimicry of multiple human proteins by SARS-CoV-2...expressed in arteries, lungs, esophagus, pancreas, and macrophages..HLA-A*03 restricted 8-mer peptides are shared broadly..with primary expr of the mimicked human proteins in neurons and immune cells'🧵3…
Read 12 tweets
And so it begins...

I'm in a rural town of 3,000 just 20 minutes from the 8th largest city in the US and this is the ONLY Walmart in town. No HEB (our local chain in San Antonio) and no Costco.

THIS IS IT! ImageImageImageImage
Perhaps @PierreKory @P_McCulloughMD @richardursomd @DrJBhattacharya @BretWeinstein and a dozen other "#HeroDoctors" can stay stuck on their #PsychoticEpisodes and talk about how #IVM is safe and effective and would solve this problem if only it were #OTC like it is now in TN and Image
soon to be in NH - as if 2+ years too late that even matters anymore.

We're on the 5th vaccine, #LongCovid is a thing. These same doctors are opening #PrivateClinics to further profit off of our deaths as they have their entire careers while being #SilentlyObedient and none of ImageImageImageImage
Read 10 tweets
Whoa—@bankofengland just warned that deep concern of surging #LongCovid is taking workers out of the workforce. The spike ⬆️ in workers age 16-64 who do not work because of long term illness during the #COVID pandemic is alarming, and fast increasing. Mass infection depravity.🧵 Image
2) “Since Q4-19, the number of people aged 16-64 years that are outside the workforce and do not want a job has risen by 525,000 (1.3% of the 16-64 age population). This **largely reflects increases in long-term sickness** (roughly 320,000 people) and retirement (90,000), Image
3) “The share of the 16-64 who are outside the workforce and do not want a job because of long-term sickness is a record high, with an especially sharp rise among women—much of this rise in inactivity due to long-term sickness reflects side effects of the pandemic, eg Long Covid”
Read 7 tweets
🧵 on repeat infections, negative lateral flow & #PCR tests, and the use of #COVID19 antibody tests. An n=1 experience #OmicronVariant #LongCovid #MedTwitter #TeamGP #psychtwitter #LongCovidKids #COVIDisAirborne #CovidIsNotOver 1/n
I had acute #COViD19 in Nov 2020, PCR +ve. Developed #LongCovid a month after. Had one dose #Pfizer Feb ‘21 which gave me new symptoms. Out of interest I had my anti-spike antibodies done May ‘21- they were above the upper limit the assay could measure 2/n
With the passage of time my antibodies dwindled. I had them rechecked in Dec 2021- both nucleocapsid & spike antibodies were below the protective limit. Therefore I had no protective antibodies. 3/n
Read 17 tweets
Thanks for sharing my thread on covid | #LongCovid!
This was a thread specifically focusing on some of the most cutting-edge techniques used to study the disease. For example, groundbreaking imaging, or the study of gene expression ~ dysregulation

There is much more research going on on both acute and #LongCovid. A lot of this research is based on less powerful, but more accessible techniques, like the SPECT scan to study lung damage, or various kinds of cardiac tests, to assess heart function.
Studies have now started to cover the 2-year period, which have elapsed since when covid appeared. A follow-up of the early patients from China recently published in @LancetRespirMed, has revealed a significant disease burden two years from infection in that group
Read 5 tweets
Was invited back to @StanfordMed to present to their Infectious Disease faculty last week. Few comments stuck out:

“80% of our #LongCovid patients have his exact same story: young, previous healthy, mild case, & now severely debilitated” Image
“It’s a very different experience to hear about #LongCovid from a patient like yourself than it is to read about it in studies, it’s critical more physicians & researchers learn about this disease from the patient perspective” Image
Then lots of good questions around what doctors can do to improve approach to care ~ & lot of palpable anxiety/tension around the tsunami of patients they’re seeing & expecting. “#LongCovid clinics will not be a sustainable model of care.. need better treatment”
Read 5 tweets
An early release from CDC reports on the higher stability of Omicron on surfaces (steel, paper) in comparison to ancestral strain. Any infection or reinfection has the potential to trigger #LongCovid. Please continue to wear masks and wash your hands 😷🙌… Image
"Compared with the ancestral SARS-CoV-2, the Omicron BA.1 variant was more stable on all surfaces we studied (Table). On day 4 postinoculation, we recovered no infectious ancestral SARS-CoV-2 from stainless steel, polypropylene sheet, or 2 of 3 glass samples.
"We did not recover infectious virus from glass on day 7. In contrast, infectious Omicron variant was still recoverable from all treated surfaces on day 7 postincubation. The stability of the Omicron variant was also higher than ancestral SARS-CoV-2 on porous surfaces, …
Read 4 tweets
Many with #longCovid are finding it difficult to describe what they are feeling. Those of us in the #MECFS and #ChronicLymeDisease #EDS community have had longer to think about and put these experiences into words…
Post-viral illness wreaks havoc on multiple systems within your body which of course are interconnected. The way I describe it is that you are losing your body’s life force — this is different from your soul. And it’s not just energy. It’s your actual life’s force.
In the beginning when you first get sick, you can still feel the healthy parts of you versus the sick parts — kind of like layers of an onion.

But eventually the sick parts seep into the healthy parts and you can no longer distinguish between the two.
Read 18 tweets
So this version of normal ie “living with the virus” *SEEMS* to not be working out so well, with another surge, new onset rapid liver failure in children, further increasing rates of stroke, etc. Great news, we actually can still do a lot to clean indoor air & protect each other! CDC COVID transmission map ...
2/ We really need to push our leaders to invest in improving ventilation and filtration in buildings. This has been shown to improve cognitive function & protects people not just from #SARS2 & #COVID19 but all other germs in the air! Start with schools! These are systemic issues! Opening windows, using port...
- Authorize for children under 5. #ImmunizeUnder5s

- Boost ages 5-11 just authorized!

- Stay up to date on vaccines/boosters

System wise:
- Invest in mucosal vaccines.
- Invest in global vaccine distribution or virus will continue to spread & mutate
Read 9 tweets
New piece out in STAT with @gaby_arguedas. We argue that the omission of #LongCovid from public health messaging is harmful to the public in multiple, overlapping ways…
@gaby_arguedas Public health messaging throughout the pandemic has focused almost entirely on hospitalizations and deaths, w/ COVID infection not resulting in hospitalization characterized as “mild”.
The recent guidance change on masking from @CDCgov was couched almost entirely in terms of impacts on healthcare and prevalence of severe disease
Read 10 tweets
We've known covid and #LongCovid have a significant endothelial, thrombotic and cardiovascular component since early 2020. As per Long Covid, this was initially brought to wide attention by the patient community

We have been discussing this online since early 2020, among the many living with #LongCovid already. This work has often been done via chats, tweets etc., namely beyond the official "channels" of medicine. It remains poorly acknowledged and poorly recognized
Yet, papers by patient teams were drawing attention to the cardiovascular and thrombotic potential of #LongCovid already in 2020 "mild manifestations in the prodromal stage may progress to severe disease and sequelae including cardiovascular and thrombotic .." (Perego et al 2020)
Read 13 tweets
The profile of a person with #longcovid just appeared on my Instagram feed. I clicked on their profile. They are now using a wheelchair.

On their profile are some story highlights from a year ago. I clicked on some of them...
The first two show this person at a @NuffieldHealth 'rehab' class, clearly pushing themselves way too much.

The next two stories show this person in bed listing all their symptoms—'the reality after my class'.

'Got to keep trying', they write....
A post from last year indicates that this person did indeed try graded exercise therapy and got significantly worse. Replying to someone warning of the dangers of GET, they reply: "I learnt this the hard way, sadly".
Read 6 tweets
I wanted to share a story of a patient I saw this week. Very fit man aged 52, previous marathon runner, suspected mild #COVID19 March 2020. Extensively investigated by cardiology in 2020 for symptoms of chest pain, dizziness and struggling to exercise 1/
Cardiac MR showed some fibrosis suggestive of previous myocarditis, but all other Ix were normal. By November 2021 he was back to running 15km, but very slow improvement. Dec 2021 had booster followed by COVID re-infection over a couple of weeks (again mild symptoms) 2/
After this he developed similar symptoms to 2020, dizziness on walking up stairs, chest pain (anginal sounding). We did his spirometry and gas transfer - completely normal. On the 1 minute sit-to-stand he desaturated to 92%, HR increased from 49 to 110 and he became quite SOB 3/
Read 13 tweets
The Bank of England openly addresses the impact of #LongCovid on workforce and labour dynamics
I've been writing this since 2020 but I do it again: Long Covid is a disaster in the making. It'll affect public health and economy for decades to generations…
The range of covid damage to the body is vast and not uncommon, especially in those who aren't vaccinated. New variants are increasingly able to evade prior immunity including from the vaccine. Policy makers still fail to appreciate the longest term impact of covid
Viruses are already implicated in the development of cancer, neurodegenerative diseases, multiple sclerosis, autoimmune diseases and cardiovascular diseases, to name just a few. We are infecting and reinfecting half of the globe with a virus which has already killed 15 millions
Read 4 tweets
#chronicillness Twitter to doctor advocates
-you’re only speaking out because you’re sick yourself
-now you know what it’s like (implication- all of us neglected & psychologised patients before. NOT true- some of us just did our best within a system stacked against us)
-you need to mention ‘x’ disease as well. (We’re learning as fast as we can. Remember we are sick too. Some of us are bed-bound lying in darkened rooms. You know how much energy it takes to speak up)
-don’t dabble in areas you know nothing about. (In my case #Palestine. Being a chronic illness advocate doesn’t make me a one-trick pony. I’ve visited the West Bank & witnessed firsthand the horrors of #IsraeliApartheid. So I will speak up- I’m not here for anyone’s comfort
Read 5 tweets

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