OK, so @WHO have, in the space of a few weeks, confirmed that SARS2 remains a #PHEIC, then compared it to seasonal influenza...
Anyone else confused/astonished/outraged?
No, we are not in the same position as in 2020, and thank goodness that’s the case. But, it does not mean the
job is done. Consider if COVID emerged now as a new disease with associated harms, would we act? Of course we would.
Ironically, the fatigue many feel is due to mismanagement of the pandemic and swinging like pendulums from extreme measures to the total absence of restrictions.
This does not occur in many South East Asian countries, who brilliantly applied test, trace, support and isolate both prior to, and following the availability of vaccines.
I do not understand how a virus that continues to cause mass hospitalisation, longer term and latent health
issues, and of course, long COVID across all the age groups on such a scale, can be classified as anything other than an emergency. A PHEIC is a scenario that requires international cooperation and coordination of responses across multiple countries to limit the spread of disease
It seems we may have reached a point of international disinterest, rather than the disease becoming a “non-emergency”. This disinterest seems primarily centred in richer, highly vaccinated countries with good healthcare systems, who can also afford therapeutics. The inequity in
all of these areas remains to be addressed.
Whether or not governments choose to acknowledge, test for, survey, vaccinate against, or behave in a manner commensurate with responsible public health, should not – in my opinion – change the reality of this disease. The notion of
“living with” COVID is a privileged choice, and ultimately it’s discriminatory against those least able to cope, either from a health or a socioeconomic perspective, and this applies on all levels from individuals to countries. Consider how many “key worker” groups now represent
those most likely to report suffering from long COVID.😞

There has been a worryingly successful drive to focus upon individual risk, which is all well and good provided we have safety nets in the shape of public health policies. However, these seem to have been deliberately
abandoned in the UK and other countries. The example of crossing the road is always a good one – something we do every day that is unlikely to end in tragedy, we are also unlikely to know someone killed in this way, and yet we’re aware on a national scale that RTAs are a major
cause of harm that we legislate against…the government is trusted to do this, and yet the ongoing pandemic is referred to by MPs and the mainstream media in the past tense.
Population scale risk matters. 2022 saw five successive waves of COVID in the UK, killing more than 30K
people and hospitalising many times more than this. Over 2 million people report suffering from long COVID, which is almost certainly an underestimate, and our under-resourced NHS simply cannot cope with this on top of catching up with the backlog that’s been growing since 2010
See pinned tweet by @lee_georgina, simply brilliant, but brutal as well...

So, some suggest that SARS-CoV2 should be treated as influenza. Some have calculated that the individual risk in our population of dying of COVID is similar to that of influenza AND pneumonia (important
difference as SARS is much more likely to be the underlying cause). However, risks need to be scaled by prevalence to calculate the clinical burden of disease, and the area under the curves for COVID still dwarfs that of SEASONAL influenza and other viruses for this very reason,
and this is before we start to factor in widescale morbidity that is actively reducing the UK workforce.
Importantly, SARS2 is NOT endemic, which means predictable, not benign. The waves we see are a direct result of ongoing rapid viral evolution that escapes antibody responses.
Yes, behaviour exacerbates this, but we are nowhere near a seasonal pattern of behaviour. This said, we could also do so much more to limit the impact of flu and other diseases as well, but for some reason the lessons learned from the past few years are being forgotten. We also
cannot rule out that the pi VoC may surface at any point – it wasn’t that long ago that many considered delta to be the evolutionary peak for this virus.
Perhaps most worrying is the continued isolation and discrimination against the millions of clinically vulnerable people,
especially those unable to make effective vaccine responses. The UK squandered the opportunity to embrace prophylactic therapeutics for this group, and the number of early onset antiviral treatments is now dwindling in the face of waning research funding.The UK squandered the
opportunity to embrace prophylactic therapeutics for this group, and the number of early onset antiviral treatments is now dwindling in the face of waning research funding. The reality is that whilst only “most” people live with COVID, far too many people either don’t, still, or
or end up having to live in spite of it. Ignorance may be bliss, but sadly this is not the case for all.

A critical way forward, to ensure that as many of us CAN live safely in spite of this virus, is to create infection resilient environments, to stop the pressure on
presenteeism and drive for 100% school attendance, and to support and advocate for vaccination programmes instead of dithering. The fact that SARS-CoV2 is not yet part of pre-school vaccinations is just astonishing, and yet other countries have taken this sensible step forwards.
We must move forwards, not pretend it’s 2019 again.

We CAN make infection resilient environments, improve safety in schools, tailor COVID vaccines and ensure long term programmes rather than infecting kids, support isolation and sick pay, fund the #NHS properly, install NPIs if
environmental factors can't be improved, research better therapeutics and vaccines, research long COVID and adverse reactions, maintain surveillance and sequencing, speed up medical approvals, increase awareness of risk, ensure healthcare settings are safe...
We choose not to 😒
We revert to pre-pandemic norms, they are safe for many, but they neglect a significant few...
We could manage all respiratory viruses better, and others. Flu vax push, approve zoster, expand COVID repertoire...it's doable, but funding is lacking...pandemic preparedness forgotten
again.
Folks worry rightly about costs...well, of course, but tech is getting better and cheaper, plus don't tell me we don't have £££££s, Brexit bailouts, VIP, submarines, aircraft carriers, NHS outsourcing, etc etc...why is it necessary to write about the same 💩 over and over?

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More from @SGriffin_Lab

Mar 15
Today is #LongCovidAwarenessDay
This is SO important, because it's likely that a great many people are NOT aware of it...
Unseen disabilities and chronic health conditions are something that millions of Brits face and deal with on a daily basis.
This isn't helped by black and
white judgemental nonsense from folks that don't understand the nature of such things.
Remember the whole nonsense around disability benefit fraud in the 2010s, people with blue badges being attacked when they didn't have a wheelchair in their car boot?
Sometimes people can
outwardly seem to function reasonably normally in public (ideally with reasonable adjustments in place), but to carry on like that costs them dear when they get home...
Then, there are the people that remain unseen, forgotten, behind closed doors and relying on others for their
Read 12 tweets
Mar 13
So, exasperated with the total lack of mitigations against a pandemic, I settled in to write one of my verbose threads...then realised I'd done it already and the situation hasn't really changed much...aside from getting worse!

We STILL have next to no

investment into the future of clean air, no public awareness of viral prevalence (SARS-CoV2, and its' mates), little ability to act altruistically because testing has evaporated and supported isolation remains a figment of most people's imagination...there's nothing safeguarding
our workplaces, schools, universities, public transport, shops or other public spaces, no masks, mis/dis-information is rife and anti-vax narratives now echo round the house of commons thanks to certain feckless mockeries of public representatives...

Most people think the COVID
Read 22 tweets
Mar 8
So, COVID vax entering preschool programme is frowned upon by some...after all "kids are all infected anyway, and they don't get sick"...a 🧵

This excellent paper is often cited to support that protection from infection is equivalent to vaccines...

nejm.org/doi/full/10.10…
Sure, protection from infection and hospitalisation appear better in the infected cohort...

BUT, what's sometimes missed is the actual numbers reflecting how we get to these pretty graphs...

193K infections, 309 hospitalised, 7 died
273k vaccinees, 15 hospitalised, 0 died
Other important points:

The vaccinated cohort included either one or two shots...we know from adults that three is best, so efficacy could theoretically be improved.

Vaccinating pre-infected kids improves protection, the authors recommend boosters for both vaxd & infected kids
Read 16 tweets
Feb 26
So, according to certain cardiologists, MPs, disgraced former Pfizer employees and Harvard profs, non practicing pathologists, signers of declarations, presenters on nationalistic news channels, members of groups with monosyllabic acronyms and coloured pebbles, Z list celebs, a
worryingly large cohort in MSM, proponents of "evidence-based" pigeon chess, some in PH focused upon individual rather than population scale risk, and a plethora of anonymous social media accounts, the vast majority of the population is suddenly at risk from all manner of cardio-
vascular, or other terrible ways we might meet our ends, and whoever is left will be unable to have kids, or be put on some kind of trial for supposedly being paid and/or influenced by former software developers or "the WEF", all in a kind of end of WWII reenactment party...
Read 4 tweets
Feb 17
@georged00rs @AnnLHowarth @NICEComms The vaccines were trialled with efficacy end points concerning the prevention of hospitalisation, severe disease and death.
Transmission is a separate issue, there are very few vaccines that provide sterilising immunity, and this is always for invariant viruses...not like SARS2.
@georged00rs @AnnLHowarth @NICEComms However, there was clear efficacy vs transmission during the Wuhan/Alpha stages, which matched the vaccines.
Delta (also beta and gamma before) showed us the first signs of escape from antibodies, but like most biological concepts this is a spectrum.
Omicron and its offspring
@georged00rs @AnnLHowarth @NICEComms now represents a considerable genetic distance from the Wuhan strain. But, protection vs severe disease remains, at least for mRNA vax...less so for killed vax like in China.
Our antibody responses are therefore mismatched, are complicated due to prior infection/vax history, and
Read 12 tweets
Feb 15
This is getting beyond a joke...
JC is now accusing HCW following guidelines by @NICEComms of inflating #COVID deaths via iatrogenic means...yes, killing patients with medicines.
I'm not a clinician, but I do know that e.g. diamorphine and medazolam aren't given lightly.
JC is
also of the opinion that many of those who succumbed would have simply got better if left without intervention...
He goes to the trouble of explaining "evidence based medicine" whilst showing purely associative, speculative and offensive "correlations" between spikes in drug use
and the first two waves...
I wonder, what in the PRE-VACCINE era might have caused a load of palliative drugs to be needed during pandemic waves? Not that JC advocates vax anymore either...🙄

He gets the years wrong, wrongly asserts that COVID pneumonitis/ARDS was treatable with
Read 9 tweets

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