Eduardo Schenberg, PhD Profile picture
Mar 22 โ€ข 12 tweets โ€ข 7 min read
This equinox the @IPCC_CH released the updated edition of our best "manual for spaceship earth" ๐Ÿ˜‰, nicely summarized by Prof. @KHayhoe here:

Should we build connections between our existential #climatecrisis and psychedelics?
๐Ÿงต๐Ÿ‘‡ Image
In a nutshell:
"a batata ๐Ÿฅ” ta assando ๐Ÿ”ฅ"
(the potato is roasting), as people say in Brazil ๐Ÿ‡ง๐Ÿ‡ท when facing complicated problems Image
But the GOOD NEWS ๐Ÿคž is that YES we have many #AvailableSolutions ๐Ÿ’ซ

And as I highlighted in green in this image, indigenous lands and knowledge are fundamental for implementing some key solutions. Image
According to the @IPCC_CH summary (p31): #Cooperation, and inclusive decision making, with #IndigenousPeoples and local communities, as well as recognition of inherent rights of Indigenous Peoples, is integral to successful adaptation and #mitigation across forests and ecosystems
What's more, it's up to #us responsible adults in #THISDECADE, to take action which will impact livelihood for centuries. We are the first, and last, who can #act.

The task? Cut greenhouse gas emissions by 60% by 2035, preserve and restore ecosystems and biodiversity. Image
So one of the biggest challenges is to protect indigenous territories and the #abundance of biodiversity they care for Image
And what do #psychedelic drugs have to do with this?

EVERYTHING.

This biotechnology field, foreseen to soon reach billions of dollars, is predicated on sacred indigenous gatekeeping of practices persecuted and prohibited for centuries. ImageImage
The huge opportunity to be built?

Directing ๐Ÿ’ฐ resources from the psychedelic biotech industry's patented compounds, based on indigenous knowledge, to an international, cooperative, indigenous-led land protection and restoration fund.

pubs.acs.org/doi/10.1021/acโ€ฆ
How?!? BIG Q, needs a big answer to be collectively built!

But three widely adhered international treaties are a place to start: ILO-169, cbd.int and the Nagoya Protocol. Image
Failing to do so can forever mark our current generations for lack of responsibility and maturity regarding the extreme threat to mental and physical health posed by the climate emergency, for which no ammount of pills and therapy will ever be enough. ImageImage
Time to act is NOW โฒ๏ธ, and developing new treatments is necessary, but not sufficient.

There is HUGE potential for #prevention as well, through psychedelic resource allocation for indigenous rights and climate change mitigation!
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More from @ee_schenberg

Feb 16
This is likely the single most important paper in psychedelic science ๐Ÿ’ซ since "the LSD lid" (2017) and the "dmt-sigma 1" (2009) publications

What connects them is literally mind-blowing ๐Ÿคฏ
Absolutely congrats to @DEOlsonLab and all collaborators ๐Ÿ‘๐Ÿ‘๐Ÿ‘๐Ÿ‘๐Ÿ‘ science.org/doi/10.1126/scโ€ฆ
Here is the 2017 LSD "lid" paper by @zenbrainest et al, also superb cell.com/cell/fulltext/โ€ฆ
Read 4 tweets
Jan 14, 2022
This week #psychedelics, almost completely ignored by western science and medicine in the last quarter of the 20th century, made it to the top of ๐Ÿ‡บ๐Ÿ‡ธ healthcare, the @NIH:

4k folks ๐ŸŒ 21 time zones
+10h of talks
Panelists from
๐Ÿ‡บ๐Ÿ‡ธ 12
๐Ÿ‡จ๐Ÿ‡ฆ 1
๐Ÿ‡ฎ๐Ÿ‡ฑ 1
๐Ÿ‡ฉ๐Ÿ‡ฐ 1
๐Ÿ‡ฌ๐Ÿ‡ง 1
๐Ÿ‡ณ๐Ÿ‡ฟ 1
๐Ÿ‡จ๐Ÿ‡ญ 1

๐Ÿงต summary ๐Ÿ‘‡
Agenda comprised 3 main themes:
Basic and translational research ๐Ÿ€๐Ÿ”ฌ๐Ÿ‘ฉโ€๐Ÿ”ฌ๐Ÿ‘จโ€๐Ÿ”ฌ๐Ÿงฎ๐Ÿ’ป
Clinical trials ๐Ÿ‘ฉโ€โš•๏ธ๐Ÿง‘โ€โš•๏ธ๐Ÿ‘จโ€โš•๏ธ๐Ÿคฎ๐Ÿ’Š๐Ÿค’๐Ÿ’‰
Optimising future trial designs ๐Ÿ’พ๐Ÿ’ฝ๐Ÿ’ฟ๐Ÿ“€
Here are my remarks from 20y experience:
This is a good landmark to claim psychedelic science finally achieved maturity
Basic research is evolving rapidly and public funding ๐Ÿ’ฐis what is needed to transform the field
Clinical trials suggest transdiagnostic safety and efficacy
Read 5 tweets
Jan 13, 2022
Third and last session of #psychedelics @NIH ๐Ÿ‡บ๐Ÿ‡ฒ workshop starting now, looking at how to optimize clinical trials design and how to get these treatments approved ๐Ÿงต
Starting with Ido @hartogsohn ๐Ÿ‡ฎ๐Ÿ‡ฑ on psychedelic set and setting theory
Important Q โ“

Do we have an (excessively) costly and complicated drug regulation apparatus?
Read 19 tweets
Jan 13, 2022
Today is the second day of psychedelics @NIH ๐Ÿ‡บ๐Ÿ‡ฒ with a critical issue to be tackled:

What is a #controlled study with psychedelics?

How to do it?

Why is it important?
Starting now with Michael Bogenschutz from @nyuniversity discussing what was left in the background yesterday: subjective effects
Mixed correlation results between MEQ subjective ratings and therapeutic outcomes for alcohol abuse ๐Ÿค”
Read 36 tweets
Jan 12, 2022
Psychedelics making it today to the top of USA ๐Ÿ‡บ๐Ÿ‡ฒ health institutions: @NIH
Joshua Gordon started emphasizing NIH's #mechanistic funding focus
4k attendees in 21 time zones ๐ŸŒ๐ŸŒŽ๐ŸŒ
Read 30 tweets
Oct 8, 2021
researchgate.net/publication/35โ€ฆ

Overcoming #EpistemicInjustices in the biomedical study of #ayahuasca: Towards #ethical and sustainable #regulation. New paper for โ€œCultural context and ethical issues in the therapeutic use of psychedelicsโ€ special issue of Transcultural Psychiatry ๐Ÿงต1/
We (me and non-tweeter ๐Ÿ‡ง๐Ÿ‡ท PhD lawyer Konstantin Gerber) reviewed 4 decades of biomedical research about the sacred and ancient vine of the Amazon, documenting how biomedicine systematically commits a specific kind of injustice: against indigenous people as givers of knowledge. 2/
The powerful concept of epistemic injustice was introduced 15 years ago by Miranda Fricker (University of Oxford) and greatly helped us frame and analyse some past and current trends in ayahuasca research, which is also important to psychedelic science in general. 3/ Image
Read 17 tweets

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