Thread by @JohnEbbenMDPhD

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 2/6 #TumorBoardTuesday
Thurs Case🎀

#mCRC & #EGFR tx:
✅Anti-EGFR useful in RAS/RAF WT; debate re: timing vs anti-VEGF
✅Pt centered discussion including SEs 🗝️
✅Emerging data: EGFR re-tx, using ctDNA to guide

📚@shafiarahman_ @RischZack’s thread:
threadreaderapp.com/thread/1638330…

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 3/6 #TumorBoardTuesday
🎥 TBT in a vid- Part 1:

@shafiarahman_ 's approach: pt eligible for EGFR-directed tx in #metastatic #CRC
🔹RAS/RAF WT- more important than side
🔹Bev or pan 1L? Trend toward pan, but is 🗝️actually that pt gets anti-EGFR in tx, 🚫necessarily 1L?

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 4/6 #TumorBoardTuesday
🎥 TBT in a vid- Part 2:

@shafiarahman_ gives us a preview of what might be coming in #EGFR directed tx in #mCRC
🔹Re-challenge based on ctDNA clearance of resistant clones; pts w resistance to EGFRi benefit later as the tumor evolves again
🔹New combos!

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 5/6 #TumorBoardTuesday
Thurs Case🎀
📷 TBT in an image

Patient centered discussions are essential to choosing a 1L strategy in RAS/RAF WT (or in any case!). Need to consider:
🔹Potential benefit to EGFR mAb- upfront vs later
🔹Different tox (acneiform rash)
💸Increased cost

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC @SamuelKareffMD @jacobadashek @FogacciJoao @BenWestphalen @marklewismd @ColonCancerDoc @KarunaMDPhD @GIcancerDoc @KimmieNgMD 6/6 #TumorBoardTuesday
Thurs Case🎀

🤔Will ctDNA be tool for rational EGFR tx re-treatment?

➡️Join us on 03/28/23 when @tompowles1 @drfrankiejs present a case of 1L tx choosing between pembro regimen & nivo + cabo regimen!
UK leads staying up to join us. 8pm ET/12 am UK time!

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC @SamuelKareffMD @jacobadashek @FogacciJoao @BenWestphalen @marklewismd @ColonCancerDoc @KarunaMDPhD @GIcancerDoc @KimmieNgMD @tompowles1 @drfrankiejs Remember #TumorBoardTuesday continues to offer CME credit for FREE! Don’t forget to answer the polls👇🏽
Then click this link to quickly request your credit!
CME eval🔗: integrityce.com/TBTeval23
ALL CME 🔗: integrityce.com/TBT2023

https://twitter.com/rischzack/status/1638349517245366273?s=46&t=rqlcgeJ3YmI3uFExDJQb_A

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