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@nick_krontiris
Mar 26 • 6 tweets • 2 min read • Twitter logo Read on Twitter
The findings of this one suggest that reversal of alterations of the GH/IGF-1 axis after surgically-induced weight loss is unlikely related to improved leptin secretion and/or whole-body insulin sensitivity, but is rather associated with improvements in adipose tissue function. Image
- The reversal of alterations of the GH/IGF-1 axis after bariatric surgery related to improvements in adipose tissue function, but not whole-body or hepatic insulin sensitivity:
- The study found lower GH concentrations in humans with obesity than in lean humans in the setting of similar IGF-1 concentrations, indicating a preserved IGF-1 feedback mechanism.
Multiple regression analysis adjusted for age and sex revealed no association between the long-term improvement in GH concentrations and changes in body weight, peripheral or hepatic insulin sensitivity, glycemia or leptin levels...
...but a negative association with the reduction in insulinemia, lipid availability, adipose tissue insulin resistance and low-grade inflammation, underlining an important role of adipose tissue also for the regulation of GH/IGF-1 axis in metabolic diseases.
Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function (open access)

doi.org/10.1038/s41366…

#MetabolicSyndrome #Obesity #InsulinResistance

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More from @nick_krontiris

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Mar 29
This one not only brings forth evidence that challenges the current crossover concept, it also suggests that low-carb diets may also reverse features of pre-diabetes and future metabolic disease risk. Image
- The article (mostly) used data from these two papers:


- The data from these studies sheds doubt to the popular concept that human athletes are unable to extract any meaningful degree of energy from fat oxidation during exercise at intensities >85%VO2max.
Read 12 tweets
Nick Krontiris Profile picture
Mar 29
In this one, high intakes of seafood, and particularly small fish rich in n-3 fatty acids, was associated with a lower risk of 10-year fatal and non-fatal cardiovascular disease risk in Greek adults with a mean age of 45.2 years. ImageImage
- Less than one-10th of the study participants consumed >1 serving of small fish rich in n-3 fatty acids per week.
- Participants who consumed >2 servings per week of seafood had at least 27% decreased risk of developing CVD and 74% lower 10-year risk of dying due to CVD.
Read 6 tweets
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Mar 28
Interestingly, using NMR spectroscopy, this one suggests that newly manifest type 2 diabetes-associated dyslipoproteinemia does not significantly change the total concentrations of the lipoproteins produced in the liver, but selectively their subclass distributions.
- In the present study, German long time blood donors that were assumed to be healthy according to the rules applying for blood donors were examined.
Impaired fasting glucose, impaired glucose tolerance or manifest type 2 diabetes were not known for this group before they were included in this study.
Read 13 tweets
Nick Krontiris Profile picture
Mar 28
In this one, 3 isocaloric meals with different macronutrient compositions showed different postprandial metabolic profiles, with postprandial exercise altered substrate oxidation and preventing hyperglycemia induced by an high-carbohydrate meal. Image
- The study aimed to assess the collective effects of 3 isocaloric meals: higher in carbohydrate (74.2% energy), fat (64.6% energy), or protein (39.5% energy) on energy expenditure and clinical and metabolomic biomarkers in men with normal weight or overweight/obesity.
- The 3 isocaloric diets varying in macronutrients showed distinctive postprandial metabolic profiles, while exercise altered substrate oxidation and inhibited the hyperglycemia induced by the higher-carbohydrate meal.
Read 5 tweets
Nick Krontiris Profile picture
Mar 28
This systematic overview suggests that the literature overall confirms the existence of the physical activity paradox in healthcare workers.
- The physical activity paradox states that even though leisure-time (particularly moderate-to-vigorous) physical activity promotes health, more relative time spent on (particularly moderate-to-vigorous) physical activity during work seems to impair health.
- This systematic overview found that, in healthcare workers, occupational physical activity is primarily conducted at light to moderate-intensity and leisure-time physical activity at light- to high intensity.
Read 11 tweets
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Mar 28
This one found no differences in the postprandial rise in muscle protein synthesis rates following ingestion of 30g protein provided either as cheese or as milk protein at rest or during recovery from exercise in healthy, young males. Image
- The study compared the impact of ingesting 30g protein provided in the form of cheese or milk protein concentrate on postprandial muscle protein synthesis rates in vivo in 20 healthy, young males.
- An increase in circulating amino acid concentrations following the ingestion of 30g protein provided either as cheese or milk protein was observed.
Read 15 tweets

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