@OpenAI#ChatGPT4 "hallucinations" remind me of a now-amusing event from way back in Grade 3 when I was 7, involving the last time I knowingly confabulated. I was assigned to write a report about airplanes.✈️ One thing I already knew about airplanes: they were expensive! (1/12)
According to my parents, the high cost of airplane tickets was why our family always drove the tedious 800+ miles from our NYC suburban home to see relatives in Michigan at Christmas🎄If 4 airplane *tickets* were expensive, I reasoned an *entire airplane* must be hugely costly.
I found lots of good airplane info, which went into that report. But couldn't find ANYTHING about cost. I looked everywhere a kid could look in the 1970s: encyclopedias, school books, library books. Nothing. Desperate, I made up a plausible number 😲 and added it to the report.
Something about that number, which seemed so plausible to me - perhaps because it started with 199 trillion dollars, and had lots of trailing 8s & 7s - invited skepticism from my teacher. She thought it was invented! (Shrewd at spotting data falsification, like @MicrobiomDigest )
When the reports were handed back after grading, I had no grade, only a circle around the $199 trillion number and the dreaded red "See me after class" mark. So I stayed behind to be interrogated during recess.
To my embarrassment 40 years later, I recall that initially I (half-heartedly) claimed I'd encountered this $199 trillion cost number in an older encyclopedia, - one that the school didn't have - and suggested that might be why it was so surprising to her. She remained skeptical.
She said my report was otherwise well written but because of lingering questions about the validity of that one data point, she couldn't hang my report on the big bulletin board in front of the classroom where the best work went. To that point my work had *always* gotten hung up.
This was devastating, like the pediatric equivalent of a scientific/medical journal rejection.😢 I was in tears, and offered to retract this one controversial data point if I could just have the report hung up on the big blue board. But it was too late; the damage had been done.
She gave me a lecture on honesty which I never forgot. She even mentioned George Washington and the cherry tree. In hindsight, countering dishonesty with a myth about a Founding Father was problematic, but we'll give her the benefit of the doubt that her intentions were good.
She then handed the report back to me and said I could instead write something *truthful* about trains to make up for it. This was an act of mercy, because she knew I really liked trains. So I wrote that report with passion and zeal - and it got hung up on the big blue board.
So I asked #ChatGPT who I am (I know, I know😉) and here is the response. Paragraph 1: Bogus. For the record, I've never worked in Medical Affairs & was at @DanaFarber / @harvardmed 2009-2020. (It also thinks my terrific solid tumor compatriot Alice Shaw works at another company)
Where does AI get this stuff?! 🙃 This week's @NEJM has articles about use of AI in health care, which is so promising, and
I’ve never posted a @tiktok_us link before, but this is a rare opportunity to observe one of the most poorly understood disorders in #hematology: Gardner-Diamond syndrome. This young woman's skin lesions first appear about 40 seconds in./1 #MedTwittertiktok.com/@nancy.xoxx/vi…
The syndrome was described by Drs. Frank Gardner (1919-2013) and Louis K. Diamond (1902-1999) in Boston in 1955, in @BloodJournal. They reported 4 cases, all women, who had a peculiar form of bruising on face or extremities but had no other bleeding & normal coagulation tests./2
The key finding in Gardner-Diamond syndrome: unexplained painful bruises, most commonly on extremities or face, often during times of stress. The pathophysiology is unclear, as described below. Many patients have been dismissed by physicians as having a fictitious disorder./3
Among the many things I am #thankful for: recent progress in hematologic malignancies. When I started my career - not that long ago! - standard therapy for myeloma was melphalan & prednisone or VMP, chlorambucil for CLL, CHOP (without R) for NHL, epoetin & transfusions for MDS./1
CML was treated with Hydrea, busulfan, or interferon & Ara-C,and the big debate was transplant timing. Most patients didn't have an allo transplant donor & the age cutoff was 50-55. Karyotyping was inconsistently done even in AML/MDS; FISH was new; single gene testing was rare./2
No one knew about JAK2 mutations, let alone envisioning specific JAK2 inhibitors. There were elderly patients with polycythemia we treated with radiophosphorous. Many clinical trials were small IITs. The most "exciting" progress was in hairy cell leukemia: pentostatin & 2-CDA./3
A medical textbook nostalgia thread! I dug up my @UChicagoMed transcript & recalled what books we used for each class. Buying books online was rare back then, so most came from the University bookstore at 58th & S Ellis, or the claustrophobic but amazing @SeminaryCoop on 57th./1
Year 1, Term 1 (Autumn): Netter’s Atlas of Human Anatomy (1989 edition), Wheater’s Functional Histology (1987), Moore’s Developing Human: Clinically Oriented Embryology (1988), Stryer’s Biochemistry (1990). (If you had another biochem text from undergrad, you could use that.)/2
One weird fact about U of C medical school: back then med student skeletal anatomy was taught by paleontologists, including @NatGeo Explorer-in-Residence Paul Sereno (here's his Facebook image). So we learned not just about human anatomy, but how humans differ from dinosaurs.🦖🦕
K-562. It was the first human cell line I ever tried to grow in culture, during training @MayoClinic. It was also the first immortalized myeloid leukemia #cellline, published @BloodJournal way back in 1975. What does the K stand for? #HematologyTweetstory 37 is on cell lines./1
K-562s were derived from a the pleural effusion of a 53 year-old woman with #CML in blast crisis, so they have Ph+/BCR-ABL. She'd been treated with busulfan for 3 years & pipobroman for a year (limited & crummy Rx options back then), and died 9 days after cell collection./2
The K in K-562 is for “Knoxville”, where the University of Tennessee & precursors have resided since 1794. The 562? Maybe a vial name. Only Argentinian-born Drs. Carmen & Bismarck Lozzio @UTKnoxville knew; they isolated the cells & published in 1975: sciencedirect.com/science/articl… /3
Stumbled across this today when looking for a different reference and did a double take - another David Steensma, and a Dr Papaemmanuil who is not @PapaemmanuilLab, publishing on #ICUS which we have both published on - neither are especially common surnames 😮
I have to find this guy and publish with him and cause EndNote confusion forever after /2
As an undergraduate @Calvin_Uni I published a quantum physics paper with Bob Steen, and we were desperate to get Steve Steenwyk in the department to author with us so it could be the Steen-Steensma-Steenwyk paper, but it didn’t work out /3
It is often said that Marie Skłodowska-Curie died of "aplastic anemia." Try Googling it; you'll find many hits. But I am not so sure. She died on July 4th, 1934, at a sanatorium called Sancellemoz, in Passy, Haute-Savoie, France, after a long illness. #aplasticanemia#MDS /1
The 1937 biography by her younger daughter Ève describes her final illness, including a consultation at Sancellemoz (postcard) by a "Professor Roch." That would have been Maurice Roch, Regent of @UNIGEnews & father of famous Alpinist André Roch who planned Aspen, Colorado./3
Here is how the daughter's biography describes that consultation. Mention is made of fevers and blood tests - rapidly falling WBC & RBC counts - and that X-rays were done. (The last thing she needed: more radiation!). Diagnosis: "Pernicious anaemia in its extreme form." /3