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Viki Male Profile picture
@VikiLovesFACS
Mar 28 • 4 tweets • 2 min read Twitter logo Read on Twitter
#Menstrual changes in those who received a #CovidVaccine (3,635), caught #COVID (1,802), both (1,354) or neither (5,788)...

🦠 Infected more likely to report shorter cycles, missed periods, heavier periods, spotting

💉Vaccinated only: no difference

1/
cell.com/iscience/pdf/S…
Previous studies have found menstrual changes associated with vaccination, but these have been small and short-lived, so it's perhaps not surprising that a retrospective survey design can't detect them. 2/

This is the first study I know of that attempts to directly compare menstrual effects of COVID vaccination and infection, finding that infection is likely to be more of a concern. 3/3
With congratulations to first author @AlexAlvergne!

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More from @VikiLovesFACS

Viki Male Profile picture
Mar 24
🇮🇱 48,868 babies followed for first 120 days of life. Does being born after a #CovidVaccine booster in #pregnancy protect against hospitalisation for COVID?

👉🏻 Yes! With 53% effectiveness compared to two doses only.

1/
nature.com/articles/s4159… Cumulative COVID hospitalisations in babies whose mothers we
Other important findings…

👉🏻 Protection is greater when the booster dose is given later in pregnancy

👉🏻 Protection wanes as babies get older, with no significant protection after 90 days, in this study.

2/ Graph showing that babies whose mothers were vaccinated late
A lot of parents and paediatricians have been in touch with me recently querying the policy of offering a booster as early as possible. Wouldn’t it be better to delay and maximise protection for babies? The authors have something to say here… 3/ Screenshot from paper: “Moreover, as the circulation of SA
Read 4 tweets
Viki Male Profile picture
Mar 15
🇺🇸 30,311 babies followed from birth to 6 months, of whom 10,893 were born following #CovidVaccination in #pregnancy.

👉🏻 Protection against COVID infection in the delta period was 56%

👉🏻 In the omicron period, 13%

1/
nature.com/articles/s4146…
This study quite nicely shows how protection declines over time as maternal antibodies wane. For delta, protection against infection is:

84% in the first two months

62% in the first four months

56% in the first six months

2/2
Important additional note 👇🏻
Read 5 tweets
Viki Male Profile picture
Mar 4
@toadmeister Hi Toby! Our most up to date information on births and newly registered pregnancies in the NHS (to October 2022) shows no decline in either... 1/

@toadmeister It’s worth noting that the HES dataset, which you’re using there, isn’t yet finalised (though it will be shortly). So some births in the most recent months are not yet included in the dataset… but that doesn’t mean they didn’t happen. 2/

@toadmeister And here's more from an epidemiologist working on these datasets... 3/

Read 4 tweets
Viki Male Profile picture
Feb 24
@DrAseemMalhotra Hi Aseem! It would be very surprising if this one study had really found what the author claims, given the overwhelming body of evidence now showing no increased risk of any pregnancy problems following COVID vaccination... 1/

@DrAseemMalhotra But the study he is talking about has been preprinted, so we can take a look right now... 2/

preprints.org/manuscript/202…
@DrAseemMalhotra As the author said, he aims to compare the number of reports in VAERS for flu vaccines, from 1998 onwards, to those for COVID vaccines, from 2021 onwards.

This assumes that the rates of reporting over those periods are comparable, as the authors acknowledge in the preprint. 3/
Read 10 tweets
Viki Male Profile picture
Oct 29, 2022
@DarrellSpins That’s a good question. For increased cycle length, we can make two observations:

1. People on combined hormonal contraception are less likely to experience this

1/
frontiersin.org/articles/10.33…

medrxiv.org/content/10.110…
@DarrellSpins 2. People vaccinated early in their cycle are more likely to notice an effect.

2/
medrxiv.org/content/10.110…
@DarrellSpins Both these observations suggest a temporary effect of the innate (first phase) immune response on the hormones that drive the cycle. 3/
Read 7 tweets
Viki Male Profile picture
Oct 4, 2022
Just out! A new meta-analysis of 81,349 ppl receiving #CovidVaccine during #pregnancy compared to 255,346 unvaccinated. Vaccination...

👉🏻 Protects against infection

👉🏻 Lowers chance of stillbirth by 27%

👉🏻 Lowers chance of babies needing NICU by 12%

jamanetwork.com/journals/jamap…
I’ve been asked for some additional context around whether the 27% reduction in stillbirth reported by this paper is likely to be an overestimate…

🧵
This is particularly worth considering because a similar meta-analysis found that the rate of stillbirth was reduced by 15% among those vaccinated in pregnancy - rather less than the 27% reported here… 2/

nature.com/articles/s4146…
Read 11 tweets

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