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#LongCovid
1/3 Viral persistence and spike shedding may decrease the amount of ACE2 in some cell types and tissues. 2012 research showed that knock-out of the ACE2 gene in mice resulted in greatly increased inflammation in the gut following intestinal damage.
1/3 Viral persistence and spike shedding may decrease the amount of ACE2 in some cell types and tissues. 2012 research showed that knock-out of the ACE2 gene in mice resulted in greatly increased inflammation in the gut following intestinal damage.
2/3
POTENTIALLY, this is a factor for those with Long Covid.
"genetic inactivation of ... ACE2 results in severe colitis following intestinal injury. "
ncbi.nlm.nih.gov/pmc/articles/P…
POTENTIALLY, this is a factor for those with Long Covid.
"genetic inactivation of ... ACE2 results in severe colitis following intestinal injury. "
ncbi.nlm.nih.gov/pmc/articles/P…
Lower "ACE2 links amino acid malnutrition (especially Typtophan) to microbial ecology and intestinal inflammation" as ACE2 assists in absorption of some amino acids by the gut epithelium.
"serum levels of the neutral amino acids valine (Val), threonine (Thr) and tyrosine (Tyr), and the essential amino acid tryptophan (Trp) were markedly reduced in Ace2−/y mice" Rich sources of Tryptophan are chicken and soy.
"Pathological induction of ADAM17 dur-
ing SARS-CoV-2 infection through direct viral mechanisms or the ensuing inflammatory response triggers aberrant cleavage of ACE2 into the circulation, thereby reducing its tissue expression and blocking its local regulatory effects"
ing SARS-CoV-2 infection through direct viral mechanisms or the ensuing inflammatory response triggers aberrant cleavage of ACE2 into the circulation, thereby reducing its tissue expression and blocking its local regulatory effects"
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