Bunk the Biologist Profile picture
Mar 30 5 tweets 2 min read Twitter logo Read on Twitter
1/5 A new #Covid_19 autopsy study finds viral persistence in the cartilage rings surrounding the bronchi in the lungs. These patients were testing negative by PCR for Covid-19 but had persistent lung inflammation - eventually resulting in their death. doi.org/10.1002/path.6…
2/5 POTENTIALLY, viral persistence in the bronchial cartilage could relate to the chest/rib pains experienced by many with Long Covid #pwLC and Post-Vax symptoms #vaccineinjuries This is one of the top 30 symptoms from my informal patient surveys. recoverfromlongcovid.com/vaccine-injure…
3/5 "antibodies against both spike and nucleocapsid revealed the frequent (70%) infection of bronchial cartilage chondrocytes and para-bronchialgland epithelial cells. In a few patients (19%), we also detected positivity in vascular pericytes and endothelial cells"
4/5 "Together, these findings indicate that SARS-CoV-2 infection can persist significantly longer than suggested by standard PCR-negative tests, with specific infection of specific cell types in the lung." i.e. > 9 months
5/5 "Whether these persistently infected cells also play a pathogenic role in long COVID remains to be addressed."

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Bunk the Biologist

Bunk the Biologist Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @BiologistBunk

Mar 28
#LongCovid
1/3 Viral persistence and spike shedding may decrease the amount of ACE2 in some cell types and tissues. 2012 research showed that knock-out of the ACE2 gene in mice resulted in greatly increased inflammation in the gut following intestinal damage.
2/3
POTENTIALLY, this is a factor for those with Long Covid.
"genetic inactivation of ... ACE2 results in severe colitis following intestinal injury. "

ncbi.nlm.nih.gov/pmc/articles/P…
Lower "ACE2 links amino acid malnutrition (especially Typtophan) to microbial ecology and intestinal inflammation" as ACE2 assists in absorption of some amino acids by the gut epithelium.
Read 6 tweets
Oct 12, 2022
Two promising biomarkers for long covid in the blood. Two factors, ANG-1 and P-SEL involved in blood vessel inflammation - at about 90 days post infection. The researchers still need to follow long-haulers over time to see how the levels change. molmed.biomedcentral.com/articles/10.11…
"two vascular biomarkers were identified that distinguished Long-COVID patients from acutely ill COVID-19 inpatients and healthy control subjects (accuracy of 96%). Our data suggest that both of the two, ANG-1 and P-SEL, have potential as disease biomarkers"
NOT THE SAME AS ME/CFS: "Our data suggests that Long-COVID is biochemically distinct from ME/CFS as all 14 vascular biomarkers increased in plasma from Long-COVID patients ... In contrast, levels of P-SEL, MMP-1, ICAM-1, VEGF-A and VEGF-D either do not change with ME/CFS"
Read 6 tweets
Oct 4, 2022
A logical reason for Tinnitus and Dizziness - viral infection of the Inner Ear. nature.com/articles/s4385…
"Here, we describe patients with COVID-19 and new-onset of hearing loss, tinnitus and/or dizziness."
"We show that human inner ear cells have the ability to allow SARS-CoV-2 entry. We further show that SARS-CoV-2 can infect specific human inner ear cell types. Our findings suggest that inner ear infection may underlie COVID-19-associated problems with hearing and balance."
Read 5 tweets
Jul 19, 2022
A little known but potentially important clinical trial using a mixed probiotic for mild Covid-19 for 30 days. 3 of the 4 strains were Lactobacillus plantarum strains. ab21probiotic.com
The majority of #longhaulers, experience a flare-up of their symptoms after taking just one capsule of L plantarum. Sometimes for 3 or 4 or 5 days. This may be stimulating Type I interferon production via one of our cell's Pathogen Recognition Receptors: cGAS
This may be a way to bypass the viral suppression of Interferon production in infected cells. The production of Interferon stimulates hundreds of genes and makes our cells (and neighboring cells) a very unfriendly place for pathogens - including SARS-CoV-2.
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(