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Nick Krontiris Profile picture
@nick_krontiris
Apr 20 • 9 tweets • 2 min read Twitter logo Read on Twitter
The findings of this one may suggest that both individuals with very low and very high levels of circulating IGF-1 may be at an increased risk of cancer mortality, cardiovascular mortality and all-cause mortality. Image
- Circulating levels IGF-1 exhibited a U-shaped relationship with all-cause, cancer and cardiovascular mortality.
- For cardiovascular mortality, the U-shaped relationship was stronger in men and in participants who were older than 55 years at baseline.
- Stratified analyses revealed that the risk of mortality among participants with low IGF-1 levels were more pronounced among participants with indications of liver diseases and dysfunction.
- The risk of mortality among participants with low IGF-1 relationship was attenuated but persisted after excluding participants with elevated liver enzymes and other liver conditions...
...suggesting that ill liver health may explain some but not all risk observed in participants with low IGF-1 levels.
- Higher circulating levels of IGF-1 were associated with increased risk of breast and prostate cancer incidence, whereas individuals in the lowest quintile of IGF-1 levels were at increased risk of incident lung cancer.
- Individuals in the lowest quintile of IGF-1 experienced increased hazards of mortality from digestive diseases, especially liver cirrhosis.
IGF-1 and risk of morbidity and mortality from cancer, cardiovascular diseases, and all-causes in EPIC – Heidelberg (open access)

doi.org/10.1210/clinem…

#MetabolicSyndrome #Obesity #cancer

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More from @nick_krontiris

Nick Krontiris Profile picture
Apr 20
The findings of this one suggest that intermittent exogenous ketosis may be a potent nutritional strategy to facilitate recovery from strenuous endurance exercise, thereby stimulating beneficial muscular adaptations. Image
- The primary aim of this study was to characterize the mechanistic effect of ketone ester ingestion on muscular angiogenesis.
The study investigated whether ketone ester ingestion could increase pro-angiogenic factors and thereby stimulate muscular angiogenesis during a three-week endurance training-overload period involving 10 training sessions/week in healthy, recreationally active, male volunteers.
Read 18 tweets
Nick Krontiris Profile picture
Apr 20
In this one, a higher adherence to the EAT‐Lancet Healthy Reference Diet was associated with lower risk of cardiovascular disease and coronary heart disease but was not associated with lower risk of total stroke, ischemic stroke, and hemorrhagic stroke.
- Higher adherence to the Healthy Reference Diet as proposed by the EAT‐Lancet Commission was associated with a 14% lower risk of CVD and a 12% lower risk of CHD.
- No significant association was found for total stroke, ischemic stroke, and hemorrhagic stroke, although the number of cases was relatively small for stroke subtypes and the magnitude of associations was comparable to those of CVD and CHD.
Read 6 tweets
Nick Krontiris Profile picture
Apr 20
Interestingly, in this one, caffeine and catechins ingested alongside polymerized polyphenols from oolong tea lowered postprandial glucose, insulin and C-peptide responses following a high-fat meal challenge. Image
- The objective of the study was to assess whether polymerized polyphenols from oolong tea ingested alone or with caffeine and catechins lowers postprandial lipemia.
- 50 healthy adults completed 4 oral lipid tolerance tests in a placebo-controlled randomized, crossover design.
Read 10 tweets
Nick Krontiris Profile picture
Apr 19
The findings of this one suggest that blood flow restriction accelerates fatigue but does not increase the signaling events and muscle growth responses during low-load resistance exercise. Image
- The purpose of this study was to examine if reduced blood flow during exercise alters the acute signaling and training-induced muscle hypertrophy responses when exercise is performed to task failure.
- In the present study, the acute signaling responses 2 hours after low load-resistance exercise with and without blood flow restriction performed to task failure were investigated.
Read 10 tweets
Nick Krontiris Profile picture
Apr 19
This one suggests that low circulating adiponectin is a key damaging element for β-cells.
- Diluted plasma from human donors with obesity acutely impaired β-cell integrity and insulin secretion relative to plasma from lean subjects.
- Similar results were observed with diluted sera from obese rats fed ad libitum, when compared to sera from lean, calorically restricted, animals.
Read 11 tweets
Nick Krontiris Profile picture
Apr 19
This one in macaques suggests that a maternal Western-style diet may alter long-term immune cell developmental programming in hematopoietic stem and progenitor cells in utero, predisposing the offspring to inflammatory disease across the lifespan. Image
- Maternal Western-style diet exposure was associated with in utero developmental programming of hematopoietic stem and progenitor cells to a pro-inflammatory phenotype.
- Maternal Western-style diet exposure was associated with persistent pro-inflammatory phenotypes at the transcriptional, metabolic, and functional levels in bone marrow-derived macrophages and in hematopoietic stem and progenitor cells in juvenile offspring...
Read 5 tweets

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