Thread by @slfwlr

So excited to announce our preprint describing tau in extracellular vesicles from Alzheimer's disease brain tissue! A thread... ➡️ @Duff_Lab @bwfalcon

doi.org/10.1101/2023.0…

#neuroscience #brain #science #extracellularvesicles #CryoEM #teamtomo

We used quantitative mass spectrometry to profile 8 density fractions of human brain EVs: check out github to explore the data: github.com/duff-lab-team/…

Extra special thanks to @darraghpobrien and @EmirTurkes1!!

Tau in EVs is pathological and can seed prion-like tau propagation in the brain🧠

Check out these filaments inside EVs 😊 Filament identification made possible by groundbreaking subtomogram averaging of tau filaments inside protected membrane compartments, and is the result of the very hard work & genius of @BehrTiana 🙌🙌🙌

Cryo-ET of intact vesicles shows tau like you've never seen it before - so many interacting proteins - what are they up to, and what can they tell us about tau?

Tau in EVs is different from cellular tau! Let's work towards targeting these unique tau species to stop the spread of pathology and improve patient outcomes 🍊

Thanks to our co-authors, funding partners, and host institutions for all the support!
@UKDRI @MRC_LMB @EmirTurkes1 @paulavmc @marthafoiani @Ger_Crowley13 @SumiBez @Hellen_Eva @darraghpobrien @NDMOxford @BethGeary4 @findpal @PasqualeDAcunzo