Discover and read the best of Twitter Threads about #brain

Most recents (24)

Right now, we're going after the pathology of the disease–plaques & tangles-but I think we need to start going after the biology and, as a result, the pharmacology that addresses the altered biology with aging that occurs in Alzheimer's-@a_hfillit @TheADDF
biospace.com/article/ctad-2…
“Lecanemab slows #cognitivedecline. But this is only a start to stopping Alzheimer’s in its tracks. We have a lot of ground to cover to get from the 27% slowing #lecanemab offers to our goal of slowing cognitive decline by 100%"-@a_hfillit on #CTAD22 data
alzdiscovery.org/news-room/anno…
“The mixed data shows that while anti-amyloids are a promising starting point, we will need a combination of drugs aimed at different targets informed by the biology of aging to effectively treat this disease”
-@a_hfillit, M.D., co-founder and CSO @TheADDF
fiercebiotech.com/biotech/roche-…
Read 4 tweets
"Retirement" from work as a risk factor for #Dementia: experience of 5 recent patients

1. I saw 5 new cases of dementia last month, which apparently started within 6 to 18 months after retirement from work. All were cognitively normal until retirement.

#MedTwitter #Alzheimer
2. Memory impairment was the most prominent symptom. Over a period of time, other symptoms such as impaired calculation, speech impairment, losing sense of direction, poor judgement and inability to do daily activities without assistance, also started. Symptoms were progressive.
3. A diagnosis of Alzheimer's disease was made on the basis of detailed neuro-psychological assessment, brain scans and other appropriate investigations.
Two patients had comorbid #depression. Three patients had #sleep disorders- two had #insomnia and one had excessive sleep.
Read 10 tweets
Ready for a quick #science lesson? 🧵

In your body, energy needs to be produced in the right amount, in the right place, at the right time, and it goes through an unimaginably fast recycling process that involves #mitochondria.
The #mitochondria that aren’t moving appear to stay in places where things are always happening—either near factories where proteins are made (ribosomes) or synapses where there is a lot of activity, which is a very important fact relevant to how the #brain functions.
Researchers looking at #braincells under #microscopes have known for decades how to identify where the synapses are—they look for the mitochondria.
Read 7 tweets
"Liquid and Solid #Brains: Mapping the #Cognition Space"

Today's SFI Seminar by Ext Prof @ricard_sole, streaming now — follow this 🧵 for highlights:

Image
"Why #brains? Brains are very costly...it seems like they are not a very good idea to bring complex cognition to a #biosphere that just needs simple replicators."

"I also want to explore the problem of #consciousness, which is around all the time..."

@ricard_sole Image
Two different views of #evolution:

- Stephen Jay Gould and an emphasis on #contingency

- Simon Conway Morris/Pere Albach and an emphasis on #constraints and #convergence

--> "Replay the tape with different results vs. 'the logic of monsters' & 'life's solution'" Image
Read 21 tweets
Question that hit me on October 26th, 2017: is there a temperature window that stops 🛑 tumor growth, and the brain 🧠 can tolerate? If so, this could prevent tumor recurrence and buy the patient time to try therapies until we reach a cure.
2/12
🔑findings:
1. Tumor cells stop growing at room temperature (20-25°C). Remember, body temperature is 37°C.
Even 18 hours of cooling per day can be enough! 🕒 This point will be useful for a device in the future.
3/12
Read 12 tweets
Clinical Case for Junior Doctors and residents
1. 20-yr old was brought with history of non-progressive difficulty in walking and poor cognitive functions since childhood. Motor and language milestones were delayed. Perinatal history was unavailable.
#NeuroTwitter #MedTwitter
2. Patient's gait is shown. What is the gait abnormality?
3. MRI of brain is shown. What are the abnormalities? Image
Read 5 tweets
Head‑to‑toe #POCUS skills for intensivists in the general and neuro #intensivecareunit population: consensus and expert recommendations of the European Society of Intensive Care Medicine.
🔗pubmed.ncbi.nlm.nih.gov/34787687/
#MedEd #IMPOCUS
Summary of the recommendations
#POCUS #Brain
Thorax #POCUS
Read 6 tweets
1/They say form follows function! Brain #MRI anatomy is best understood in terms of both form & function

A #tweetorial on how to remember important functional #brain #anatomy

#meded #medtwitter #neurosurgery #neurology #neurorad #FOAMed #FOAMrad #radiology #medstudent #radres
2/Let’s start at the top. At the vertex is the superior frontal gyrus. This is easy to remember, bc it’s at the top—and being at the top is superior. It’s like the superior king at the top of the vertex.
3/It is also easy to recognize on imaging. It looks like a big thumb pointing straight up out of the brain. I always look for that thumbs up when I am looking for the superior frontal gyrus (SFG)
Read 12 tweets
Chapter 14

of *Psychology of Apocalypse: Ecopsychology, Activism, & the Prenatal Roots of Humanicide*

by Michael Adzema, is titled,

“Prenatal Suffocation Become Greed & Class War, PME 2:”

READ THREAD or CLICK a link for free BOOK

THREAD sillymickel.blogspot.com/2022/02/psycho… #womb

PA 14/1
Chapter 14 is subtitled:

“Prenatal Matrix of Human Evil 2...

“Gasping, Suffocation, Drowning, Being “Cut Off” Become Greed, Oppression, Conformity...

““They’re Sucking the Very ‘Life Blood’ Out of Us!””

READ BOOK> wp.me/p1n96g-3FZ #psychology #prenatal #anthro

PA 14/2
[Quotes/highlights:] “The timelessness of prenatal experience at this point—when not getting enough air—feels horrific, an unending nightmare. This part contributes to human ideas of places of forever, endless suffering, for example, hell.” []

drive.google.com/file/d/1gewWZG…

PA 14/3
Read 134 tweets
@MichelTdS and I wrote a #review on the last decade of #brain #connectivity #research for a special issue in @ScienceMagazine : 'circuits create networks by stringing together many brain regions to orchestrate brain symphony conducted by finely attuned connections.' A 🧵
First things first, the #cover shows that the corpus callosum has different axonal calibres, as shown in a cross-section of the axons. Warmer colours (red-yellow) indicate thicker axons. These finely attuned connections allow for the perfect orchestration of the brain symphony.
There is a growing consensus: functions are an emerging property of the interaction between brain areas. Function-specific brain activity involves the integrative effort of several brain regions. White matter connections support this integration by interconnecting brain regions
Read 10 tweets
Are there any changes in #brain #structure during the first year following #trauma #exposure? Is there a difference between individuals who develop #chronic #PTSD and those who #recover? A quick thread about our work published today in @molpsychiatry📜🧠🧵
nature.com/articles/s4138…
Reduced #hippocampus and #amygdala volumes have been repeatedly documented in #PTSD patients. But do they reflect a #pretrauma vulnerability trait or #postexposure stress-induced atrophy?
To answer this question, we examined the association between #longitudinal #volumetric #changes of the hippocampus and the amygdala, as well as their #key #subregions, and #PTSD #symptom #trajectories during the first #14months following #trauma exposure. Image
Read 10 tweets
Lazarus sign is a reflexive movement seen after or near brain death (BD) w/ arms raising & dropping to chest. It’s essential to know all the reflexes seen with BD to provide realistic expectations to families. 🧵 #neuroscience #brain #CriticalCare
50% of brain dead patients demonstrate spontaneous, reflexive movements. The most common movements are finger jerks, undulating toe flexion sign, triple flexion response, pronation-extension reflex, and facial myokymia.
Do not confuse these reflexive movements with recovery, improved prognosis, or volitional movements, and educate families about their lack of clinical significance. @DL_Hollywood
Read 3 tweets
50 yo female with progressive eye redness and loss of visual acuity. She has a h/o hypertension. Thoughts? #MedEd
#MedTwitter #health #healthcare #FOAMed #ClinicalPearl #clinicaltips #neuroscience #neurotwitter
#sciencetwitter #brain #medstudenttwitter #medical Image
Neuro intact other than vision.
What is reason for redness, specifically?
Read 4 tweets
✨✨We are thrilled to share 2 new papers published this week in:
#BiologicalPsychiatry: Genetic heterogeneity shapes brain connectivity in psychiatry
dx.doi.org/10.1016/j.biop…

#Brain: Brain connectivity mirrors genetic pleiotropy in psychiatric conditions academic.oup.com/brain/advance-…
1/7 #Polygenicity (=multiple genetic variants associated with one condition) and #pleiotropy (=one genetic variant influencing more than one trait) are key properties of the genomic architecture of #psychiatric conditions and represent major challenges in identifying mechanisms.
2/7 We processed 9 rs-fMRI datasets including 32,726 individuals, to examine the connectome-wide effects of 15 copy number variants, 7 polygenic scores (common variants), and 4 idiopathic psychiatric conditions (Autism, Schizophrenia, ADHD, Bipolar disorder).
Read 8 tweets
📌 Major changes in the Boston Criteria v.2.0 for Cerebral Amyloid Angiopathy diagnosis 👇

(🧵 1/4)

#neurotwitter #FOAMrad #radres #NeuroTwitter #NeuroRad #Neurology #Neurosurgery #RadEd #stroke #dementia #brain #Alzheimers
📌 Summary Panel on "Probable CAA"👇🏿

🩸🧠Most commonly used CAA diagnostic category

#FOAMrad #NeuroTwitter #NeuroRad #Neurology #Neurosurgery #RadEd #stroke #DementiaJoe
🧠🎯Key MRI markers of Cerebral Amyloid Angiopathy

- Easy to look for in clinical MRI scans
- Typical examples and MRI signal 👇

@gboulouis @marco_pasi85 @lsveikata @Cuneatos @svinsociety @MayoClinicNeuro @MayoRadiology

Read 5 tweets
Major update for small cell #lung cancer! #LCSM

With @juliensage + @FoundationATCG, our paper now on @bioRxiv:

►Genomic analysis of *3,600* pts with SCLC; largest SCLC study to date!

►Multiple interesting findings discussed in this 🧵
biorxiv.org/content/10.110…
🧵2
This study is unique in many ways:

> The #SCLC cohort studied came mostly from community sites --> representing a more typical “real-world” cohort of SCLC.
> The genomic data are tied to clinical data + outcomes.

#LCSM
🧵3
To the best of our knowledge, our study analyzes the largest number of SCLC tumors from African ancestry to date:
> n=256 AFR cases
> 7.1% of the entire cohort
#Diversity in clinical studies is critical!!
See tweet 🧵9 for more details.
Read 15 tweets
Dear #hr in #niin #ksom #usc, I know you are busy,but could you spend 8 mins on my emails pls? I sent 6 emails from April to June, and called you every day this week, but I didn’t get any reply. #neuroscience EAD will be expired at 07/10😩@USC @KeckMedUSC @KECKSchool_USC @USCNIIN ImageImageImageImage
Thanks,friends in #twitter in #niin,#ksom, #usc, in #neuroscience, #neuroimaging, #neuroradiology. I really appreciate your support. I got the email this afternoon. It’s my fault. Even leave, leave with pride, grace, and gratitude, no regret. The 4 yrs will be the best memory in Image
my life, although it is also the hardest 4 yrs. Hope other colleagues could take my lessons, and prepare everything earlier in the future.
Read 31 tweets
1/
The @OHBM #BrainArt exhibit is live! Come stop by Hall 4 to visit this year's special theme exhibit “The Connected Brain”.

Check out our featured artists in the thread below.
👇🏻👇🏻👇🏻
2/
Anne Sikora’s work is an interactive installation à l’odeur representing five #emotions : love, anxiety, happiness, sadness and aggression. All guests/attendees are invited to smell the sweat of these emotions and may guess which is which.
3/
@cbuyukberber’s “Hyperconnection” takes the initial generative form that has been created as a mural based on @vborghesani’s studies on comparing the states of the #brain while we process language & turns it into an animated meditative deep dive into the organic #networks.
Read 14 tweets
BRAIN UPGRADING.
"To upgrade oneself, the object to work on is our brain. The process may include unlearning to learn and learning to unlearn. Whichever is the case the #brain can never be over exploited.

In every ideal #society, learning is required for universal relevance and/
acceptance. Anyone who cease to learn cease to grow and signed in for demotion or #stagnancy.

Engaged in a discussion with one of my sons this morning, I made him realized there are ways we learn without alerting our #teacher in quote, so learning may be cheap atimes./

@SIAF_NG
However, active learning comes by deep interactions between the master and the learner. It's therefore extremely tedious and most time not #achievable to be a master of what is not deeply learnt or handed over to one by a sacrificial #learning act.

@UnboxTherapy @MentallyAwareNG
Read 9 tweets
Excited to share our new paper out at @NatImmunol today! We discovered the limiting factor for #brain #Tregs is #IL2, and developed a new #genetherapy to treat #traumaticbraininjury and other #neuroinflammatory pathologies. 1/12

nature.com/articles/s4159…
The work started more than 10 years ago, after my brother Russell died following a #traumaticbraininjury. The more I read into it, the more treatable #neuroinflammation seems. Obviously there is a #brain delivery problem, but stopping #inflammation is basic #immunology! 2/12 Image
We had a great post-doc, @EmanuelaPasciu1, drive a project showing #Tcells in mouse and human brain, with key functions. Among these T cells were a small population of anti-inflammatory #Tregs, again in mouse and human. 3/12
cell.com/cell/fulltext/…
Read 12 tweets
Excited to share our paper “Somatic genomic changes in single Alzheimer’s disease neurons”, published today in @nature!
nature.com/articles/s4158…
[1/19]
@Nature This was a wonderful collaboration with August Huang @tuihuaorjinhua, mentored by @ChrisAWalsh1 @EAliceLee2 and @_MikeLodato, with contributions from many others across multiple institutions. @BostonChildrens @BrighamWomens @HHMInews @harvardmed @UMassChan @broadinstitute
[2/19]
@Nature @tuihuaorjinhua @ChrisAWalsh1 @EAliceLee2 @_MikeLodato @BostonChildrens @BrighamWomens @HHMINEWS @harvardmed @UMassChan @broadinstitute Somatic mutations in the genome of cells are a major part of how we think about cancer, but recent studies found that somatic mutations also occur in “normal” cells, and build up in neurons and in other cells as we age.
[3/19]
Read 19 tweets
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
Read 93 tweets
While #science thought us that we can even cut and paste #genes with #CRISPR technology…even with that we only influence 3% to 5% of #chronicillness. The rest depends on #how you #live your #life!!! So how do we #SelfRegulate our #body?
1. Good #sleep is more important than most think! What happens during sleep? The fluctuation of consciousness…that we call the waking state. But in many wisdom traditions of the world, the waking state is merely a lucid dream that consciousness is having…
Read 41 tweets
Does #gut #microbiota interact with #microglia in the #aging #brain? Are microglia metabolically affected (#mitochondria)? Does #diet take part? any #translational data?
Our paper made it last week in @NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159… Image
1. Microglia from aged and young-adult #male & #female mice, under SPF or #germ_free conditions were profiled by bulk #RNAseq. We identified a gene-set, which depended on the housing condition regardless of #age & regulate central processes in microglia. "Microglial GF signature" Image
2. Utilizing #WGCNA, we found major differences between microglia of SPF and GF mice in the aged groups. But do we see any functional difference on a cellular level? Image
Read 13 tweets

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