Discover and read the best of Twitter Threads about #brain

Most recents (24)

I’ve seen some people tweet that #coronaviruses might not be capable of persistence. But over the past decades, coronavirus RNA/protein has been identified in a range of human samples after acute illness, and sometimes connected to chronic disease
2/ For example, this team found coronavirus RNA and/or antigen in both plaque + non-plaque areas of brainstem, cortex, and spinal cord samples obtained from patients with MS: ncbi.nlm.nih.gov/pmc/articles/P… Image
3/ This team identified a range of DNA/RNA viruses in tissue samples obtained from healthy humans at autopsy. Coronavirus 229-E was found in brain, thyroid, heart, lung, stomach, adrenal gland, skin and blood samples: bmcbiol.biomedcentral.com/articles/10.11… Image
Read 11 tweets
Our new study on genetic determinants of dietary intake is out in @NatureHumBehav

Paper: nature.com/articles/s4156…

Press release: massgeneral.org/news/press-rel…

Summary stats will be available soon at @AMP_CMDKP

A short summary below:
Diet is an extremely complex exposure. In addition to measurement error, noise, correlation with other traits, reverse causation, or variation across life course, diet is based on substitutions. That is, a higher intake of A necessarily implies lower intakes from B and C.
To accommodate the substitution nature of diet, we used multivariate GWAS to factor the correlation between dietary carbohydrate, fat, and protein in 282,271 participants of European ancestry from @uk_biobank and CHARGE Consortium @chargetiger
Read 10 tweets
The receptors involved in SARS-CoV-2 infection are co-expressed in the cells of the NVU, especially in astrocytes and microglial cells. These receptors are functionally active as exposure of endothelial cells to the SARS CoV-2 S1 protein subunit ..
#HIV
#ACE2
#brain
altered the expression pattern of tight junction proteins, such as claudin-5 and ZO-1. Additionally, HIV-1 infection upregulated ACE2 and TMPRSS2 expression in brain astrocytes and microglia cells.
#astrocytes
#microglia
#brain
SC2 in BBB mechanism. Image
Read 10 tweets
1) 🇬🇧 The 8 steps of UK #LongCovid prevalence research in a nutshell - By an upset parent.
1. Child suffers disabling symptoms for over 12 months
2. GP says it is health #anxiety and standard blood tests show nothing wrong, so there can not be anything wrong.
3. #Parent has been
2) using Zoe app, but gives up logging symptoms after x months as they can't see the point anymore. No one believes they are sick anyway
4. Child has disabling symptoms for over 12 months
5. GP says children don't get #longcovid as the @govuk has told them this
3) for the last 18 months. Parent and child both dismissed as "anxious". #Child never sees a #paediatrician as GP dismisses them & paediatricians, therefore, don't see many kids with #longcovid.
Read 7 tweets
How do brains rewire throughout life?

Our paper out in @Nature today outlines several principles of brain circuit development that we found by mapping the complete wiring of eight brains.

nature.com/articles/s4158…

#neuroscience #connectomics #brain #neurons #celegans #science
PDF available here for anyone interested in the full story: rdcu.be/cr1BK
Read 3 tweets
1/🧵Wake-Up to how #SLEEP flushes waste from your brain 🧠 @JAMA_current
 
I may get more done when I 💤 less, but I lose the long-game! #Evolution dictated that we gain an advantage by spending 1/3rd of our lives asleep.

I’ll tell you WHY? bit.ly/3qPgzAA

#MedTwitter
2/ Why do we sleep? Brain rest? To process bad decisions or incomplete conversations? Maybe. But the coolest reason is removal of #amyloid & #tau proteins that cause #dementia. Our #glymphatic system does this most efficiently during deep sleep.
 
3/ Have I mentioned that I’m fascinated by the glymphatic system? It’s the lymph system for our #brain & serves as the “garbage” removal program to keep our #neurons healthy. Wanna know more?
 
Read 12 tweets
Thread about #painless #birth

Did you have painless contractions?
Tell me your #birthstory
#momlife #pregnancy #OXYTOCIN

threadreaderapp.com/thread/1411279…
I think this topic might trigger some in particular, bc of the #religious belief that #WomenMustSuffer

#christian cultural training:
In their origin story,
the women was the reason #EveAndAdam were damned. Because of Eve’s failure,
they believe
#childbirth must hurt.
Just SUGGESTING
#Childbirth was never expected to hurt, can trigger many people who had bad experiences.

Every birth is both physical
AND psychological.
Christians tend to have painful births bc they are TERRIFIED.

The curse of Eve
works on believers.
Read 12 tweets
I am trained in #developmental #psychology and #neuroscince. I have been screaming the #teenagebrain is #underreconstruction from the rooftops! Am totally ashamed of my peers who wilfully ignore this. #neuroplasticity #frontallobes #psychologists #gender #rogd #trans #detrans
The teenage brain is under reconstruction. The prefrontal cortex is not fully developed until minimum aged 25. A bit longer for males. The prefrontal cortex is largely responsible for: decision making, planning, organisation, focusing, impulsivity, aka executive functions
Managing emotions, predicting consequences of one’s choices and moderating social behaviour. This is #science #facts Anyone who says otherwise is brainwashed by #ideology Shame on any professional who ignores this #gender #trans #detrans #shame
Read 46 tweets
Thread:
Some Phramacokinetics, Geno- & Reprotoxicity highlights, Moderna's report to EMA, mostly animal studies
ema.europa.eu/en/documents/a…
P. 47: "Low levels of #mRNA could be detected in all examined tissues except the #kidney, this included heart, lung, testis & also ..
2./ #brain tissues, indicating mRNA/LNP platform crossed the blood/brain barrier..liver is a common target organ of LNPs.."
P. 49: ".. coagulation changes included increase in fibrinogen, activated partial thromboplastin time .".
(generic image) 
P. 50, Genotoxicity: "significant
3./ increases in micronucleated erythrocytes were reported in both sexes" (Note: chance of genetic chromosomal damage to red blood cells)

P. 51, ReproToxicity: "The mRNA-1273-related non-adverse effects were limited to an increase in the number of foetuses with common skeletal
Read 8 tweets
Good afternoon to our speakers this afternoon Professor Julia Sinclair - @drjmas and Sam Chamberlain - @SrCham who will talk about Neurobiology and treatment of addictions: from substances to behaviours #RCPsychIC #Neurobiology #Addictions Image
Welcome to our first speaker Anne Lingford Hughes speaking to us about alcohol use disorder: clinical features, neurobiology and evidence-based treatment

#RCPsychIC #Neurobiology #Addictions Image
Who is in control the user or the drug?

#RCPsychIC #Alcohol #Addictions Image
Read 25 tweets
.ongoing.sub.#Thread

Working on some of the #July10th, 2020 footage - the only footage that exists - of #FPF's "high-risk takedown" of another Frederictonian.

The reason for me being there never really mattered, as you'll soon witness if you continue following along here.

1/
Walk softly, and run a custom-built, OC'd PC whenever you can. 😉🤘♥️🏴‍☠️

#July10th #NLE #DaVinciResolve #AMD #Ryzen5 #LiquidCooling

2/ Image
#UseYourTools, you've already/often got everything that you need no matter where you are.

3/
Read 9 tweets
In a meeting I watched today, microglia priming was mentioned in #LongCovid and #ME/CFS. It’s important to clarify what “microglia priming” means. Microglial priming does not mean that after a trigger has “cleared” microglia remain perpetually activated
2/ Instead, microglia priming goes like this 👉 When microglia or other glial cells detect #infection, injury, or inflammatory mediators, they enter a state of activation in which they change morphology and release their own neuroexcitatory inflammatory mediators
3/ Then, after activating, they retain a “primed” functional state which causes an even more robust response to *subsequent* infectious/immune/#inflammatory challenges. And as cells, microglia live long lives (they are not replaced as often as many other cell types)
Read 13 tweets
Delighted to share our latest preprint in which we describe a ubiquitous complexity architecture of large-scale brain activity - a "human complexome" that unifies important organizational principles of functional brain networks. biorxiv.org/content/10.110…
With @Schwaenina @LeoWaschke @AmyRomanello @martin_gell @Garrett_Neuro and @carstenfinke, we looked at the #variability of resting-state BOLD signals and found that the #brain shows spontaneous episodes of neural regularity that become apparent as transient "complexity drops".
The tendency of brain regions to engage in these complexity drops together strongly explained functional connectivity strength between them - convergent with the co-fluctuations described by @FarnazZEs @richardfbetzel - and reflected canonical resting-state networks. @bttyeo
Read 13 tweets
1/ 🧵Wisdom in Medicine
 
What’s going on here? And why it’s key in #COVID19
 
It’s quite simple: we finally had the #wisdom to ask Mr. D the right question! He and his wife encouraged us to use this picture to teach what we learned.
 
#PalliativeCare #MedTwitter #NurseTwitter
2/ What we learned was to switch the preposition!
 
Mr. D was a pre-#COVID patient. On this day, he was taken off the vent after a MONTH. The incessant mantra had been, “What’s the matter WITH Mr. D?” He was surprised when we asked, “What matters TO you, Mr. D?”
3/ He has a tracheostomy, as you can see. We insert this airway through the neck to improve #comfort when someone is on a vent well beyond 10 days. He’s more comfortable because he no longer has a tube in his mouth. We used a program called the #A2Fbundle to reduce his #delirium.
Read 13 tweets
Excited to share our latest work - we use pan-neuronal 2 photon imaging to dissect how the #brain integrates multiple internal states to guide #food #choice! Fantastic work by @Dahaniel who took on this challenging project almost solo! #drosophila biorxiv.org/content/10.110… 1/21
We wanted to know what changes in the brain when animals #crave #foods. How do different internal states interact to change neuronal processing of #food #taste to alter feeding decisions? And can we use neurogenetics to identify causal brain regions driving food choice? 2/21
We had shown that when flies are protein deprived they increase their preference for protein-rich food like yeast. Food taste is key when deciding what to eat. But does the metabolic state alter taste processing and how do internal states change decisions? 3/21
Read 21 tweets
Been saying for many yrs even decades that pain does kill. I felt very close 2 death just 5yrs ago when I couldn't lift my head, take noise, light etc. Went 2 dr + said if he can't help me I'd hv 2 call ambulance f/his office. He increased patch 12mcg 'n changed 4 better! 2/8
Fast forward to last mos. Hv had 1 crisis aftelr another 4 many yrs now. Most disturbing was my body runs away on me + am 99% crippled + bedbound. Nobody would listen + I didn't have co-pays 4 many needed tests! Cldn't get help f/anyone 4 many diff conditions + needed tests! 3/8
Read 10 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
1/

@US_FDA approved the #Qcollar jugular compression device to "protect athletes' brains during head impacts."

This decision was based on VERY FLAWED DATA and does NOT demonstrate the safety or effectiveness of the Q-collar.

Read detailed thread⬇️

bit.ly/3q9ZZJL
2/

Here is the text from the @FDADeviceInfo press release.

If you don't understand the highly nuanced #MRI technique known as DTI, these results sound straightforward and convincing.

THEY ARE NOT. Don't be fooled by these numbers!🤔

I will dissect these in the thread below. Image
3a/

"No significant changes" is based AVERAGE response, not individual.

First, an easy-to-understand analogy below.

If half the sample experiences an increase and half experiences a decrease, they can cancel each other out to falsely suggest "no change" when one does exists! Image
Read 24 tweets
#idboardreview 50 F recent dental infection presents 4d of fever, R headache, L weakness. MRI ring enhancing lesion & aspirate w/ GPC ‘balls of yarn’ 🧶 diagnosis? #medEd #idmedEd #IDtwitter
#streptococcus #anginosus species brain abscess from odontogenic source
MRI demonstrate a ring enhancing lesion in R frontal lobe with vivid central restricted diffusion. The enhancing component has a complete low T2 rim #brain abscess Ref: radiopaedia.org/cases/cerebral…
Read 8 tweets
Excited to share this new preprint biorxiv.org/cgi/content/sh…

Is #caffeinated #soda bad for children's #brain development? If so, which specific intellectual capacity is affected? It is a question that many parents and caregivers are asking daily but there is no clear guideline 1/n
Using the #ABCDstudy data, we addressed the question in this work, “Daily caffeinated soda intake is associated with impaired working memory and higher impulsivity in children” 2/n
Some soda contains #caffeine (Coca Cola, Mountain Dew, Dr. Pepper, etc). The physical side effects of caffeinated soda such as obesity have been well documented and the short-term effects of caffeine consumption (mostly in adults) are well known. 3/n
Read 16 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
"As QAnon influencers and their followers are pushed off mainstream platforms.... There, they may be exposed to more extremist content, like that of white supremacist and neo-Nazi groups."

So what is the right approach? No right answers.

npr.org/2021/01/31/962…
..soooo.. usually seek facts & ideas ...rather than go down rabbit holes of others’ 🤯

..but wow, some remaining QAnon-posting accounts are within 1-2 degrees of separation..

To FB’s credit, misinformation/disinformation posts get covered with a grey filter & this warning:
Since I am a Muslim woman on the highly armed alt right’s radar myself now

am curious to understand what kind of 👹 they perceive me to be - tho prefer to only a quick peek, not a deep dive

(Obviously @IlhanMN was not actually at any such training camp)

usatoday.com/story/news/fac…
Read 32 tweets
"#ChronicPain on the #Brain - 4 #Psychological Effects of Living With #pain"
1)
Researcg covering the different ways the brain processes pain show us that the brain reacts differently to short-term pain than it does to long-lasting pain. h-wave.com/blog/chronic-p…
2)contd....
When the body experiences the latter, it can change the #centralnervoussystem (CNS),& influence sensory, emotional,& modular circuits that would otherwise inhibit pain.
3)contind.....
#chronicpain is now looked at as a #neurological #disease of it's own- comorbid with symptoms of #anxiety and #depression

#mesh injured are suffering on many levels....
Pleaee do NOT underestimate the psychological impact of living with daily chronic #pelvicpain
Read 6 tweets
Somewhere in our conscious pursuit of patterns, grand order and #inspiration, we often miss something far more elemental – the delicate joy of connecting with #nature, beyond the practical function of existing in it.
It's how you #feel, when you stand gaping at a masterpiece in a gallery, and momentarily lose yourself into its contours. That is when your observation goes beyond being just "useful", burrows deep into the primal parts of your #brain, and tickles them with an awe.
Soaking in the occasional Sun outdoors is a rare delight, as more days of cold, cloudy #weather coming through. And every once in a while, fate rewards me with an exclusive close up of nature's masterpieces – an enchanting #honeybee, the other day.
Read 6 tweets

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