Today marks the end of an era: publication of the final philatelic vignette (authors.elsevier.com/a/1g-uM5qq8Xpp3) co-authored by Robert Kyle @MayoClinic. Bob turned 95 this year and decided to step down from helping prepare these. He published his first vignette @JAMA_current back in 1969!/1
This longstanding series focused on medical & scientific-themed postage stamps began in 1961. At the 109th Annual Meeting of @AmerMedicalAssn in the then-new convention center in Miami Beach, Florida in June 1960, John Mirt (1897-1968) discussed “Medical Pathfinders on Stamps”./2
At the time, Mr. Mirt – a devoted Freemason - worked in press relations for the AMA in Chicago. After the meeting, he was asked by then-editor of @JAMA_current John Talbott (1902-1990) to start composing short articles about physicians & scientists featured on postage stamps./3
This was about the same time JAMA began to feature artwork on its cover (1964) to reflect the humanism in medicine. One additional purpose of the stamp vignettes was to “fill in white space” at the end of published articles. Most, like this one about van Swieten, were not long./4
Here you can see a typical vignette “in situ” in a 1972 issue of @JAMA_current, featuring a Polish stamp with a rather unflattering portrait of Sir Isaac Newton (1643-1727), shoehorned into a small box at the end of an article about blood transfusion services...in New Jersey.🤪/5
Between 1961 and his death in May 1968, John Mirt published >200 “Medical Pathfinders on Stamps” vignettes. After Mirt died, George Fite (1904-1993), senior editor of JAMA from 1965-1974 and a famed leprosy pathologist, asked Bob if he would compile the vignettes into a book./6
Bob got interested in stamps in 1965 after injuring his back while examining a patient & being hospitalized for 40 days of bedrest. He bought a Scott catalogue and outlined every stamp about either cancer or blood transfusion, then tried to collect them./7 intheloop.mayoclinic.org/2019/05/02/dr-…
That was a common medical practice back then: prolonged #bedrest, usually as an inpatient, for many conditions. When my maternal grandfather developed myocarditis after a smallpox vaccine in 1963, for example, he was prescribed 6 weeks in bed. The VTE rate must have been high!/8
Bob asked his friend Marc Shampo, PhD (1924-2019) to help him with the book & vignettes. Marc was a passionate collector who joined Mayo’s staff in 1962 (a year after Bob started) to worked in publications. This pairing continued until Marc became too frail to continue in 2016./9
JAMA editor Fite asked Bob and Marc to continue the series John Mirt started. Between 1969 and 1984, Bob and Marc published more than 330 vignettes in @JAMA_current. Reading these now, the language seems a bit old fashioned, but they're still interesting./10
Bob described how he got started in stamps in an @ASCOPost interview in 2019 (ascopost.com/issues/april-2… Aided by the @AABB, Bob was a key driver behind the US 6c blood transfusion commemorative stamp in 1971 - here's a First Day Cover: /11
Bob also was interviewed @ASHClinicalNews in 2015 for the "PASH-ions" section. He noted, "I was awarded the John Brain Medal in the late 1960s. In 1980, I earned the Myrtle Watt Award for Medical Philately Journalism for the vignettes that I authored... ashpublications.org/ashclinicalnew…
...I [Bob Kyle] also became active in the American Topical Association @AmerTopical, a large philatelic organization, and became president of its Medical Subjects Unit for five years, as well as being named a Distinguished Topical Philatelist in 1982." @APS_stamps /13
In 1984, JAMA decided to go in a different direction and discontinued the vignettes. The editor of @MayoProceedings at that time, Robert G. Siekert (1925-2014), invited Bob & Marc to publish vignettes in the Proceedings, where they've lived ever since - 39 years and counting./14
In 2004 when I returned to @MayoClinic from @MRC_WIMM in Oxford, Bob asked me to join him and Marc in preparing vignettes. In his words, “Marc and I aren’t getting any younger.” This Murad vignette was the first one I was involved with of ~60 so far; it published October 2004./15
I'm not a very active collector, but I started collecting stamps as a small boy circa 1980, inspired by my paternal grandfather. He gave me these colorful 1934 National Parks imperforate stamps, which were some of his own favorites & which I mounted for display at his funeral./16
Recently I talked about stamp collecting (including the famous 1947 USA Luke Fildes 'The Doctor' stamp) and many other topics in an @ASCO “Oncology, Etc.” Podcast hosted by Dave Johnson and Pat Loehrer. Link to the 1st part here: auwpod.libsyn.com/oncology-etc-i… /17
Earlier vignettes were compiled into 3 “Medicine & Stamps” volumes - here are my copies. Volume 1 (red cover) was published by the AMA in 1970 (originally $4), vol. 2 (gold) by Robert Krieger Publishing in Huntington NY in 1980, vol. 3 (blue cover) by Mayo Foundation in 2004./18
At this point, about 6 vignettes are published per year. Editorial assistant Peg Wentz @MayoProceedings has been a steadfast champion of the series (thank you Peg!), and Mayo hematologist Tom Witzig is helping me write them now that Bob Kyle has stepped back./19
I’ve shifted them away somewhat from biography (fewer stamps honor individuals anyway. Next month is about these beautiful new USPS "Life Magnified" commemoratives & microscopy history. I intend to continue as long as @MayoProceedings is willing to keep publishing them./20End
Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1
After all, zebrafish get along just fine making blood cells in their “kidney marrow”, keeping @leonard_zon's lab running. Drosophila make blood-like cells in abdominal hubs, and frogs… frogs mix it up. Jeremiah Bullfrog & frog cousins make blood in kidneys, marrow, liver, etc./2
Hematopoietic stem cells (HSCs) are like seafarers or long-haul truckers: they have a tough, unforgiving job requiring long hours. They must generate >2×10¹¹ blood cells daily, over the course of an organismal lifespan that might span >100 years. (HSC time image: @Goodell_Lab)/3
I was reviewing marrow failure history in preparation for an upcoming @aamdsif conference, and I’m completely awed by the observational skills of young physician Paul Strübing in Greifswald, Germany in 1882 describing the first clear case of paroxysmal nocturnal hemoglobinuria./1
This was the only photo I could find of Strübing, from over 20 years later (circa 1905). At the time of publication of his prescient 1882 paper, Strübing was 29 years old and had graduated from medical school 6 years earlier. /2
As William Crosby @TuftsMedSchool wrote in 1951 @BloodJournal, “Strübing’s paper on [PNH] might well be regarded as a classic of clinical investigation. He recognized clearly that the disease was a new entity and characterized it by a careful description of his patient."/3
@OpenAI#ChatGPT4 "hallucinations" remind me of a now-amusing event from way back in Grade 3 when I was 7, involving the last time I knowingly confabulated. I was assigned to write a report about airplanes.✈️ One thing I already knew about airplanes: they were expensive! (1/12)
According to my parents, the high cost of airplane tickets was why our family always drove the tedious 800+ miles from our NYC suburban home to see relatives in Michigan at Christmas🎄If 4 airplane *tickets* were expensive, I reasoned an *entire airplane* must be hugely costly.
I found lots of good airplane info, which went into that report. But couldn't find ANYTHING about cost. I looked everywhere a kid could look in the 1970s: encyclopedias, school books, library books. Nothing. Desperate, I made up a plausible number 😲 and added it to the report.
I’ve never posted a @tiktok_us link before, but this is a rare opportunity to observe one of the most poorly understood disorders in #hematology: Gardner-Diamond syndrome. This young woman's skin lesions first appear about 40 seconds in./1 #MedTwittertiktok.com/@nancy.xoxx/vi…
The syndrome was described by Drs. Frank Gardner (1919-2013) and Louis K. Diamond (1902-1999) in Boston in 1955, in @BloodJournal. They reported 4 cases, all women, who had a peculiar form of bruising on face or extremities but had no other bleeding & normal coagulation tests./2
The key finding in Gardner-Diamond syndrome: unexplained painful bruises, most commonly on extremities or face, often during times of stress. The pathophysiology is unclear, as described below. Many patients have been dismissed by physicians as having a fictitious disorder./3
Among the many things I am #thankful for: recent progress in hematologic malignancies. When I started my career - not that long ago! - standard therapy for myeloma was melphalan & prednisone or VMP, chlorambucil for CLL, CHOP (without R) for NHL, epoetin & transfusions for MDS./1
CML was treated with Hydrea, busulfan, or interferon & Ara-C,and the big debate was transplant timing. Most patients didn't have an allo transplant donor & the age cutoff was 50-55. Karyotyping was inconsistently done even in AML/MDS; FISH was new; single gene testing was rare./2
No one knew about JAK2 mutations, let alone envisioning specific JAK2 inhibitors. There were elderly patients with polycythemia we treated with radiophosphorous. Many clinical trials were small IITs. The most "exciting" progress was in hairy cell leukemia: pentostatin & 2-CDA./3
A medical textbook nostalgia thread! I dug up my @UChicagoMed transcript & recalled what books we used for each class. Buying books online was rare back then, so most came from the University bookstore at 58th & S Ellis, or the claustrophobic but amazing @SeminaryCoop on 57th./1
Year 1, Term 1 (Autumn): Netter’s Atlas of Human Anatomy (1989 edition), Wheater’s Functional Histology (1987), Moore’s Developing Human: Clinically Oriented Embryology (1988), Stryer’s Biochemistry (1990). (If you had another biochem text from undergrad, you could use that.)/2
One weird fact about U of C medical school: back then med student skeletal anatomy was taught by paleontologists, including @NatGeo Explorer-in-Residence Paul Sereno (here's his Facebook image). So we learned not just about human anatomy, but how humans differ from dinosaurs.🦖🦕