Janiesaysyay Profile picture
May 5, 2023 β€’ 22 tweets β€’ 10 min read β€’ Read on X
Ironic

Dr Burkhardt's team published more autopsy data on COVID πŸ’‰ patients confirming lymphocytes in every organ; which means it's a good time to revisit this little gem of a paper, with many highly predictive statements about the LNPs in the
#WarpedSpeed πŸ’‰>
Before we start it's interesting to note the paper is from a team at Thomas Jefferson University.
The same 🏫 which forced their president to publicly apologize for liking @AlexBerenson's tweets questioning the safety and efficiency of the πŸ’‰s.
The research looked at data showing the highly inflammatory nature of the lipid nanoparticles when tested in 🐁, injected into the muscle, and intranasally. >
ncbi.nlm.nih.gov/pmc/articles/P… https://www.ncbi.nlm.nih.go...
Remember this fact about the PEG.
We'll come back to it later in the context of the #StringOfPearls 🧡
The last line is a hoot.
"However the potential inflammatory nature of these LNPs was NOT assessed."
Who has time for petty details when moving at the SPEED OF SCIENCEℒ️? > Image
They injected saline (PBS) vs the LNPs in the skin and the muscle and found: https://www.ncbi.nlm.nih.go...
In both skin and muscle the LNPs quickly provoke an inflammatory reaction, below the skin on the right gets noticeably red. > ImageImage
The far right is the inflamed muscle cell. > Image
They noticed an interesting effect > Image
Massive inflammation and increased weight in the muscle.
If the LNPs were to go off-target and circulate widely in the body, is there another muscle πŸ’— which might be affected? > Image
Thousands of genes were upregulated. > Image
"...we show that LNPs, alone or complexed with control noncoding poly-cytosine mRNA, are highly inflammatory in 🐁, likely through the engagement and activation of various distinct and convergent inflammatory pathways." > (E) Volcano plot summarizin...
Next, they inoculated the mice intranasally and found similar striking results. > https://www.ncbi.nlm.nih.go...
The LNPs made it look like the mice were chain smokers. > ImageImage
The higher the amount of LNPs, the quicker the death. > Image
On the left is saline injected mouse lung. On the right is the LNP-injected mouse lung, an image which may be somewhat familiar to followers of Dr. Burkhardt. > Figure 3B https://www.ncbi....
Image
Follow the dotted line. https://www.ncbi.nlm.nih.go...Image
> ImageImage
We've come to the end of this paper.
#KeepItComingLove #ILoveLucyJobSwitching #ImExhausted https://www.ncbi.nlm.nih.go...
Here is Dr. Burkhardt's 1st presentation, scroll down and "show replies" to see more of his work.

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More from @janiesaysyay

Sep 5
πŸ’Ž Another brilliant research paper from Pretorius et al.
#DiamondsOnTheSolesOfHerShoes

It's interesting to hypothesize what these findings might mean in light of the C0VID πŸ’‰'s mRNA/spike protein persistence in the body, and its accompanying dose of billions of lipid nanoparticles in systemic circulation. >Image
A theory > Image
> Image
Read 21 tweets
Aug 24
πŸ§¬πŸ’‰ So Into You ~ mRNA Integration πŸ’‰πŸ§¬

#DIM the lights, put on some slow music,

a new preprint from πŸ§‘β€πŸ”¬πŸ‘©β€πŸ”¬ at Jackson Lab is out looking at early transient innate immune responses in myeloid cells to the C0VID πŸ’‰

Their results inadvertently uncover another possible mechanism for integration of the C0VID πŸ’‰ RNA into the human genome.

🧡
tinyurl.com/y4nk5nhv
The scientists used single cell multi-omics programming, antibody and cytokine profiles to uncover:
"a distinct myeloid priming program induced by Type I interferons after the first mRNA dose, and a broader boosting response involving both Type I and Type II interferons after the second mRNA dose or Ad26.COV2.S." >Image
Image
They compared different expressions of genes in monocytes and dendritic cells and found that interferon stimulated genes (ISGs) were upregulated. > Image
Read 17 tweets
Jul 22
Creutzfeldt Jakob Disease

2 interesting papers on blood signatures for
Sporadic CJD.

Researchers found 38 different DNA methylation sites related to sCJD.

9 of these sites were replicated in a further study, with sites in or close to genes: FKBP5, AIM2, UHRF1, KCNAB2 successfully replicated, specific to sCJD.

These were specific to sCJD vs other prion disease, or AD and found only in the blood, not brains of sCJD patients, suggesting a possible blood biomarker.
>
tinyurl.com/bdnn7ysrImage
"Top 10 gene ontologies enriched in genes overlapping DMPs as identified using MetaCore (p value threshold = 0.1)." -Fig. 2
> Image
"Loss of DNA methylation at 2 sites on the AIM2 promoter correlates with disease severity.
AIM2 is a key component of the inflammasome pathway...drives IL-1Ξ²"
> Image
Read 10 tweets
Jun 24
Tendons are made of collagen.
SARS2 degrades collagen.
tinyurl.com/y37ryb6j x.com/SalvMattera/st…Image
Sorry, that should be dysregulates collagen in the muscles and bones. > https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.952278/full
> https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.952278/full
Read 8 tweets
Jun 5
⏳ Hanginaround 2 βŒ›οΈ

COVID-19 mRNA πŸ’‰ Component Persistence

🧡Image
⏳
> Image
βŒ›οΈ
> Image
Read 15 tweets
Jun 2
πŸ–‡οΈ Up Around the Bend πŸ–‡οΈ

Spike Amyloidogenesis Theory

🧡 Based on research by: Nystrom & Hammerstrom, Pretorius &  Kell, Kevin McCairn, Kevin McKernan, Walter Chesnut, Greg Harrison et al., me, and many others.
πŸ“Ž
> Image
πŸ“Ž
> Image
Read 21 tweets

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