Nicole Laurent, LMHC Profile picture
May 29 15 tweets 3 min read Twitter logo Read on Twitter
This thread is for all the new kids on the block who are here to learn the basics about what a ketogenic diet is and why everyone is going on about it! 🧵(1/15)
Ketone bodies are small compounds produced from fatty acids that serve as an alternative energy source for mitochondria when insulin levels are low, such as during fasting or intense exercise. Or a ketogenic diet! (2/15)
The most well-studied ketone bodies in humans are acetoacetate (AcAc) and β-hydroxybutyrate (BHB). (3/15)
Ketone bodies are believed to be adaptive molecules secreted by the liver and quickly distributed to vital organs as part of a survival mechanism. (4/15)
They were thought to evolve to provide bioenergetic and signaling advantages during life-threatening conditions or increased risk factors for premature death. (5/15)
But personally, I and many others have found them to be super useful for their health and brain function in non-impending death circumstances! 😆 (6/15)
I want you to understand that sustained and long-term ketosis with adequate nutrient intake is not a stressful thing for your body. There are some forward-thinking thinkers who are on to the possibility that this might be our bodies' preferred state. (7/15)
In a low enough state of carbohydrate consumption, the conversion of stored energy in adipose tissue into fuel for cellular functions happens. (8/15)
Ketones are derived from fatty acids released from adipose tissue, transported to the liver, and circulated throughout the body. (9/15)
Once taken up by cells, ketone bodies like BHB undergoes a breakdown in the mitochondria to generate acetyl-CoA, which further contributes to ATP production—the primary "energy currency" of your cells. (10/15)
Reducing carbohydrate intake leads to the depletion of the body's glucose reserves (this is good!), triggering ketogenesis (also good!), hepatic oxidation of fatty acids, and production of ketones as an important and I would state, superior energy source. (11/15)
Particularly if you have some insulin resistance or your noggin is not working well. Ketones are a superior fuel in those contexts. I promise. (12/15)
In addition to their metabolic function, #ketone bodies also play a role in signaling processes separate from #energy production. (13/15)
They are involved in epigenetic changes, cellular signaling metabolites. What does this mean? It means they are molecular signaling bodies that turn genes on and off! They are that powerful. (14/15) 🧬#nojoke
If you are curious about ketogenic diets, particularly for mental illness or neurological conditions (or even just a stubborn case of brain fog) you should check out my blog. (15/15)
mentalhealthketo.com

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More from @KetoCounselor

May 31
Because metabolic health IS mental health, we are going to break down this study in which the ketogenic diet just handed the Dash diet its ass. (Yes, I talk like this in real life). 🧵 (1/22)
Comparing Very Low-Carbohydrate vs DASH Diets for Overweight or Obese Adults With Hypertension and Prediabetes or Type 2 Diabetes: A Randomized Trial. Annals of family medicine, 21(3), 256–263. doi.org/10.1370/afm.29… (2/22)
First, how was it designed? I think very well! 94 adults w/triple multimorbidity (hypertension, prediabetes or type 2 diabetes, and overweight or obese). (3/22)
Read 22 tweets
May 30
It is not a bold statement for me to declare that no other diet is as well-researched as a ketogenic diet. But if that statement confuses you or gets your feathers ruffled, keep reading. ⬇️(1/11)
"Oh no, Nicole! That's not right. It's the Medittarean diet. That's the most researched!" (2/11)
And if that is your declaration, I think it is important to inform you that there is simply no consistent definition of a ketogenic diet in the scientific literature. All the data, therefore, is pretty willy-nilly, and we can't draw confident conclusions. (3/11)
Read 11 tweets
May 29
This thread provides some real talk about what is being called mental health support in the social media world and even in groups run by peers or trained mental health professionals. (1/11) #mentalhealthmatters
Sometimes the people attempting to provide a place for mental health support inadvertently do not. And if you are part of these support groups, either in person or online, I want you to watch out for something. (2/11)
Particularly if you are responding well and rapidly to the use of a #ketogenic diet for mental illness, with or without a therapy component, this is a real issue that comes up. (3/11)
Read 11 tweets
May 27
If you are a doctor warning people away from a ketogenic diet because of concerns about heart health, I don't know what research you are even reading at this point! Let me turn you on to a branch of the lit you may not be aware of. Keep reading. ⬇️ (1/17)
High-fat, low-carb ketogenic diet boosted endothelial cell growth in mouse hearts, even preventing blood vessel rarefaction in heart disease models. Suggests potential for dietary interventions in treating heart diseases. (2/17) doi.org/10.15252/emmm.…
How about this next one stating that evidence suggests anti-inflammatory effects of caloric restriction/keto diets could be due to BHB-inhibited NLRP3 inflammasome. (3/17) doi.org/10.1038/nm.3804
Read 17 tweets
May 26
Let's break down what this fun article is talking about regarding the sociability of mitochondria! I love me a good paradigm shift first thing in the morning. Don't you?! ☕🌞🧵(1/23)
The article discusses the concept of sociality, or the tendency to form social groups, as a phenomenon that exists across different levels of biological complexity. (2/23)
sciencedirect.com/science/articl…
All the cool kids do it! From unicellular organisms to multicellular animals. And mitochondria are no exception! But they have been traditionally viewed as individual entities. And finally, they are being fully recognized for their social behavior. (3/23)
Read 23 tweets
May 25
Considering impairment of mitochondrial function is a driver of oxidative stress (OS), it should come as no surprise that oxidative stress is part of what drives the disease process in Alzheimer's disease (AD). 🧵 (1/15)
"Indeed, considerable evidence suggests that OS occurs before the appearance of symptoms in AD and that oxidative damage is detected not only in the vulnerable brain regions but also in peripheral areas." (2/15) doi.org/10.3390/antiox…
For those new to this term, oxidative stress describes the imbalance that occurs in our bodies between harmful molecules called reactive oxygen species (ROS) and our ability to defend against them. (3/15)
Read 15 tweets

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