Discover and read the best of Twitter Threads about #ketone

Most recents (7)

This thread is for all the new kids on the block who are here to learn the basics about what a ketogenic diet is and why everyone is going on about it! ๐Ÿงต(1/15)
Ketone bodies are small compounds produced from fatty acids that serve as an alternative energy source for mitochondria when insulin levels are low, such as during fasting or intense exercise. Or a ketogenic diet! (2/15)
The most well-studied ketone bodies in humans are acetoacetate (AcAc) and ฮฒ-hydroxybutyrate (BHB). (3/15)
Read 15 tweets
Doesn't butyrate also convert into beta-hydroxybutyrate in the main ketone body? Is there some inner conversion in the gut? Are these used interchangeably? (1/11)
For the most part, the pools of butyrate in the gut and beta-hydroxybutyrate (BHB) are separate. Remember, #BHB is a #ketone body that is produced by your body on a #ketogenic diet. (2/11)
There are some bacteria that may be able to put the hydroxyl group onto butyrate to create BHB. But for the most part, butyrate produced in the gut is mostly from the fermentation of fibers and different prebiotics. (3/11)
Read 11 tweets
Migraine, a common neurological disorder, may be a metabolic as much as a neurological disease, with the migraine attack serving as a warning signal to increased oxidative stress and/or hypometabolism. (1/21) #neurotwitter #hypometabolism
Despite being primarily studied in terms of neuro-vasculature and neurotransmission, recent research suggests that migraine's pathogenic mechanisms may be linked to metabolism and mitochondrial dysfunction. (2/21) #mitochondria
Magnetic resonance spectroscopy studies have consistently shown decreased ATP levels and abnormal mitochondrial function in migraineurs, suggesting a metabolic component to the disorder. (3/21)
Read 21 tweets
Let's explore the outcomes of a study that explored the neurobiological evidence in support of improvement in depression with a ketogenic diet and find out what underlying biological mechanisms they uncovered through in vitro and in vivo studies.๐Ÿงต(1/29) #depression #ketogenic
Basically, they did a literature review from August 2021 to January 2022. Here's what they found. (2/29) #research
People with #depression may have changes in #glucose #metabolism in the brain. The #ketogenic diet boosts cellular #energy metabolism by raising #ketone bodies and replacing glucose as the main fuel source. (3/29)
Read 29 tweets
There are positive effects of the #ketone body beta hydroxy-butyrate (BHB) on vascular function. Why? Very likely, the following things that we already know BHB does. And quite frankly, there are likely additional mechanisms that haven't even been discovered yet. ๐Ÿงต(1/10)
BHB lowers high blood sugar, and that reduces the production of reactive oxygen species #ROS and #inflammation mediators. In other words, BHB reduces Oxidative Stress (2/10)
BHB increases endogenous #antioxidant production by upregulating gene expression in those pathways. So yes, #BHB reduces Oxidative Stress from that mechanism as well. (3/10)
Read 10 tweets
1/ Have you seen the New Non-Nutritive sweeteners paper in Cell making the rounds!?! Fantastic!

Here's a video rundown:

And this thread contains a brief tweetorial...
2/ This study took 120 young health people who didn't consume non-nutritive sweeteners (NNS) and broke them into 6 groups, n = 20/group
๐Ÿ‘‰ Control (no supplement)
๐Ÿ‘‰ Glucose
๐Ÿ‘‰ Sacchrin
๐Ÿ‘‰ Sucralose
๐Ÿ‘‰ Aspartame
๐Ÿ‘‰ Stevia
7 day baseline, 14 day exposure, and 7 day follow-up
3/ There was a clear individualized response across NNS, with Sucralose and Saccharin having the largest impact on glucose tolerance on oral glucose tolerance test.

There were "responders" (who had worse glucose tolerance in response to NNS) and also non-responders.
Read 11 tweets
The #ketone body, acetoacetate (AcAc) regulates lipid metabolism through receptor GPR43โ€ฆ

Cool study .@DaveKeto and I were discussing...

AcAc binds to the GPR43/FFAR2 receptor to promote Lipoprotein Lipase activity and help burn fat.

Some more details...
2/ Short-chain fatty acids (SCFAs) in the gut r known to modulate energy homeostatis. Butyrate, acetate, proprionate all have recptors. The acetate receptor is GPR43.

The ketone BhB is all well studied as a signaling molecule, and binds HCAR2 etc., but AcAc is less well studied.
3/ This paper provides good evidence that, during fasting and ketogenic conditions, its AcAc that helps promote fat burning (lypolysis) throughout the body (except in the gut, more on that in a bit). Again, AcAc binds GPR43 and promotes Lipoprotein lipase (LPL activity)...
Read 10 tweets

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