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Janiesaysyay

@janiesaysyay

May 31, 2023 • 10 tweets • 6 min read • Read on X

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https://twitter.com/shkhanmohammadi/status/1663505171257729024

MALAT1 & NEAT1

Long Non Coding RNAs, Lymphoma and COVID

Interesting paper on new potential biomarkers for aggressive lymphomas, LncRNAs.

It highlights the LncRNAs involved in lymphoma.

There are some similar LncRNAs dysregulated by COVID. >

https://twitter.com/shkhanmohammadi/status/1663505171257729024

MALAT1 and NEAT1 in Lymphoma >

MALAT1 & NEAT1 in COVID

"The study’s most significantly differentially expressed gene was NEAT1, which encodes a lncRNA in genomic proximity to MALAT1" >
ncbi.nlm.nih.gov/pmc/articles/P…

MALAT1 and NEAT1 are dysregulated in COVID >

Since we see a rise in lymphomas/aggressive lymphomas also after COVID💉,
what LncRNAs will be found dysregulated by the 💉 spike protein? >

#LncRNA #miRNA #NonCodingRNA #MALAT1 #NEAT1 #Lymphoma #DiffuseLargeBcellLymphoma #BurkittsLymphoma #MantleCellLymphoma #cancer

#WhiteLines #HighAnxiety #LymPHAdeN0Pathy
nzherald.co.nz/sport/kiwi-woo…

https://twitter.com/db11770382/status/1663702259585232901?s=20

https://twitter.com/db11770382/status/1663702259585232901?s=20

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More from @janiesaysyay

Janiesaysyay

@janiesaysyay

Sep 5

💎 Another brilliant research paper from Pretorius et al.
#DiamondsOnTheSolesOfHerShoes

It's interesting to hypothesize what these findings might mean in light of the C0VID 💉's mRNA/spike protein persistence in the body, and its accompanying dose of billions of lipid nanoparticles in systemic circulation. >

A theory >

Read 21 tweets

Janiesaysyay

@janiesaysyay

Aug 24

🧬💉 So Into You ~ mRNA Integration 💉🧬

#DIM the lights, put on some slow music,

a new preprint from 🧑‍🔬👩‍🔬 at Jackson Lab is out looking at early transient innate immune responses in myeloid cells to the C0VID 💉

Their results inadvertently uncover another possible mechanism for integration of the C0VID 💉 RNA into the human genome.

🧵
tinyurl.com/y4nk5nhv

The scientists used single cell multi-omics programming, antibody and cytokine profiles to uncover:
"a distinct myeloid priming program induced by Type I interferons after the first mRNA dose, and a broader boosting response involving both Type I and Type II interferons after the second mRNA dose or Ad26.COV2.S." >

They compared different expressions of genes in monocytes and dendritic cells and found that interferon stimulated genes (ISGs) were upregulated. >

Read 17 tweets

Janiesaysyay

@janiesaysyay

Jul 22

Creutzfeldt Jakob Disease

2 interesting papers on blood signatures for
Sporadic CJD.

Researchers found 38 different DNA methylation sites related to sCJD.

9 of these sites were replicated in a further study, with sites in or close to genes: FKBP5, AIM2, UHRF1, KCNAB2 successfully replicated, specific to sCJD.

These were specific to sCJD vs other prion disease, or AD and found only in the blood, not brains of sCJD patients, suggesting a possible blood biomarker.
>
tinyurl.com/bdnn7ysr

"Top 10 gene ontologies enriched in genes overlapping DMPs as identified using MetaCore (p value threshold = 0.1)." -Fig. 2
>

"Loss of DNA methylation at 2 sites on the AIM2 promoter correlates with disease severity.
AIM2 is a key component of the inflammasome pathway...drives IL-1β"
>

Read 10 tweets