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Nick Krontiris Profile picture
@nick_krontiris
May 31 • 6 tweets • 2 min read Twitter logo Read on Twitter
Using linear and non-linear Mendelian randomization analyses, this one suggests that a higher adiposity, as measured by BMI, is causally associated with an increased risk for rheumatic disease, an effect that is more pronounced in women for both gout and psoriatic arthropathy. Image
- A genetic predisposition to high BMI is was found to be causally linked to a higher risk of developing psoriatic arthropathy and inflammatory spondylitis.
- For psoriatic arthropathy and gout, sex-specific effects were observed, and for osteoarthritis, the effect of BMI was stronger in premenopausal compared to postmenopausal women.
- Gout and osteoarthritis showed causal effects of BMI that varied across the BMI range, a variation that also differed between sexes for gout.
- Previously identified causal effects of BMI on risk of developing rheumatoid arthritis, osteoarthritis, and gout in all individuals were confirmed.
Body Mass Index and the Risk of Rheumatic Disease: Linear and Nonlinear Mendelian Randomization Analyses (open access)

doi.org/10.1002/art.42…

#Obesity #InsulinResistance #MetabolicSyndrome

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More from @nick_krontiris

Nick Krontiris Profile picture
Jun 1
In this one, a higher cardiovascular risk, as assessed by the Framingham 10‐year cardiovascular disease risk score, was associated with poorer cognitive function among older adults living in the US. Image
- The Framingham 10‐year cardiovascular disease risk score is based on age, sex, smoking, total cholesterol, high‐density lipoprotein‐cholesterol, blood pressure, and diabetes.
- It was found to be associated with lower cognitive function among older adults, including overall cognition and particular domains of cognition, such as executive function and processing speed, and immediate and delayed memory.
Read 6 tweets
Nick Krontiris Profile picture
Jun 1
In this one, HMB supplementation was associated with improvements in muscle strength, physical performance and muscle quality (defined as the handgrip strength/fat-free mass ratio) in older adults with sarcopenia during a resistance exercise program. Image
- This randomized, double-blind, placebo-controlled study aimed to evaluate whether HMB supplementation can improve muscle strength, function, and body composition in older adults with sarcopenia.
- This study included subjects aged ≥60 years with sarcopenia which were assigned to the HMB group or the placebo group.
Read 8 tweets
Nick Krontiris Profile picture
Jun 1
This one found a bidirectional, dose-response relationship between handgrip strength and cognitive function in a multinational, European population with a mean age of 68.42 years. Image
- This study tried to analyze the longitudinal association between handgrip strength and cognitive performance in different cognitive functions according to sex in a European multicentric population.
- A longitudinal and bidirectional relationship between handgrip strength and three different cognitive functions was observed.
Read 10 tweets
Nick Krontiris Profile picture
Jun 1
This umbrella review finds that the evidence from meta-analyses of Randomised Controlled Trials overall suggests that resistance training is likely to be a suitable intervention for persons with sarcopenic obesity, although the results may be suboptimal, in general.
- This is the first umbrella review on sarcopenic obesity conducted to provide comprehensive insights into the effectiveness of different nutrition and exercise interventions for adults.
- Four systematic reviews with between 30 to 225 participants were included in the umbrella review.
Read 11 tweets
Nick Krontiris Profile picture
Jun 1
This systematic review and meta-analysis finds little evidence for or against recommending the dietary inclusion of legumes for the purpose of cardiovascular disease and type 2 diabetes prevention for healthy general populations.
- This study aimed to systematically review the evidence for associations between consumption of legumes and cardiovascular disease, type 2 diabetes and their risk factors among healthy adults using both observational and intervention studies.
- Findings from observational studies (generally with low legume consumption) did not support an association, although clinical trials did indicate some likely beneficial (although clinically small) effects on blood lipids and fasting glucose.
Read 4 tweets
Nick Krontiris Profile picture
May 31
In this one, sustained weight loss was associated with lower HbA1c at 10 years and improvement in lipid profile, while maintenance of ≥7% weight loss at 1 year was associated with decreased incidence of diabetic nephropathy at 10 years in patients with diabetes. ImageImage
- The study evaluated 129 patients with diabetes and obesity enrolled in a 12-week translational model of intensive lifestyle intervention.
- At 1 year, participants were divided into group A, who maintained <7% weight loss (n=61, 47.7%), and group B, who maintained ≥7% weight loss (n=67, 52.3%).

Follow-up was continued for 10 years.
Read 9 tweets

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