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challenges of recognizing the facets of #LongCOVID
It's like trying to solve the Rubik's cube with changing colors
It's like trying to solve the Rubik's cube with changing colors
SCOPIMED study of #LongCovid
Study population minimum 6 months post Covid, but average 9 months
He mentioned funding from @patientled
Study population minimum 6 months post Covid, but average 9 months
He mentioned funding from @patientled
Complex study design - deep phenotyping combined with provocation maneuver and longitudinal follow-up
Passive exercise with massage cuff, but in #MECFS induces PEM in 90 minutes. Extract plasma and PBMCs, use braincheck test, first morning urine, exoskin to measure HRV
Passive exercise with massage cuff, but in #MECFS induces PEM in 90 minutes. Extract plasma and PBMCs, use braincheck test, first morning urine, exoskin to measure HRV
Participants complete questionnaires. How severe was their PEM?
Repeat at 3, 6, and 12 months with stress test. Are they improving? Regressing?
Repeat at 3, 6, and 12 months with stress test. Are they improving? Regressing?
Study circulating micro RNA. Searching for #MECFS signature in #LongCOVID
DNA makes messenger RNA which gives instructions to make proteins
Micro RNA are non-coding epigenetic regulators, attach at the end of the messenger RNA. Block protein production. 1 micro RNA can target hundreds of genes
Micro RNA are non-coding epigenetic regulators, attach at the end of the messenger RNA. Block protein production. 1 micro RNA can target hundreds of genes
Published paper in 2020 of 11 micro RNA in #MECFS
Do profile before and after the PEM inducing stress test to establish variation in micro RNA.
Do profile before and after the PEM inducing stress test to establish variation in micro RNA.
Combined diagnostic analysis of 11 circulating micro RNA and RFM. Machine learning gave 6 subtypes
evaluation of cognitive dysfunction in #LongCovid
See three clusters. Cluster A severe decline in memory.
See three clusters. Cluster A severe decline in memory.
brain oximetry alterations among LC and ME
High plasma SMPDL3B levels correlate with low cerebral O2 levels.
High plasma SMPDL3B levels correlate with low cerebral O2 levels.
Can stratify #LongCovid into different groups. FM-like, ME-like, ME+FM
patients with high FGF-21 have lots of fatigue and PEM
patients with high FGF-21 have lots of fatigue and PEM
Difference in ME group if taking LDN in FGF-21
If patient has high FGF-1, clinician could try LDN
If patient has high FGF-1, clinician could try LDN
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