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65 million people world-wide have #MECFS, same number have #LongCOVID now
Has occurred in outbreaks, some with polio outbreaks
Has occurred in outbreaks, some with polio outbreaks
#MECFS symptoms: fatigue, unrefreshing sleep, orthostatic intolerance, cognitive impairment, sore throat, fever, muscular pain, etc
Pre-2020 #MECFS mostly post-viral illness
Majority of patients identify infection as cause
What about those who suspect other causes? She thinks maybe they were from asymptomatic viral infections, not emotional stress, physical injuries, mold, etc.
Majority of patients identify infection as cause
What about those who suspect other causes? She thinks maybe they were from asymptomatic viral infections, not emotional stress, physical injuries, mold, etc.
Sx of #LongCOVID can arise after asymptomatic or mild acute illness
Enteroviruses and SARS COV2 can cause long-term infections
We don't know if people with #LongCOVID have persistent infection, but people who are immunocompromised have kept SARS CoV2 in their body over a year
We don't know if people with #LongCOVID have persistent infection, but people who are immunocompromised have kept SARS CoV2 in their body over a year
leading theories of ME/CFS
structural damage leading to neurological issues
pathogenic antibodies
persistence of abnormal biochemistry
chronic viral infection
structural damage leading to neurological issues
pathogenic antibodies
persistence of abnormal biochemistry
chronic viral infection
Is there any evidence for chronic viral stimulation of immune system in pre-2020 ME?
Evidence for chronic stimulation of the immune system
Evidence for chronic stimulation of the immune system
Metabolism of immune cells
CD4 T cells and CD8 T cells, CD8 most interest to her. They cause death of virus infected cells.
T cells become activated when interact with dendritic cells and then go and destroy infected cell
CD4 T cells and CD8 T cells, CD8 most interest to her. They cause death of virus infected cells.
T cells become activated when interact with dendritic cells and then go and destroy infected cell
Metabolism of T cell changes when activated. Abnormal CD8 T cell in ME/CFS - decreased glycolysis. Fatty acid oxidation is increased, likely compensatory mechanism
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