Thread by @nick_krontiris

In this one in individuals with prediabetes, long-term almond consumption was associated with adverse effects on insulin sensitivity and glucose metabolism, as they were added to the habitual diet and did not fully replace other foods.

- This study tried to examine the effects of long-term almond consumption in males and females with prediabetes on glucose metabolism side-by-side via the clamp technique, in the postprandial state, and in real life conditions using continuous glucose monitors.

- Forty-three participants volunteered in this randomized, cross-over trial with a 5-months control and intervention period and a 2-months wash-out.

- In the intervention period, participants daily consumed 50 g whole almonds.

- Results suggested a lowered whole-body insulin sensitivity as measured by the hyperinsulinemic euglycemic clamp and increased postprandial glucose responses after the almond intervention.

- The AUC for 24 h continuous glucose concentrations did not reach statistical significance, but fasting insulin concentrations were also likely to be increased.

- Increased BMI, waist circumference, and energy intake were observed after the almond period, suggesting that almonds were added to the habitual diet and did not fully replace other foods.

Interestingly, whole-body insulin sensitivity expressed as the M-value was likely to be lower at the end of the almond intervention period compared to the control period.

The treatment effect of almonds on the M-value was estimated at + 3.15 mg/kg/min, whereas the same model without BMI as covariate estimated the treatment effect at + 3.78 mg/kg/min.

These findings indicate that the BMI increase could only partly explain the adverse effect on insulin sensitivity.

The effects of long-term almond consumption on whole-body insulin sensitivity, postprandial glucose responses, and 48 h continuous glucose concentrations in males and females with prediabetes: a randomized controlled trial (open access)

doi.org/10.1007/s00394…

#nutrition #diet