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Daniel Gewolb, MD

@daniel_gewolb

Jun 10, 2023 • 14 tweets • 10 min read • Read on X

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@The_ASPNR

Differential Diagnosis for cortically based masses

P-DOG 🐶

1️⃣Pleomorphic Xanthoastrocytoma (PXA)
2️⃣Dysembryoplastic neuroepithelial tumor (DNET)
3️⃣Oligodendroglioma
4️⃣Ganglioglioma
#Neurology #neurosurgery #peds #radres #neurotwitter @The_ASPNR @TheASNR #MedTwitter

1️⃣PXA

Originate in the subpial astrocytes typically in children and young adults often with a seizure history

Temporal lobe is most common

Imaging (variable):

▶️Classically appear as a cortically based mass with cyst and enhancing nodule and overlying DURAL TAIL or enhancing leptomeninges

▶️Calcifications are RARE

▶️Can look very similar to ganglioglioma though calcifications are rare in PXA and if you’re lucky enough to have a dural tail/enhancing leptomeninges then PXA is favored

▶️Companion case of another PXA below

2️⃣DNET

▶️Cortically based mass in children and young adults presenting with long-standing seizures

▶️Most frequently occurs in temporal and frontal lobes

Imaging:

▶️Classically presents as a well demarcated cortically based “BUBBLY” mass with HYPERINTENSE RIM AROUND CYSTS ON FLAIR

▶️Usually there is NO ENHANCEMENT (though can have punctate or ring enhancement). However, when enhancement is seen, consider the possibility of more aggressive tumors.

▶️Companion case below of another DNET

3️⃣Oligodendroglioma

▶️Cortically based mass mainly in ADULTS

▶️Location: FRONTAL and temporal lobes most common

Imaging:
▶️Classically presents as a gyriform cortical/subcortical based mass with GYRIFORM OR CLUMPED CALCIFICATIONS

▶️Consider this diagnosis in an ADULT WITH A CALCIFIED FRONTAL MASS

4️⃣Ganglioglioma

▶️Occurs in children and young adults

▶️Location: Temporal lobe (most common)

Imaging (variable and can look very similar to PXA):

▶️Classically presents as a cystic and solid mass in the temporal lobe in a child/young adult with seizures

▶️Presence of CALCIFICATIONS & LACK OF DURAL TAIL may help to differentiate from PXA

Companion case of another ganglioglioma

💡 Learning points/summary:

P-DOG 🐶

1️⃣PXA: Cyst w/ enhancing mural nodule with DURAL TAIL/leptomeningeal enhancement and NO CALCIFICATIONS

2️⃣DNET: BUBBLY well demarcated mass with NO ENHANCEMENT

3️⃣Oligodendroglioma: Gyriform mass in frontal lobe of an ADULT w/ CALCIFICATIONS

4️⃣Ganglioglioma: Cyst w/ enhancing nodule in temporal lobe w/ CALCIFICATIONS and NO DURAL TAIL

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More from @daniel_gewolb

Daniel Gewolb, MD

@daniel_gewolb

Aug 1

⭐️What is the most likely diagnosis in this patient presenting with a lump on the head?

More images in 🧵

#MedEd #medicine #neurology #neurosurgery #ENT #radres #peds @Radiopaedia #futureradres @AlbanyMedRadRes

More images 👇

⭐️ Answer: Intradiploic epidermoid cyst

▶️CT shows a circumscribed low density skull mass with smooth scalloped margin suggesting a benign lesion

▶️Density/signal intensity is near CSF with the exception of FLAIR which shows incomplete suppression (dirty signal not black like CSF)

Read 6 tweets

Daniel Gewolb, MD

@daniel_gewolb

Jul 19

🔷What is the most likely diagnosis and clinical syndrome in this patient with left ear pain, cranial nerve 6 palsy, and retro-orbital pain? 🧠 🤔

#Neurology #ent #neurosurgery #radres #NeuroTwitter #futureradres #MRI #Medicine @ASHNRSociety @RSNA #Ophthalmology

⭐️ Answer: petrous apicitis complicated by brainstem abscess

🔷Petrous apicitis can display the clinical triad of Gradenigo’s syndrome

1️⃣Otorrhea
2️⃣Cranial nerve 6 palsy
3️⃣Pain in distribution of trigeminal nerve

▶️Petrous apicitis usually occurs as a complication of otomastoiditis when the infection spreads to the skull base.

▶️The petrous apex is in close proximity to Dorello’s canal (where cranial nerve 6 runs through) and Meckel’s cave (where the trigeminal ganglion is located)

Read 6 tweets

Daniel Gewolb, MD

@daniel_gewolb

Jul 4

⭐️ What is the most likely diagnosis in this pregnant patient presenting with seizures? 🧠

#Neurology #medicine #radres #futureradres #Neurosurgery #MRI #FOAMed

⭐️ Answer: Cortical vein thrombosis (CVT)

▶️CVT causes retrograde venous pressure leading to focal vasogenic edema

▶️Increased back pressure is characterized by dilated veins and petechial hemorrhage which can progress to large hematomas and ischemic neurological damage

🔷Two types of edema can develop:
1️⃣Vasogenic (from venous back pressure)
2️⃣Cytotoxic (ischemia)

🔷Risk factors:
💡 Up to 20% are idiopathic
1️⃣Trauma
2️⃣Tumor/malignancy (compression/invasion from meningioma)
3️⃣Infection
4️⃣Hormonal (pregnancy)
5️⃣Dehydration

Read 7 tweets

Daniel Gewolb, MD

@daniel_gewolb

Jun 22

🔷What is the most likely diagnosis in this 70 y/o F who lives with feral cats presenting w/ vomiting, diarrhea, leukocytosis, fever for 3 days and progressive decline in level of consciousness?

🔷CSF: initially normal, repeat a few days later ⬆️ WBC (lymphocyte predominant), ⬆️ Protein, normal glucose

⭐️ Answer: Viral encephalitis (Specifically Rabies)

🔷 South Central Asia and Southeast Asia appear to have the greatest number of cases

🔷Dogs are the most common reservoir 🐶 (bats in developed countries🦇)

🔷CLINICAL:

▶️Incubation period typically 3 weeks to 2 months (range 5 days to 6 months)
▶️Prodromal symptoms: fever, malaise, anxiety,
and itching at the inoculation site

💡Once in the body, the virus begins retrograde flow to extend to the dorsal root ganglion, which may correlate with neuropathic pain

▶️CNS manifestations: Mental status changes of excessive agitation and depression with hydrophobia and aerophobia

Read 5 tweets

Daniel Gewolb, MD

@daniel_gewolb

Jun 19

🔷35 y/o F w/ history of Li Fraumeni syndrome presents w/ intermittent left sided weakness and pain. The feeling is of heaviness, difficulty w/ grip, dropping objects and frequent falls. Episodes last for weeks to months. What is your diagnosis? 🧠

🎉Congrats to all the rad fellow matches today!!! 🍾

#Neurology #MRI #MedEd #medicine #neurosurgery #radres #futureradres #FOAMed @TheASNR

⭐️ Answer: Tumefactive demyelination (MS in this case)

🔷Imaging in this case is specific enough to diagnosis with confidence but we need extra caution in patients with genetic predisposition to malignancy

💡 In cases where imaging or clinical picture are atypical or discordant for demyelination (especially if there is a genetic disorder), it is best to refer to neurology for proper work up, possible trial of steroids and short imaging follow up

🚩 Be suspicious against MS if your patient has:
1️⃣Systemic symptoms (fever, weight loss, joint or skin symptoms, etc.)
2️⃣Seizures, hearing loss, meningitis signs, movement disorder, aphasia
3️⃣”Family history”
4️⃣Age (<20 or >50)
5️⃣Lesions are symmetric
6️⃣Hemorrhage or dense on CT
7️⃣Diffusion restriction other than leading edge
8️⃣Strokes
9️⃣Cysts
🔟Cortical infiltration

Read 6 tweets

Daniel Gewolb, MD

@daniel_gewolb

Apr 26

⭐️ What is the most likely diagnosis in this 45 y/o M found down with history of polysubstance abuse?

#Neurology #Medicine #radres #Neurosurgery #futureradres #radres #FOAMed #MRI @AlbanyMedRadRes @TheASNR

⭐️ Answer: Opioid-associated amnestic syndrome

🔷Toxicology was + for fentanyl and no other parts of the brain were affected on MRI

🔷Pathophys: Unclear, possibly neuronal hyper metabolism and/or ischemic component

🔷Clinical: New-onset amnesia for >24 hours

🔷Imaging:
▶️Diffuse, symmetric diffusion restriction in the hippocampi

▶️Usually mild T2/FLAIR signal in same areas

Read 7 tweets

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