Nick Krontiris Profile picture
Jun 13 11 tweets 3 min read Twitter logo Read on Twitter
The findings of this study suggest that inflammation (glycated proteins and small:total HDL particle ratio) and muscle metabolism (creatinine, creatine) may play a substantial role in the development of type 2 diabetes. Image
- The aim of this study was to combine nuclear magnetic resonance-based metabolomics and machine learning to find a glucose-independent molecular signature associated with future type 2 diabetes mellitus development.
- A case-control design nested in a population-based cohort (Di@bet.es study) was used in this study.
- The Di@bet.es Study is the first national study in Spain to examine the prevalence of diabetes and impaired glucose regulation.
- It consisted of 4700 individuals with metabolomic data available (43% men), with ages ranging from 18 to 93 years old, of whom 2181 participated in the follow-up 8 years later.
- Glyc A was the strongest predictor of diabetes mellitus, whereas Glyc B, Glyc F and the small to total particle ratios of HDL were all associated with a lower risk of developing type 2 diabetes mellitus.
- Moreover, creatinine and creatine were also associated with a lower risk of developing type 2 diabetes.
- Some other variables were also found suggestive of being associated with the risk of developing type 2 diabetes:
Acetone, lactate, histidine, TG to cholesterol ratios of LDL and small to total particle ratios of LDL were associated with an increased risk, while alanine and TG to cholesterol ratios of HDL were associated with a decreased risk of developing type 2 diabetes.
Finally, analysis also suggested that, at high Glyc B levels, the effect of Glyc A on diabetes development was no longer statistically significant.
NMR-based metabolomic profiling identifies inflammation and muscle-related metabolites as predictors of incident type 2 diabetes mellitus beyond glucose: The Di@bet.es study

doi.org/10.1016/j.diab…

#MetabolicSyndrome #Cholesterol #Triglycerides #Inflammation #Obesity #Diabetes

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Jun 16
This systematic review finds that overall the literature suggests that daily low-carbohydrate intake is not likely to negatively affect psychological well-being, or that this type of diet is worse than any other in this respect. Image
- This systematic review evaluated the impact of a carbohydrate-restricted or ketogenic diet on psychological outcomes.
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Jun 15
The findings of this one in mice suggest that dietary nitrate is capable of preserving mitochondrial bioenergetics during skeletal muscle disuse, and maintain mitochondrial-specific function during short-term (but not long-term) limb immobilization. Image
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- Since dietary nitrate can improve mitochondrial bioenergetics, this study examined whether nitrate supplementation attenuates disuse-induced impairments in mitochondrial function and muscle protein synthesis rates.
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Jun 15
Here, compared with men at the lowest end of the normal BMI spectrum, increased risk for an early acute coronary event was detectable already within the normal range of BMI at the age of 18 years, increasing to >5‐fold in the highest weight category at the age of 40 years. Image
- Coronary heart disease remains the dominant cause of death worldwide.
- This study aimed to determine whether body mass index at conscription predicts early acute coronary events among men in Sweden.
Read 7 tweets
Jun 15
This one found that among patients with newly diagnosed diabetes, a reduction in exercise frequency was related to increases in the risk of pneumonia and upper respiratory tract infection in Korean adults. Image
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Jun 15
Here, a triple agonist that interacts with GLP-1, neuropeptide Y1&Y2 receptors, regulated insulin secretion in rat and human pancreatic islets, promoted insulin-independent Y1-R-mediated glucose uptake in rat muscle tissue ex vivo and reduced food intake and body weight in rats. Image
- Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY).
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Jun 15
This one in mice suggests that chronic inflammation, and specifically IL-6 levels, may lead to increases in frailty and physical decline due to skeletal muscle changes that are mediated by changes in mitochondrial regulation and autophagy. Image
- This study focuses on a humanized inducible IL-6 model "due to the significant homology between mouse and human IL-6 at the amino acid level".
- The goal of this study was to better understand the role of IL-6 in frailty.
Read 8 tweets

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