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Al-Ola A Abdallah MD (USMIRC) Profile picture
@Abdallah81MD
Jun 17, 2023 • 7 tweets • 11 min read • Read on X
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Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, can also be found in reactive cells. imagebank.hematology.org/image/3230/fla… #mmsm #myeloma #MedTwitter #USMIRC #MedEd ImageImage
Mott cell is a plasma cell characterized by an accumulation of multiple Russell bodies, globular cytoplasmic inclusions composed of immunoglobulin imagebank.hematology.org/image/61837/mo… #mmsm #myeloma #MedTwitter #MedEd #USMIRC ImageImage
Russell bodies are cytoplasmic inclusions filled with immunoglobulins imagebank.hematology.org/image/4192/rus… #mmsm #myeloma #MedTwitter #MedEd #USMIRC ImageImage
Dutcher bodies (arrow) are intranuclear inclusions found in plasma cells. imagebank.hematology.org/image/1073/dut… #mmsm #myeloma #MedTwitter #MedEd #USMIRC ImageImage
Binucleated plasma cell. atlas.gechem.org/index.php?opti… #mmsm #myeloma #MedTwitter #MedEd #USMIRC ImageImage
inclusion bodies in plasma cells have been repeatedly reported, mainly concentrated in the Auer rod-like inclusions link.springer.com/article/10.100… #mmsm #myeloma #MedTwitter #MedEd #USMIRC ImageImage
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More from @Abdallah81MD

Al-Ola A Abdallah MD (USMIRC) Profile picture
Nov 26
🧵 All #ASH25 abstracts for #mmsm in a tweet 10+ Bonus:

1/10: Presentation ID 2387 
OL-101, a BCMA/GPRC5D dual-targeting autologous CAR-T for relapsed/ refractory multiple myeloma (R/R MM): Results from a Phase I study

#mmsm #Myeloma #USMIRC #MedEd #MedTwitter @USMIRCNEWS @MedwatchKate @Larvol @US_HMC #سرطان_الدم #المايلوما
2/10: Presentation ID 253 
Combined biparatopic nanobody-based B cell maturation antigen chimeric antigen receptor T cell therapy and pomalidomide for relapsed or refractory multiple myeloma: In-vitro characterisation and phase 1 dose-escalation study

#mmsm #Myeloma #USMIRC #MedEd #MedTwitter @USMIRCNEWS @MedwatchKate @Larvol @US_HMC #سرطان_الدم #المايلوما
3/10: presentation ID 2280 
Phase 2 study of aponermin +kt-decp in patients(pts) with Relapsed/Refractory multiple myeloma and extramedullary disease

#mmsm #Myeloma #USMIRC #MedEd #MedTwitter @USMIRCNEWS @MedwatchKate @Larvol @US_HMC #سرطان_الدم #المايلوما
Read 11 tweets
Al-Ola A Abdallah MD (USMIRC) Profile picture
Nov 21
7/10 Abstract from #ASH25:

1/🚀 Phase 2 IMMUNOPLANT Study Update!
Exploring abbreviated, fixed-duration (4 cycles) linvoseltamab (Linvo) immuno-consolidation to deepen responses in newly diagnosed multiple myeloma patients who remain MRD-positive after triplet/quad therapy.
A study from USA 🇺🇸
#Myeloma #Oncology

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert @MedwatchKate @Larvol @US_HMC #المايلوما #سرطان_الدم
2/🧬 Why this matters:
Even with modern quadruplet regimens (PI + IMiD + anti-CD38), about 50% of NDMM patients stay MRD-positive.
Linvoseltamab (a CD3xBCMA bispecific) may push responses deeper — without HDM-ASCT for those who defer it.
#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert @MedwatchKate @Larvol @US_HMC #المايلوما #سرطان_الدم
3/📝 Study design:
✔️ Single-center Phase 2
✔️ Up to 25 evaluable NDMM pts
✔️ Must have VGPR+ but MRD-positive by clonoSEQ
✔️ Receive 4–6 cycles of Linvo (step-up dosing)
✔️ Primary goal: MRD conversion
Secondary goals: sustained MRD-negativity, PFS, OS, safety

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert @MedwatchKate @Larvol @US_HMC #المايلوما #سرطان_الدم
Read 10 tweets
Al-Ola A Abdallah MD (USMIRC) Profile picture
Nov 16
5/10 ASH abstracts in #myeloma #ASH25
This one must make the list!!

🧵1/🚀 Promising new real-world data from China 🇨🇳!

Equecabtagene autoleucel (eque-cel) after ASCT shows strong safety & efficacy in ultra–high-risk multiple myeloma (UHR-MM) patients.
#MedEd #MedTwitter #mmsm #myeloma #USMIRC @USMIRCNEWS @MedwatchKate @Larvol @US_HMC @OncoAlert @oncodaily #سرطان_الدم #المايلوما
2/🧬 Why it matters:
UHR-MM patients still face poor outcomes despite advances in MM therapy. New strategies are urgently needed. Eque-cel, a BCMA-CAR-T therapy, is being explored earlier in treatment.

#MedEd #MedTwitter #mmsm #myeloma #USMIRC @USMIRCNEWS @MedwatchKate @Larvol @US_HMC @OncoAlert @oncodaily #سرطان_الدم #المايلوما
3/🧪 Study design:
Retrospective review of 12 UHR-MM patients treated with ASCT ➜ eque-cel (Day 2–4).
UHR defined by:
• High-risk cytogenetics (del17p ≥60%, TP53, t(4;14), etc.)
• Primary refractory disease
• Early relapse
• Primary PCL history

#MedEd #MedTwitter #mmsm #myeloma #USMIRC @USMIRCNEWS @MedwatchKate @Larvol @US_HMC @OncoAlert @oncodaily #سرطان_الدم #المايلوما
Read 10 tweets
Al-Ola A Abdallah MD (USMIRC) Profile picture
Nov 14
from #ASH25 Day 3:
3/10;
🧵 Thread: Phase 2 Study of Aponermin + KT-DECP in RRMM with EMD a study from China 🇨🇳 Kudus for the group to design a study focusing on EMD 👍🏻👏🏻👏🏻

1️⃣ 🔬 RRMM with extramedullary disease (EMD) remains a high-risk population (3-yr OS ≈ 58%).
Aponermin (Apo), a DR4/DR5 agonist, activates the extrinsic apoptosis pathway via caspase signaling.
This trial evaluated Apo + KT-DECP in RRMM + EMD.

#USMIRC @USMIRCNEWS @OncoAlert @US_HMC @MedwatchKate @Larvol #MedTwitter #MedEd #mmsm @ASH_hematology #المايلوما #سرطان_الدم
2️⃣ 🧪 Study Design
•Multicenter, single-arm phase 2 (NCT05013190)
•Planned N=31; current N=23
•EMD confirmed per IMWG
•Apo-KT-DECP for 4–6 cycles; RT added if •Primary endpoint: ORR after 2 cycles
•Secondary: CR, ≥VGPR, time to response (TOR), safety

#USMIRC @USMIRCNEWS @OncoAlert @US_HMC @MedwatchKate @Larvol #MedTwitter #MedEd #mmsm @ASH_hematology #المايلوما #سرطان_الدم
3️⃣ 👥 Patient Characteristics
•Median age: 62 yrs
•Prior lines: 3 (range 1–9)
•43.5%: ≥3 EMD sites
•60.9%: mixed bone-independent + paraskeletal lesions
•30.4%: large EMD ≥5 cm
•High-risk cytogenetics: 37.5%
•Anaplastic/blastoid: 4 pts
•Malignant pleural effusion: 2 pts
•TCR: 56.5%
•No prior BCMA exposure

#USMIRC @USMIRCNEWS @OncoAlert @US_HMC @MedwatchKate @Larvol #MedTwitter #MedEd #mmsm @ASH_hematology #المايلوما #سرطان_الدم
Read 7 tweets
Al-Ola A Abdallah MD (USMIRC) Profile picture
Nov 5
🚨The Future of BiTEs, especially in combination therapy trials, should be focused on fixed duration 👍 👍👍

🧵 Teclistamab Dosing Strategies in #MultipleMyeloma: Continuous vs. Fixed-Duration Therapy :

1/Study Snapshot
📊 Multicenter, real-world retrospective analysis (n=88)
💊 Compared continuous (n=72) vs. fixed-duration (n=16) teclistamab in relapsed/refractory #MM
🎯 Goal: Evaluate if stopping after deep response compromises outcomes

#ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوما @oncodaily @MedwatchKate @MDPIOpenAccess @CancerNetwrk @KUcancercenter @SaudiMyeloma #السعوديةImage
2/Core Finding
✅ Fixed-duration strategy appears feasible for select patients
📈 12-mo PFS ~same: 65% (continuous) vs. 66% (fixed)
⚠️ BUT: Severe infection risk 🚨 much higher in fixed-duration group (69% vs. 22%)

#ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوما
3/ Patient Differences Matter
👵 Fixed-duration pts were older (median 73y vs. 69y)
💥 More prior BCMA-therapy refractory (56% vs. 29%)
🧬 Similar rates of high-risk cytogenetics (~43%)
🦾 Heavily pretreated: median 5 prior lines

#ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوماImage
Image
Read 9 tweets
Al-Ola A Abdallah MD (USMIRC) Profile picture
Oct 15
An Interesting Paper ⬇️⬇️⬇️
🧵 Prognostic Value of Splenomegaly in BCMA CAR-T Therapy for Myeloma

📍Study from Univ. Hospital Leipzig explores whether spleen size can predict outcomes in RRMM patients receiving BCMA-CAR-T (ide-cel or cilta-cel).
#Myeloma #CARTcell #HemOnc #Immunotherapy

#ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوماImage
1️⃣ Why spleen size?
🩸 CAR-T success varies widely. Existing scores (EASIX, CAR-HEMATOTOX, sBCMA) predict toxicity & survival—but none account for immune sequestration or EMH.
👉 Hypothesis: an enlarged spleen = immune “sink” that impairs CAR-T expansion.

#ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوماImage
2️⃣ Study design
📊 N=73 RRMM pts (ide-cel 35, cilta-cel 38)
Median age 64; 74% triple-class refractory.
Splenomegaly > 340 cm³ by CT.
Endpoints: PFS, OS, thrombocytopenia, CAR-T expansion.

#ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوما
Read 11 tweets

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