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Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
@CiaraGlenville
Jun 19 • 7 tweets • 5 min read Twitter logo Read on Twitter
Is there a link between @remissionbiome and #TheNicotineTest? Could the DMN be a major key? Going to post some threads/ tweets here and then go off to research! Anyone who has the interest and the spoons, join in! #LongCovid #mecfs #pwME #vaccineinjured
DMN regulation in PEM/ link to the health rising article in @tessfalor ‘s *excellent* thread here
DMN regulation by nicotine
Clavulonic acid in AmoxClav influence on the DMN
And there’s more..
@KarenStump8 @chydorina @KatBoniface @TheNicotineTest @Naomi_D_Harvey @tessfalor @ everyone!
Damn! It was THIS thread excellent by @tessfalor!! Sorry…!!

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More from @CiaraGlenville

Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
Jun 21
A unifying *hypothesis* to explain the seemingly miraculous response to #TheNicotineTest and how it might prevent PEM in #LongCovid #vaccineinjured #mecfs - a root cause approach to PEM by modulation of the Default Mode Network in the brain. Very long thread incoming!🧵
DMN is activated in the ‘off setting’ - meditation, day dreaming, no chores get done, no brain trigger to adapt to environment, may relate to feeling of being unable to talk/move/ respond in a crash. DMN is deactivated during activity, action, cognitive/ exercise Simple graph showing higher...
When measuring DMN, there is ‘activity’ and ‘connectivity’ to other brain parts. Both of these are altered in ME.
⬆️ connectivity at rest in ME with areas of fatigue and depression tinyurl.com/2u8chf7z
⬇️ connectivity / less coordinated during a task tinyurl.com/mseh93wy
Read 21 tweets
Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
Jun 16
Mitochondrial fission by Drp1: Imagine tying elastic band so tight around the mitochondria it breaks in half. As usual there’s a balance (recycling process) but excess fission linked to mitochondrial abnormalities in metabolic & neuro degenerative diseases… 🧵 #LongCovid #mecfs Image
Viruses *including HHV-6* can directly induce mitochondrial fragmentation through Drp1.
Steps to start? support the remaining mito to make enough energy & support mito biogenesis, inhibit Drp1, and tackle viruses to turn off the driving trigger (easier said than done)
ASHA-091 is a therapeutic designed to inhibit Drp-1. Not yet in clinical trials and anyone who’s been waiting for BC007 knows how that can go. Others include P110 peptide which I don’t think is in clinical trials yet. (H/T to @Nick_Wellings for this post)

ashatherapeutics.com/pipeline
Read 8 tweets
Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
Apr 27
The AXA1125 mimic I am taking: would like to help if others want to make it and can’t find info in sprawling tweets/ threads. Info here on how to make it, and a nice explainer video with reference to reduced lactate levels with AXA1125 too! 📣 #TheAcidTest
Original dosage from this paper: journals.lww.com/ajg/Fulltext/2…
And study in long Covid at 6 sachets per day in this: thelancet.com/journals/eclin…
Great explainer video here (with thanks to @Michaeltikus!). Note that also increasing blood volume is another mode of action I suspect
Read 6 tweets
Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
Apr 26
Finally got cancellation with my #LongCovid consultant. And it’s official, I have won the DOCTOR LOTTERY. He is just fantastic, get to him if you can 🇮🇪(Seamus Linnane, Beacon, Dublin). See thread for low blood volume hypothesis if it helps anyone, Dr agreed & we made a plan 🙌
Low O2 exchange in the lungs - low DLCO he says is quite possibly structural/ always been there. He had a hypothesis that this might be one predisposing factor in some LC cohort! I wonder could it be low blood volume, as one of the determinants is capillary blood volume?
Low blood volume and low blood pressure also likely predisposing in me. Always v low BP (90/60) and frequent urination/ high water loss, (HbA1c normal) AND looked at old FitBit data & my HR has always been erratic! I was fit though, running, weights, hiking, trail running..
Read 6 tweets
Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
Apr 26
#TheAcidTest 📣 Guide for at home lactate testing #pwME #LongCovid #vaccineinjured ! Please note your results, questionnaire to follow. If interested in US bulk buy/device sharing please DM @ales_frost
Please use #TheAcidTest if tweeting results. Join in! forms.gle/sDBr2BG8udKG4J…
UK device and *Ireland* device (this does ship to Ireland!) glucorx.co.uk/shop/glucorx-x…
Only £20 plus shipping. Added lactate strips currently free as due to expire on 24th May 23
frontiersin.org/articles/10.33…
Read 6 tweets
Ciara Wright PhD, Glenville Nutrition Ireland Profile picture
Apr 16
@remissionbiome / antibiotic update + new experiment connecting microclots - O2 delivery - lactate - mitochondrial repair - AXA1125 mimic. See🧵 for amounts to make mimic product ⬇️
⬆️ lactate producing bacteria in gut despite 4 mo of prep&repair which did improve leaky gut and dysbiosis. Wanted to reduce via antibiotics after herbal was insufficient. Did not have any remissionbiome style event but did not do same prep/ have all same products…
I did 5 days AmoxClav and saw no change. Switched to metronidazole for 7 days which I’d planned anyway on basis of microbiome results. No LC symptom change, digestion for a bit ropey with all this but feeling better now. Lactate monitor being delivered this week hopefully!
Read 10 tweets

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