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PolyBio Profile picture
@polybioRF
Feb 22 • 23 tweets • 6 min read • Read on X
We are excited to announce a 2nd series of collaborative projects & clinical trials supported via our LongCovid Research Consortium: polybio.org/new-longcovid-…
2/ The projects/trials further address #SARS-CoV-2 persistence in #LongCOVID, plus the impact of viral activity on #Alzheimer’s & cardiovascular disease. They include:
1. Icahn School of Medicine Mount Sinai: “A clinical trial of repurposed HIV antivirals in LongCOVID” 👉 Learn more here: polybio.org/projects/a-cli…
2. University of California San Francisco: “LIINC PASC Tissue Program: A multimodal assessment of the tissue-based virologic drivers of Long COVID” 👉 Learn more here: polybio.org/projects/liinc…
3. Yale University School of Medicine: “Molecular identification of SARS-CoV-2 RNA persistence” 👉 Learn more here: polybio.org/projects/molec…
4. French National Institute for Health & Medical Research/ESPOIRS: “SARS-CoV-2 persistence and impact on LongCOVID megakaryocytes & platelets” 👉 Learn more here: polybio.org/projects/sars-…
5. UMass Chan Medical School: “Impact of SARS-CoV-2 infection on Alzheimer’s and neurodegenerative disease” 👉 Learn more here: polybio.org/projects/impac…
6. New York University Grossman School of Medicine: “Deep characterization of SARS-CoV-2 cardiovascular reservoirs and plaque formation ” 👉 Learn more here: polybio.org/projects/deep-…
7. Karolinska Institutet Sweden: “Genetic variants and restrained antiviral immunity in severe LongCOVID” 👉 Learn more here: polybio.org/projects/genet…
8. University of California San Francisco: “COVID-19 Post Sudden Death Autopsy Study” 👉 Learn more here: polybio.org/projects/covid…
9. The J. Craig Venter Institute: “Deep characterization of antiviral immune responses & LongCOVID pathogenesis” 👉 Learn more here: polybio.org/projects/deep-…
10. Icahn School of Medicine at Mount Sinai: “LongCOVID & ME/CFS Lumbrokinase clinical trial” 👉 Learn more here: polybio.org/projects/lumbr…
11. University of Pennsylvania: “LongCOVID: Defining the viral RNA reservoir in the gastrointestinal tract” 👉 Learn more here: polybio.org/projects/long-…
12. The J. Craig Venter Institute: “LongCOVID oral cavity biomarker study” 👉 Learn more here: polybio.org/projects/long-…
13. Karolinska Institutet Sweden: “Impact of SARS-CoV-2 on LongCOVID gut & lymphoid pathology” 👉 Learn more here: polybio.org/projects/impac…
14. University of Pennsylvania: “Second phase expansion of LongCOVID T cell & lymph node analysis” 👉 Learn more here: polybio.org/projects/secon…
15. The J. Craig Venter Institute: “Mechanistic biomarker discovery of LongCOVID endotypes + Consortium LabKey data management” 👉 Learn more here: polybio.org/projects/mecha…
16. The OSLUV Project/Icahn School of Medicine at Mount Sinai: “LongCOVID clinic clean air initiative” 👉 Learn more here: polybio.org/projects/longc…
17. Icahn School of Medicine at Mount Sinai: “LongCOVID open medical education program” 👉 Learn more here: polybio.org/projects/open-…
A huge thank you to all our donors including @VitalikButerin for making the projects happen. Consortium teams are openly sharing ideas and samples across dozens of different academic institutions, laboratories, and clinics
@VitalikButerin @PutrinoLab @MBVanElzakker @MichaelPelusoMD @LocciLab @EJohnWherry @VirusesImmunity @marcus_buggert @BrodinPetter @drmfreire @elimtt
@VitalikButerin @PutrinoLab @MBVanElzakker @MichaelPelusoMD @LocciLab @EJohnWherry @VirusesImmunity @marcus_buggert @BrodinPetter @drmfreire @elimtt @PamBelluck @DrJudyStone @JDSteenhuysen @TheRobertHart @SarahNev @jechristensen @natashaloder @Jaime_Ducharme @ddiamond @ChrisCuomo @meghanor @DouthatNYT @sarahtoy17 @Brabbott42 @patmcgroarty @KatieMPalmer @matthewherper
@VitalikButerin @PutrinoLab @MBVanElzakker @MichaelPelusoMD @LocciLab @EJohnWherry @VirusesImmunity @marcus_buggert @BrodinPetter @drmfreire @elimtt @PamBelluck @DrJudyStone @JDSteenhuysen @TheRobertHart @SarahNev @jechristensen @natashaloder @ddiamond @ChrisCuomo @meghanor @DouthatNYT @sarahtoy17 @Brabbott42 @patmcgroarty @KatieMPalmer @matthewherper @JCVenterInst @MountSinaiNYC @HarvardHealth @YaleMed @UMassHealth @karolinskainst @UCSFHospitals @UCSFMedicine @MountSinaiRehab @IcahnMountSinai @PennMedicine @nyugrossman

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More from @polybioRF

PolyBio Profile picture
Jan 12
PolyBio is glad to have supported this Nature Immunology paper showing #LongCovid immune dysregulation connected to potential #SARS-CoV-2 tissue reservoirs. Learn more about the findings here: polybio.org/polybio-suppor…
2/ Overall, Long COVID patients showed differences in the distributions of their T cells, implying ongoing #immune responses. The team also documented a mis-coordination between the SARS-CoV-2-specific T and B cell responses of Long COVID patients.
3/ What underlies the T and B cell dysfunction identified in the study? Data point to the possibility that persistent #SARS-CoV-2 reservoirs in patient tissue are a contributing factor.
Read 9 tweets
PolyBio Profile picture
Nov 1, 2023
We are excited to announce a $15M gift from Kanro: a philanthropic fund to support scientific research established by Vitalik Buterin, co-founder of Ethereum: finance.yahoo.com/news/polybio-r…
2/ The funding will support a second phase of research and clinical trials via the #LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly and openly study core biological drivers of Long COVID: polybio.org/longcovid
3/ This is Buterin's second $15M gift to the Consortium and will allow dozens of new projects to move forward. The focus will be the continued study and treatment of #SARS-CoV-2 persistence as a driver of LongCovid.
Read 18 tweets
PolyBio Profile picture
Oct 21, 2023
We are excited to share that @MBVanElzakker & team at @MGHMartinos have published a preprint with the results of a high-resolution #LongCovid imaging study. They identified neuroinflammation across a wide range of brain regions in LongCovid patients: polybio.org/polybio-suppor…
2/ They additionally found that #neuroinflammation positively correlated with blood measures related to vascular dysfunction. The study is supported via our LongCovid Research Consortium Image
3/ More specifically, the team used a neuroimaging method called position emission tomography (PET) to measure #neuroimmune activation in the brains of LongCovid study participants
Read 14 tweets
PolyBio Profile picture
Aug 1, 2023
PolyBio is proud to have supported this new study by @MichaelPelusoMD & team. They identified tissue-based T cell activation in body sites such as brainstem/bone marrow + #SARS-CoV-2 RNA persistence in colorectal tissue up to 2 years post-COVID-19: medrxiv.org/content/10.110…
2/ More specifically they performed whole-body positron emission tomography (#PET) imaging in a group of 24 participants at time points ranging from 27-910 days following acute SARS-CoV-2 infection using a novel radiotracer that quantifies activated T lymphocytes
3/ Tracer uptake in the post-acute #COVID-19 group - which included participants with and without #LongCovid symptoms - was significantly higher compared to pre-pandemic controls in many anatomical regions Image
Read 11 tweets
PolyBio Profile picture
Apr 11, 2023
PolyBio is excited to be leading the LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly & comprehensively study #LongCovid disease mechanisms, with a focus on SARS-CoV-2 reservoir (). LCRC projects we are supporting include:polybio.org/longcovid
1. Perelman School of Medicine University of Pennsylvania: “Long COVID: Using #SARS-CoV-2 specific T cells as biosensors of viral persistence” 👉 Learn more here: polybio.org/projects/long-…
2. JCVI/Cardiff University/Karolinska Institutet: “Elucidation of SARS-CoV-2 reservoir and related Long COVID pathology in #lung tissue, fluid, and blood using molecular #virology & advanced sequencing” 👉 Learn more here: polybio.org/projects/eluci…
Read 22 tweets
PolyBio Profile picture
May 17, 2021
This is an important talk @resiapretorius gave at the @polybioRF Seminar Series. Her early pilot data (~10 subjects) shows that #LongCovid patients have abnormal microclots in their blood samples that are indicative of endothelial + platelet dysfunction:
2/ The microclots in the LongCovid samples contain serum amyloid A, fibrinogen, complement factors, and cytoskeletal kerratin. Dr. Pretorius has already filed a patent for diagnosing #LongCovid using detection of these deposits. She is also writing a paper on her findings.
3/ This is a cool image from her presentation that shows 1) the blood of a patient before #COVID-19 (healthy) 2) microclots in the patient’s #blood during COVID-19 3) microclots in the patient's blood several months later when they had #LongCovid symptoms
Read 5 tweets

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