Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2
❗Again, an interesting European review study with very clear take-aways👇
➡️"An infection with SARS-CoV-2 has the potential to manifest a diverse set of cardiovascular health problems, including myocardial tissue damage, arrhythmia, myocarditis, and pericarditis."
➡️"The main underlying pathophysiological mechanisms of morbidity and mortality are ongoing inflammation, with TNF-α and ILs as key mediators, oxidative stress, altered immune response, and subsequent apoptosis within cardiac tissue, alongside genomic changes."
➡️"Evaluation of existing comorbidities showed an increased chance of adverse infection outcomes in elderly, male, unvaccinated individuals, and such characterized by pre-existing cardiovascular complications, diabetes, and obesity."
➡️"Taken together, evidence is pointing toward prolonged COVID symptoms with cardiac involvement in some individuals, independent of infection severity, making it difficult to ascertain risk factors and biomarkers able to predict long COVID."
Take-aways:
1. Myocardial damage is a typical cardiac manifestation following SARS-CoV-2 infection.
2. Mechanisms include inflammation, oxidative stress, innate immune response, apoptosis.
3. Age, gender, pre-existing heart problems, comorbidities predict in-hospital mortality.
🤔Review has some noted limitations and I don’t fully agree with some conclusion points, but its clear that “cardiology” is waking up! #AboutTime #GoodNews
sciencedirect.com/science/articl…
❗Again, an interesting European review study with very clear take-aways👇
➡️"An infection with SARS-CoV-2 has the potential to manifest a diverse set of cardiovascular health problems, including myocardial tissue damage, arrhythmia, myocarditis, and pericarditis."
➡️"The main underlying pathophysiological mechanisms of morbidity and mortality are ongoing inflammation, with TNF-α and ILs as key mediators, oxidative stress, altered immune response, and subsequent apoptosis within cardiac tissue, alongside genomic changes."
➡️"Evaluation of existing comorbidities showed an increased chance of adverse infection outcomes in elderly, male, unvaccinated individuals, and such characterized by pre-existing cardiovascular complications, diabetes, and obesity."
➡️"Taken together, evidence is pointing toward prolonged COVID symptoms with cardiac involvement in some individuals, independent of infection severity, making it difficult to ascertain risk factors and biomarkers able to predict long COVID."
Take-aways:
1. Myocardial damage is a typical cardiac manifestation following SARS-CoV-2 infection.
2. Mechanisms include inflammation, oxidative stress, innate immune response, apoptosis.
3. Age, gender, pre-existing heart problems, comorbidities predict in-hospital mortality.
🤔Review has some noted limitations and I don’t fully agree with some conclusion points, but its clear that “cardiology” is waking up! #AboutTime #GoodNews
sciencedirect.com/science/articl…
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