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Al-Ola A Abdallah MD (USMIRC)

@Abdallah81MD

Jul 11 • 8 tweets • 4 min read • Read on X

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MGCS: Monoclonal Gammopathy of clinical significance #mmsm #myeloma #MedEd #MedTwitter 🧵 #USMIRC @USMIRCNEWS

Many differential diagnosis; mostly dependent on clinical diagnosis:
- Schintzler’s Syndrome
- Scleromyxedema
- TEMPI syndrome
- Cryoglobunemia
- NXG
- Clarkson disease

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

1) Schnitzler Sndrome

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

2) Scleromxedema

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

3) TEMPI syndrome

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

4) Cryoglobulinemia

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

5) NXG

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

6) Clarkson disease (SCLS)

#mmsm #myeloma #MedEd #MedTwitter #USMIRC @USMIRCNEWS

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More from @Abdallah81MD

Al-Ola A Abdallah MD (USMIRC)

@Abdallah81MD

Feb 1

1/Treatment of Myeloma:
- Transplant Eligible: (HR/SR)Dara/RVd
- Ineligible SR (DRd preferred)
Ineligible HR (VRd)
- Maintenance SR: lenalidomide
- Maintenance HR: VR (less evidence)
- 1st Relapse (HR/SR)Dara based therapy
- post triple RRMM: CAR-T then BCMA TCE then GPRC5D
#mmsm #myeloma #MedTwitter #MedEd #USMIRC @USMIRCNEWS @OncoAlert

2/Although 1q is considered as a High risk I still treat it as standard risk till I see more studies to show the impact of treatment on the outcomes!
- Regarding EMD (soft tissue) they are considered HR and treated within that group #mmsm #myeloma #MedTwitter #MedEd #USMIRC @USMIRCNEWS @OncoAlert

3/Transplant is still the standard of care for pts who are eligible! Even if they are in sCR after induction therapy
I don’t use consolidation therapy #mmsm #myeloma #MedTwitter #MedEd #USMIRC @USMIRCNEWS @OncoAlert

Read 4 tweets

Al-Ola A Abdallah MD (USMIRC)

@Abdallah81MD

Jun 24, 2023

Hematology and Medical Oncology conference/ Kansas: Updates from ASCO 2023 #mmsm #myeloma #MedTwitter #MedEd #USMIRC Relapse myeloma still a challenge! 3 classes (IMiDs, PI and CD38 MoA) played a role to improve survival & we are looking to see BCMA Directed therapy added

BCMA CAR-T based on 2 RCT showed improved PFS compared to SOC and that is enough for me to change SOC to either Ide-Cel/Cilta-Cel #mmsm #myeloma #MedTwitter #MedEd #USMIRC

TT2 targeting BCMA/GPRC5D might be the next level in triple/Penta RRMM with RR of 87-96%, PFS 21 months! Though we might have issues with AEs #mmsm #myeloma #MedTwitter #MedEd #USMIRC

Read 6 tweets

Al-Ola A Abdallah MD (USMIRC)

@Abdallah81MD

Jun 17, 2023

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, can also be found in reactive cells. imagebank.hematology.org/image/3230/fla… #mmsm #myeloma #MedTwitter #USMIRC #MedEd

Mott cell is a plasma cell characterized by an accumulation of multiple Russell bodies, globular cytoplasmic inclusions composed of immunoglobulin imagebank.hematology.org/image/61837/mo… #mmsm #myeloma #MedTwitter #MedEd #USMIRC

Russell bodies are cytoplasmic inclusions filled with immunoglobulins imagebank.hematology.org/image/4192/rus… #mmsm #myeloma #MedTwitter #MedEd #USMIRC

Read 7 tweets

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