(1/n)
Important discovery regarding the special thrombi (clots) observed by various embalmers and pathologists: staining with the sensitive amyloid dye Thioflavin T (ThT) is positive, i.e. they are probably amyloid-like thrombi!
Here are fluorescence microscopy images published by Richard Hirschman (@r_hirschman) and Greg (@Greg21143362):
Important discovery regarding the special thrombi (clots) observed by various embalmers and pathologists: staining with the sensitive amyloid dye Thioflavin T (ThT) is positive, i.e. they are probably amyloid-like thrombi!
Here are fluorescence microscopy images published by Richard Hirschman (@r_hirschman) and Greg (@Greg21143362):
(2/n)
(3/n)
(4/n)
(5/n)
(6/n)
The fact that these clots stain positive for ThT is not good news, as it indicates that these clots are special and cannot be easily dissolved by the body through fibrolysis.
Presumably, these clots are also full of neutrophil extracellular traps (NETs), as has already been shown for amyloid-fibrin microclots (which are probably the smaller form of these macroclots) [1]:
[1] researchsquare.com/article/rs-466…
The fact that these clots stain positive for ThT is not good news, as it indicates that these clots are special and cannot be easily dissolved by the body through fibrolysis.
Presumably, these clots are also full of neutrophil extracellular traps (NETs), as has already been shown for amyloid-fibrin microclots (which are probably the smaller form of these macroclots) [1]:
[1] researchsquare.com/article/rs-466…
(7/n)
Systematic studies are now needed to investigate these large clots using ThT-based fluorescence microscopy and, ideally, staining of NETs, as well as quantification of the amyloid fibrin microclot concentration (and size distribution) in plasma.
This would actually be a topic for a @Nature or @ScienceMagazine paper – which research group dares to tackle this hot and difficult topic?
For an earlier analysis of these clots, see my older post: x.com/DrJohnB2/statu…
Systematic studies are now needed to investigate these large clots using ThT-based fluorescence microscopy and, ideally, staining of NETs, as well as quantification of the amyloid fibrin microclot concentration (and size distribution) in plasma.
This would actually be a topic for a @Nature or @ScienceMagazine paper – which research group dares to tackle this hot and difficult topic?
For an earlier analysis of these clots, see my older post: x.com/DrJohnB2/statu…
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