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Akshay Sharma MD @akshaysharma.bsky.social Profile picture
Akshay Sharma MD @akshaysharma.bsky.social
@AkshaySharmaMD
Pediatric Bone Marrow Transplant @StJudeResearch #GeneTx #GenomeEditing #SickleCell Tweets and opinions are my own ≠ medical advice. COI: https://t.co/jfz4xGdu7N
Mar 16, 2023 • 6 tweets • 4 min read
In our latest publication in @BloodJournal, @pigtowner and I report an increase in myocardial extracellular volume (ECV) in patients with #SickleCell disease despite early intervention with disease-modifying therapies ☹️ sciencedirect.com/science/articl… Increased ECV fraction correlates strongly with histologically quantified myocardial fibrosis👉leading to cardiomyopathy (which is a leading cause of death in individuals with #SickleCell disease).
Feb 8, 2021 • 5 tweets • 5 min read
#TCTM21 Significantly worse EFS and higher incidence of graft failure among #SickleCell disease patients undergoing #BMTsm on Medicaid compared to private insurance - Very important study from @CIBMTR by Tatenda Geraldine Mupfudze and colleagues tct.confex.com/tct/2021/meeti… Similar trend in #BMTsm utilization in adult acute leukemia patients’ - public insurance, race and older age has significant influence on #HCT utilization, abstract by Silas Day #TCTM21 tct.confex.com/tct/2021/meeti…
Jan 20, 2021 • 19 tweets • 17 min read
What happens to hematopoietic transplant recipients who develop #COVID19?

Transplant recipients and transplanters have been asking this question ever since the pandemic began.

Our analysis using @CIBMTR data is out today in @TheLancetHaem thelancet.com/journals/lanha…. 1/ While there have been close to 100,000 papers related to COVID-19 listed on @NCBI @NLM_NIH #Pubmed, there are very few that address outcomes after #COVID19 in #BMTsm patients, a few are listed in the next tweet: 2/