Pediatric Bone Marrow Transplant @StJudeResearch #GeneTx #GenomeEditing #SickleCell Tweets and opinions are my own ≠ medical advice. COI: https://t.co/jfz4xGdu7N
Aug 2 • 6 tweets • 2 min read
Last year we published in @BloodJournal that diffuse myocardial fibrosis was very common in individuals with sickle cell disease and that hydroxyurea and blood transfusions did not prevent it, even if these were started at a young age. ashpublications.org/blood/article/…
This was a very disappointing finding - as diffuse myocardial fibrosis could be associated with several heart problems and heart failure in individuals with sickle cell disease... We wondered if a bone marrow transplant would be any good? #SCD #BMTsm
Mar 16, 2023 • 6 tweets • 4 min read
In our latest publication in @BloodJournal, @pigtowner and I report an increase in myocardial extracellular volume (ECV) in patients with #SickleCell disease despite early intervention with disease-modifying therapies ☹️ sciencedirect.com/science/articl…
Increased ECV fraction correlates strongly with histologically quantified myocardial fibrosis👉leading to cardiomyopathy (which is a leading cause of death in individuals with #SickleCell disease).
Feb 8, 2021 • 5 tweets • 5 min read
#TCTM21 Significantly worse EFS and higher incidence of graft failure among #SickleCell disease patients undergoing #BMTsm on Medicaid compared to private insurance - Very important study from @CIBMTR by Tatenda Geraldine Mupfudze and colleagues tct.confex.com/tct/2021/meeti…
Similar trend in #BMTsm utilization in adult acute leukemia patients’ - public insurance, race and older age has significant influence on #HCT utilization, abstract by Silas Day #TCTM21tct.confex.com/tct/2021/meeti…
Jan 20, 2021 • 19 tweets • 17 min read
What happens to hematopoietic transplant recipients who develop #COVID19?
Transplant recipients and transplanters have been asking this question ever since the pandemic began.
