I wanted to share one more figure from the #Omicron pre-print that I think offers some additional support for the idea that mRNA boosting doesn't just increase the total neutralizing response but instead "broadens" it to enable Omicron neuralization: What these graphs show is a comparison of neutralization activity against the original strain (wild type) on the X axis and either Delta or Omicron on the Y axis. White dots represent samples from recently vaccinated, black squares from recently boosted individuals.

Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to @wilfredo_nk, @kstdenis29, @EvanCLam, @adamnitido, @NaranbhaiVivek who have been up at all hours of the night both at the bench and writing the paper!

1/16 We generated harmless pseudoviruses decorated with spikes that represent circulating Delta and Omicron spike proteins. Compared to the Wuhan isolate, Delta has 9 mutations in spike, but Omicron has 34!

2/16

Our paper describing the potential for mRNA vaccines to induce antibodies capable of neutralizing many of the circulating variants is now available online at Cell!
cell.com/cell/fulltext/… We created pseudoviruses representing many of the globally circulating variants, many containing numerous mutations in and around the receptor binding domain (RBD)

As we wait for medRxiv, I wanted to share our complete results in a new thread. I want to stress that this is still a pre-print that has not yet undergone peer review. Many thanks again to @wilfredo_nk @EvanCLam @kstdenis29 and @NaranbhaiVivek for all of their hard work! To test the potential for both the Pfizer and Moderna vaccines to produce serum responses capable of neutralizing circulating #SARSCoV2 variants, we built a series of spike-expression plasmids:

We have just uploaded a pre-print to MedRxiv sharing our data on the potential for sera from recipients of currently administered mRNA vaccines to neutralize 10 different circulating strains of #SARSCoV2. Before it posts online, I'd like to put them into context. A thread:
1/12 Here's a key graph from our pre-print showing the results of our neutralization assay on sera taken from vaccinees receiving two or one dose of BNT162b2.
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