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Charles Swanton Profile picture
Charles Swanton
@CharlesSwanton
Cancer Evolution and Genome Instability, Lung Oncologist Air Pollution and Drug Resistance Fair Weather 🚴
Jan 13 • 5 tweets • 2 min read
Our paper describing the use of an ultrasensitive circulating tumour DNA detection assay to stratify #TRACERx patients with early-stage non-small cell lung cancer pre-operatively for clinical outcome is out today @NatureMedicine. Thread below 👇 Image ctDNA is an established biomarker for high-risk disease before and after surgical resection in NSCLC. We tested NeXT Personal, an assay from @PersonalisInc able to detect ctDNA at extremely low levels, to understand whether ultra-sensitive approaches provide added value here.
Apr 13, 2023 • 22 tweets • 13 min read
Excited to share our TRACERx nature publication on circulating tumor DNA (#ctDNA, #MRD) detection in resectable lung cancer led by @AbboshChris, @AFrankell, @juditkisistok, Thomas Harrison, Aaron Garnett, @nbirkbak and @NickyMcGranahan 👇👇👇 Tweetorial🧵

nature.com/articles/s4158… 🔬Circulating tumor DNA is a powerful biomarker that can guide and monitor treatment response in early-stage lung cancer patients. Technologies enabling ctDNA detection and characterization are advancing rapidly but we need to understand how to use them in the clinic…
Apr 12, 2023 • 13 tweets • 10 min read
Excited to share our recent @SwantonLab @NickyMcGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out @Nature

nature.com/articles/s4158…

A quick thread [1/13] We analysed paired primary-metastasis data from 126 patients (218 metastatic & 476 primary tumour samples) within the first 421 patients recruited to TRACERx. We explored the timing of metastatic divergence, modes of metastatic dissemination and selection in seeding clones [2/13]
Apr 5, 2023 • 16 tweets • 12 min read
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵nature.com/articles/s4158… Image Air pollution is linked with 7 million premature deaths annually and is associated with heart disease, cancer and dementia. The vast majority of people live in places where air pollution levels exceed @WHO guidelines Image
Sep 2, 2020 • 24 tweets • 11 min read
1/24 - Can we decipher order from cancer genomes? Our new paper “Pervasive chromosomal instability and karyotype order in tumour evolution” comes out in Nature today: nature.com/articles/s4158… @BCRFcure @TheCrick @CRUKresearch @RosetreesT @uclcancer @SwantonLab @royalsociety 2/24 - Chromosomal instability (CIN) is common in cancer and consists of dynamic changes in chromosome number and structure. This instability can result in somatic copy number alterations - SCNAs - which may provide a substrate for tumour evolution.