Charles Swanton Profile picture
Francis Crick Institute and University College London Hospitals
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Apr 13, 2023 22 tweets 13 min read
Excited to share our TRACERx nature publication on circulating tumor DNA (#ctDNA, #MRD) detection in resectable lung cancer led by @AbboshChris, @AFrankell, @juditkisistok, Thomas Harrison, Aaron Garnett, @nbirkbak and @NickyMcGranahan 👇👇👇 Tweetorial🧵… 🔬Circulating tumor DNA is a powerful biomarker that can guide and monitor treatment response in early-stage lung cancer patients. Technologies enabling ctDNA detection and characterization are advancing rapidly but we need to understand how to use them in the clinic…
Apr 12, 2023 13 tweets 10 min read
Excited to share our recent @SwantonLab @NickyMcGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out @Nature…

A quick thread [1/13] We analysed paired primary-metastasis data from 126 patients (218 metastatic & 476 primary tumour samples) within the first 421 patients recruited to TRACERx. We explored the timing of metastatic divergence, modes of metastatic dissemination and selection in seeding clones [2/13]
Apr 5, 2023 16 tweets 12 min read
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵… Image Air pollution is linked with 7 million premature deaths annually and is associated with heart disease, cancer and dementia. The vast majority of people live in places where air pollution levels exceed @WHO guidelines Image
Sep 2, 2020 24 tweets 11 min read
1/24 - Can we decipher order from cancer genomes? Our new paper “Pervasive chromosomal instability and karyotype order in tumour evolution” comes out in Nature today:… @BCRFcure @TheCrick @CRUKresearch @RosetreesT @uclcancer @SwantonLab @royalsociety 2/24 - Chromosomal instability (CIN) is common in cancer and consists of dynamic changes in chromosome number and structure. This instability can result in somatic copy number alterations - SCNAs - which may provide a substrate for tumour evolution.