Reflecting on today's fantastic #iMED2022, I am thrilled to share an app I've been creating to create high-quality🤓, collaborative🗺️, & dynamic 📈diagnostic #MedEd schemas!

Schematify App Here: diagnostic-schema.herokuapp.com
Video:
Check it out: 1/ Medical learning is all about the organization of a HUGE amount of (growing) knowledge😅

I loved the concept of a logical framework...but my handwriting, spelling and ability to hold onto paper documents is👎🙈

Plus, I wanted to be able to collaborate dynamically with YOU!🤩 2/

Ever wonder what the #3Dgenome folding🔺of a Neanderthal looked like?! Could it hold any clues as to where and why we have DNA 🧬and trait differences?

Check out our @capra_lab, Pollard lab & @gfudenberg lab collaboration @biorxivpreprint biorxiv.org/content/10.110…

1/8 Sadly, bc of ancient👴sample degradation, we've never explored the role of the 3D genome in archaic hominins like Neanderthals/Denisovans.

But lucky for us, new deep learning models can infer 3D genome structure from DNA sequence alone (like @gfudenberg & @drklly's Akita).

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As promised, here is my #tweetorial for our @capra_lab @NatureComms paper! Interested in complex trait #genetics, #heritability, #Evolution , or #Neanderthals ? 🧬

Paper: nature.com/articles/s4146…
"Behind the paper" article: natureecoevocommunity.nature.com/posts/uncoveri…

1/ We have examples of how Neanderthals gave Eurasians individual genetic variants that contribute to traits; however, most medically/evolutionarily relevant traits are complex, with contributions from thousands of parts of the genome. We wanted something more comprehensive...

2/

Excited to present my first @capra_lab PhD project in today's @GeneticsSociety's @AJHGNews!!

Interested in #3Dgenome structure, complex trait #heritability, and/or evolutionary constraint?

cell.com/ajhg/fulltext/…

1/n By synthesizing topologically associating domain (TAD) maps across 37 diverse cell types with 41 genome-wide association studies (GWASs), we investigate the differences in disease association and evolutionary pressure on variation across the 3D genome landscape.

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