There are a number of issues to consider: a) your point about needlessly medicalising obesity is relevant if we stick to the >BMI 30 metric. If, however, we consider to be carrying too much fat, that it is influencing your health, then obesity, by definition, is a disease 1/n

https://twitter.com/mlkytee/status/1793644850774216751

b) which leads to the follow up question of how much fat is too much? That depends. e.g. We know that South Asians (Indians, Pakistanis) and East Asians (folk that look like me) can't carry too much fat, before increasing our risk of disease, compared to white people 2/n

As requested by @TamarHaspel here is a brief tweetorial on my latest @NatureRevGenet review on the #genetics 🧬 of #obesity rdcu.be/cyjVV 🧵👇 1/7

https://twitter.com/GilesYeo/status/1441085877539663891

While changes in the environment have driven its increased prevalence, obesity results from interaction between environmental & biological factors. Crucially, there is a strong genetic component underlying the large variation in body-weight in today’s ‘obesogenic’ environment 2/7