DoxyPEP implications for antimicrobial resistance next. Methods of development of tetracycline resistance are effluent pumps, enzymatic inactivation, ribosomal protection, or single mutation in 16s rRNA. Most commonly it is the tet gene, esp in NG Just fyi, Chlamydia trachomatis and Treponema pallidum are not inherently resistant to tetracycline. However Chlamydia suis in pigs can be resistant, and can transmit its method of resistance to CT. Brachyspira hyodysenteria in pics can also be resistant and transmit to TP

Updates on HIV and STI prevention!! So excited!! First up, Phase 1 annual TAF implants in cisgender women - CAPRISA Trial #CROI2024
Group 1 - 1 implant, Group 2- 1 or 2 implants (up to 48 weeks)
No serious adverse events
Induration, hyperpigmentation, and tenderness most common 11 (31%) early removals in the study, with 2 having had an abscess
Plasma TAF concentration detected in 77% of samples
There was poor tolerability overall though with lower than planned drug release. Gonna need higher drug release and lower site reactions

SUPER excited for this panel this AM! Stay tuned for updates on Doxy PEP!! #STDConf22 Amazing results with Doxy PEP, 65% reduction in STIs per quarter, 55-57% reduction in GC, 74-88% reduction in CT, and 87% reduction in syphilis (only significant among PrEP but not much baseline syphilis)

#AIDS2022 Plenary Session on HIV in Indigenous Cultures in Canada
Stigma amongst Indigenous peoples with HIV still prominent, especially in rural areas still play a role, secondary to imposed ideology of Church and colonization
This is a major barrier to reaching 95-95-95 goals A call for Indigenous People to be included as a Priority Population in the global HIV response, with global commitment to these peoples all around the world, wherever Indigenous People happen to be. #AIDS2022

Good morning from Day 2 from #AIDS2022, first talk, the possibility of HIV mRNA Vaccine
Difficulties - HIV integrates into DNA, highly mutable, and complex response to HIV envelope glycoprotein An mRNA vaccine was able to create broadly neutralizing antibodies however much different landscape on surface of HIV compared to SARS-COV-2
mRNA sticks around, is cheap to produce, easily modified, and creates endogenous protein
Of course vaccine equity is v important #AIDS2022

Newly released WHO Consolidated Guidelines on HIV, Hepatitis, and STI prevention, diagnosis, treatment, and care for key populations

who.int/news/item/29-0…

#AIDS2022 Essential health interventions recommended below!

It’s starting!!! Updates to come after the presentation but updates to the CDC STI Guidelines @CDCSTD #IDtwitter The current state of Gonorrhea, Chlamydia, primary and secondary Syphilis, Congenital Syphilis, and the effect of COVID-19 on STI testing