Josh Tycko Profile picture
I research chromatin regulation & epigenome engineering Postdoc at Harvard Med, Greenberg lab & BIDMC, Pollak lab
Sep 11, 2020 13 tweets 9 min read
Please enjoy our new #preprint, "High-throughput discovery and characterization of human transcriptional effectors"! 😀

We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110… For many human #TranscriptionFactors & #chromatin regulators, we know more about *where* they bind than *how* they regulate expression

To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit Image