Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Josh Tycko Profile picture
Josh Tycko
@JoshTycko
Postdoc at Harvard Med, Greenberg lab & BIDMC, Pollak lab aka DJ Fishing Expedition
Sep 11, 2020 • 13 tweets • 9 min read
Please enjoy our new #preprint, "High-throughput discovery and characterization of human transcriptional effectors"! 😀

We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110… For many human #TranscriptionFactors & #chromatin regulators, we know more about *where* they bind than *how* they regulate expression

To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit Image