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Niek Verweij Profile picture
Niek Verweij
@Niek_verweij
This is my wall of stickies. Genetic Epidemiology. Translational genetics cvd @regeneron.
Aug 3, 2022 • 11 tweets • 11 min read
Our discovery of mutations in the CIDEB gene that protect against liver disease is published in @NEJM, leading to possible #RNAi therapeutics for NASH by Regeneron & Alnylam. 🚨
nejm.org/doi/full/10.10…

A short summary of the key findings 🧬🧵↓ ImageImage Liver disease is a big unsolved problem:

1⃣ 1 in 3 adults globally have fatty liver, often due to #obesity.

2⃣ Liver inflammation due to fat (NASH) is becoming #1 cause of liver transplant.

3⃣No approved therapies.

Where can we find possible NASH targets?

➡️In our DNA! Image