🚨 New preprint with @KasperJanssen alert! 🚨
1/ Patients with Long COVID often struggle with fatigue, autonomic dysfunction, and post-exertional malaise (PEM). Can wearable heart rate variability (HRV) monitoring help? Our latest study suggests YES. 1/xmedrxiv.org/cgi/content/sh… @KasperJanssen 2/ MSc student Twan Ruijgt, together with @KasperJanssen, tracked 127 Long COVID patients and 21 healthy controls using continuous HRV monitoring over multiple days. Participants also underwent submaximal (!) exercise testing to determine individual ventilatory thresholds. 🏃‍♂️📊

📢 Long COVID symptoms include fatigue, brain fog, myalgia, and post-exertional malaise (#PEM). This thread dives into our newest literature review exploring skeletal muscle dysfunction as a key factor in reduced exercise capacity for #LongCovid . 🧵cell.com/trends/endocri… With @BraedenCharlton, @RichieGoulding1, @JaspersLab, we performed a literature review and found that LC patients show reduced aerobic capacity, earlier lactate buildup, and muscle abnormalities. Mitochondrial dysfunction and endothelial issues are major contributors to fatigue.

Delighted to see our latest work on "The impact of bed rest on human skeletal muscle metabolism“ out in @cellrepmed! Thanks to @DLR_en , @esa, @nasa, @m_eggelbusch @BraedenCharlton and all colleagues for the collaborative effort! doi.org/10.1016/j.xcrm… Our results of >4 years of measurements on human skeletal muscle biopsies and blood samples highlight that bed rest leads to a rapid intracellular glycogen and lipid buildup, accompanied by a decrease in insulin insensitivity after only 6 days of bed rest.

After a long wait, our longitudinal long COVID study is finally published in @NatureComms: . We find a skeletal muscle alterations in patients with #longcovid, which worsen with exercise. 1/nnature.com/articles/s4146… With @BraedenCharlton, and clinical colleagues (Brent Appelman and Michele van Vugt), we confirmed the lower exercise capacity in patients with #longcovid, which can partly be explained by changes in skeletal muscle structure and function 2/n

Voor onze #longcovid studie met het @amsterdamumc zoeken we nog een aantal gezonde mensen die wel het covid-virus opgelopen hebben, maar geen langetermijnklachten hebben. Er worden bloed en 2 rijstkorrels spier afgenomen om te onderzoeken wat de veranderingen zijn ... 1/n .... in het spierweefsel van mensen met #LongCovid, en waarom patienten ziek worden van bewegen #PEM. Iedereen (die verder gezond is), tussen de 25 en 65 jaar kan meedoen. Stuur me een PB met emailadres en telefoonnummer zodat ik de proefpersonen informatie kan doorsturen.2/n