Ed Profile picture
Ed
Professor, Author & Researcher - Internal Medicine, Infectious Diseases & Clinical Pharmacology
Jun 25, 2022 6 tweets 1 min read
Atopic dermatitis:

The main issue here is dryness for PROLONGED periods.

Dryness
=
Eczema What non-phrmaoclogic options do work?
- Aerobic exercise
- Smoking cessation
- Sugar deficient food

What’s common between all three?
LESS oxidative stress from cells

Do oils baths work?
Maybe!

Does regular sex help?
Yes! Poorly regulated sex hormones exacerbate eczema!
Jun 17, 2022 7 tweets 3 min read
If you’re an IMG who studied medicine in English and passed all #USMLE steps, you should NOT be required to sit for an English language exam.

Enough with the ripoff and making money out of the poor students. If you’re an IMG (or US graduate) who passed all #USMLE steps and interested in primary care in rural areas (where there is DIRE need for primary care physicians), you should be offered contracts with competitive salaries.
May 18, 2022 8 tweets 3 min read
Pay attention to this thread:

Sodium/Glucose Cotransporter *2* (SGLT2) receptors are in the *1st* part of the proximal tubule, where 90% of glucose reabsorption occurs & also where SGLT2 inhibitors like empagliflozin work.

SGLT *1* receptors are in the *2nd* part of the tubule. Image SGLT2i ↓ systolic HF mortality in patients with OR without diabetes.

Drugs that ↓ systolic HF mortality:
•ß-blockers (metoprolol, bisoprolol, carvedilol)
•ACEi
•ARBs
•MRAs
•Hydralazine (with nitrates)
•Neprelysin inhibitor (sacubitril)
•SGLT2 inhibitors Image
Oct 20, 2021 6 tweets 1 min read
The FDA committed an act of STUPIDITY today.

Correction: an act of social injustice!

Thread/ Earlier today, the FDA approved two drugs that have been available generically for years (celecoxib and tramadol), by allowing the pharmaceutical mafia to combine them into a single pill, and market as a NEW medication to treat acute pain!

drugs.com/newdrugs/fda-a…
Aug 21, 2021 21 tweets 4 min read
Here is a thread for those of you who don’t know the history - just so you get an idea of how bleak the situation in #Afghanistan really is. And it’s not only about the US citizens over there, it’s about an ENTIRE nation and it’s people.

1/n
In 1996, after a long, brutal war against the Western Allies that saw thousands of nmicent civilians (mostly children) die, the Taliban gained power in #Afghanistan. Once in control, they issued & broadcasted SIXTEEN decrees on “Islamic Sharia Radio”

The read as follows:

2/n
Dec 5, 2020 27 tweets 10 min read
Part of the reason behind the skepticism of nearly 50% of Americans in regard to the #coronavirus vaccine is related to what they perceive as “hastened” or “political” approach to emergency use authorization. But what most don’t realize, the vaccine saga began over 250 years ago! In colonial America, “doctors” did not study medicine at school. Instead, they trained through an “observership” with a local practitioner (typically from Europe). In fact, the earliest medical schools in colonial America didn’t start awarding medical degrees until decades later.
Dec 2, 2020 12 tweets 3 min read
FYI: Even with a #coronavirus vaccine, this pandemic will get WORSE in the next few months & more people will die. It’s how pandemics work.

In about a year from now, there’ll be ANOTHER wave of coronavirus infections. Hopefully the vaccine will lessen its impact. The presence of a vaccine against a disease is NOT synonymous with disappearance of the disease.

The basic public health measures like physical distancing, masks especially indoors, and personal hygiene are invaluable in curbing the transmission of infections.
Mar 12, 2020 12 tweets 3 min read
Here are a few ideas and thoughts I put together as a pharmacologist on possible theoretic interventions and theoretical mechanisms of action of drugs against #Covid_19.

Thread. Coronavirus virus particles contain FOUR main structural proteins. These are the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins. Targeting any of these proteins with drugs will be a potential pharmacological intervention.