Breaking News @AHAScience with #TRANSFORMHF - the largest (N=2859) ambulatory #heartfailure diuretic trial to determine if torsemide would be superior to furosemide to ⬇️ reduce all-cause mortality - what a huge accomplishment of @robmentz et al!!! (1/9) sciencedirect.com/science/articl…
At first sight 'no need to transform your practice' as both are similarly effective for mortality (2/9)
Oct 11, 2022 • 10 tweets • 6 min read
Tweetorial on #vasodilators for low-output #heartfailure
to improve hemodynamics which help to decongest better and allow introduction/uptitration of neurohumorel blockers.
(as addendum to
Do you ever wonder what is happening in the kidney in Heart Failure patients? Here’s a short #Tweetorial on renal physiology in HF (1/6). #Cardiotwitter#Cardiology#FOAMed#Cardiorenal#MedEd#MedTwitter#Nephrology#ADVOR
Glomerulus: renal blood flow ↓ in HF, but the kidney tries to maintain GFR by afferent arteriolar vasodilation and efferent arteriolar vasoconstriction. This leads to single-nephron hyperfiltration initially preserving total GFR, but further damaging the glomerulus. (2/6)