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@AbrahamLabHMS Profile picture
@AbrahamLabHMS
@abrahamlabhms
Visualizing emerging viruses using tools in structural biology.
Feb 16, 2022 • 4 tweets • 3 min read
For those wondering how the newest kid on the block, LY-CoV1404 (bebtelovimab) neutralizes variants so well, including #SARSCoV2 #Omicron BA.1.1 and BA.2? The answer is – pure luck! This antibody is like Neo dodging bullets in the matrix…🍀🍀🍀 The binding mode is very similar to imdevimab (REGN10987) but bebtelovimab avoids major imdevimab resistance caused by the N440K Omicron mutation! It also avoids other mutations. Think social distancing of antibodies from mutations...
Dec 2, 2021 • 8 tweets • 4 min read
Excited to share our manuscript just published @ScienceMagazine describing mechanisms for continued antibody evasion of the SARS-CoV-2 RBD. Hopefully, the findings help us better prepare for #Omicron.
science.org/doi/10.1126/sc… Most prior studies examined RBD escape mutations in isolation or in small numbers, but we studied variants that contain many simultaneous spike protein mutations (e.g., RBD mutations at K417, T478, E484, Y489, Q493, S494, and N501, and NTD deletions).