1/9 🚨 A shingles vaccine may be doing something nobody expected: slowing dementia.

Not a lab study.
Not a survey.
A “natural experiment” with 300,000+ real people — where birthdays decided who got offered the shot. 2/9 🗣️ Here’s the wild part:

In Wales, the NHS rolled out the (live) shingles vaccine using a strict date-of-birth cutoff.

Turned 80 just AFTER the start date? Eligible for 1 year.
Turned 80 just BEFORE? Ineligible… for life.

SkepDoc's Corner: Deuterium Depleted Water

By @HHSkepDoc

skepticalinquirer.org/exclusive/deut… Sample of recent publication (which promoted my lit search and identifying Harriet's blog post👆 -@agingdoc1):

Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice

mdpi.com/1467-3045/45/1… (@CIMB_MDPI)

I asked chat-GPT to help me write a tweet thread on how it can help accelerate progress in geroscience. Here’s what she came up with… 👇

/1 "Exciting news! #ChatGPT is being used to accelerate progress in the field of #geroscience. The ability to understand and generate human-like text allows for efficient data analysis and novel research opportunities. #AI #HealthTech

/2

Rapamycin dosing hypothesis:

This is just a hypothesis, needs testing: Severe mTORC2 inhibition is harmful (esp in males), but mild inhibition is ~neutral or possibly mildly beneficial in some settings (eg-cancer). This is a thread, keep clicking on msg to keep reading.... Advise 1st read in full includ. intro & discus. re: mTORC2 inhibition concerns (1) ncbi.nlm.nih.gov/pmc/articles/P… & (2) onlinelibrary.wiley.com/doi/full/10.11… (3) pubmed.ncbi.nlm.nih.gov/31577953/ (4) pubmed.ncbi.nlm.nih.gov/31373126/ (5) pubmed.ncbi.nlm.nih.gov/32720643/ (6) pubmed.ncbi.nlm.nih.gov/30794726/
@LammingLab & other great work

@Blagosklonny The following is for educational purposes only, and not medical advice.
@Blagosklonny is a pioneer in rapamycin research & was the first to propose it has the potential to extend life based on its mechanism of action (keep reading, this discussion & calculations are stacked)..🧑‍🔬 @Blagosklonny his prediction was subsequently confirmed in Saccharomyces (yeast), C elegans (nematode worms), Drosophila (fruit flies), mice, and others.
Rapamycin (sirolimus) has been used off-label for theorized healthspan and/or lifespan by such celebrities as @PeterAttiaMD...(keep reading)

Science is tricky: “Of the four main signaling pathways implied to be linked to the impact of CR on lifespan ([IIS, NF-ĸB, mTOR & sirtuins])...the pathways except SIRT were altered in a manner consistent with increased lifespan.” (Cont.).... ncbi.nlm.nih.gov/pmc/articles/P… ...so to what extent does this reflect 1) role of sirtuins in CR (2)(-) extrapolation from C57BL/6 mice 3) assay sensitivity 4) experiment conditions 5) network complexity 6) “other”. This was a great study & trends>individual studies. Every💪 study ➡️ ⬆️ Q’s than A’s, to explore

“The aging organism may also be viewed as a system with chemical fluctuations caused by biological reactions in the organism. This notion takes the whole organism as collected microscopically ordered patterns resembling oscillating chemical reactions.”

5 👍for correct author ID! “In such reactions, the chemicals involved form a dissipative structure far from the equilibrium, which allowed the raw materials to be transformed to maintain as a certain self‐assembled biological structure that is ordered both spatially and temporally.....

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21 -

This relates to a recent themes & trends in the tweet-verse
onlinelibrary.wiley.com/doi/full/10.11… “Our findings suggest that MR feeding can reverse the negative effects of aging on body mass, adiposity, and insulin resistance through an FGF21 mechanism. These findings implicate MR dietary intervention as a viable therapy for age‐induced metabolic syndrome in adult humans.”

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

An “oldie” (2017) but goodie- H2S is not only emerging as a DR-mimetic modulator, but also characterizes one Ho why GHR-KO fair better than other classic genetic LE models. ncbi.nlm.nih.gov/pmc/articles/P… “Reduced thyroid hormone (TH) and growth hormone (GH) activity are hallmarks of genetic models of longevity in mice. [...]TH and GH negatively regulate hepatic production of the longevity-associated gas H2S, which feeds back to negatively regulate circulating TH and IGF-1 levels”

TMAO (in seafood) reduces mortality in heart failure rats:
A hypothesis paper- to be treated with caution, but worth following. It throws a wrench in the TMAO (already part of Cleveland Clinic❤️labs) as risk factor epidemiology/ theory. Science is agnostic elifesciences.org/articles/57028 This link has a button to listen to the quick-interview by @NakedScientists

thenakedscientists.com/articles/inter…

The first official #agingdoc1 poll. Background: I serve, in order (1) Researchers (2) MDs/DOs & other providers (3) Investors (4) Top >1% of health-educated non-professional public. Each w/ their own unique interest & educational level (tricky!). How am I doing? For YOUR purpose: Previous feedback has led to fewer abbreviations (keeping them densely for scientist-geared material, but substantially cut back the rest),⬆️disambiguation & ⬆️explanations & discussion of sources.

What else would you suggest? Please comment below, I take all feedback seriously

Big announcement in Geroscience!
Deep Longevity (DL) has been acquired by a publicly-traded company called Regent Pacific. Alex Z.@biogerontology has stepped down as DL CEO & will assume a new role of a Chief Longevity Officer (CLO) at the company(1/2)

medium.com/@longevity/the… Jim Mellon will serve chairman, Dr. Wei-Wu He will join as director. The announcement was made as DL-agingpharma.org is underway w/ 1000s viewing live and dozens of talks. They are building a global biomarker-driven longevity biotechnology ecosystem w/ deep aging clocks.

@IFdiet Short interview of Mattson PhD geared towards clinicians & very lucid: podcasts.jwatch.org/index.php/podc…

It reflects increasing appreciation by MDs of the potential of therapeutic fasting (@PeterAttiaMD @drjasonfung).
Figure 4 offers a sample fasting Rx: gwern.net/docs/longevity… I would be remiss not to mention CR pioneer Luigi Fontana MD @LuigiFontana22 among the ranks of clinician-champion of fasting as Rx.

truenorthhealthfoundation.org has been bolstered by translational research, which also supports standardized options: Eg-Valter Longo PhD's @prolonfmd