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Andreas Horn Profile picture
Andreas Horn
@andreashorn_
Former account – Now at @andreashorn.org on bluesky. https://t.co/pohTcnIvXN
Dec 22, 2023 • 20 tweets • 8 min read
To treat OCD, Deep Brain Stimulation to the ventral capsule is effective – but the optimal target site remains unclear.

In a huge collaborative effort @garance_meyer & @c_neudorfer set out to determine it @BiologicalPsyc1. A 🧵 👇👇

researchgate.net/publication/37…
Image First, a lot of fantastic colleagues contributed data for this analysis, resulting in a total of 176 DBS sites from 8 international centers analyzed! @DrPhilipMosley @HarithAkram @DarinDougherty @Martijn_Figee_ @HelenMaybergMD @SameerShethMD @VVV_Cologne @BaldermannJC et al. 🙏 Image
Sep 9, 2022 • 23 tweets • 13 min read
Thrilled to share our work on DBS for #Alzheimer’s Disease

– likely the most important work in my career, so far.

Spearheaded by the one and only @sofiari91 w/ lots of collaborators, we sought out to find the optimal DBS stim site & network in AD

medrxiv.org/cgi/content/sh…

A 🧵 Image First, it is impossible to tag everyone that collaborated on this massive effort & it was a great honor to work on the data from the multicenter ADvance trial since ~2018 to make this possible. Big thanks to the Toronto team & Andres Lozano – and of course to all patients! 🙏 Image
Oct 7, 2021 • 14 tweets • 7 min read
Very excited about this new work by @c_neudorfer et al. since we believe it could actually change clinical practice for thalamic DBS for tremor.

How? Read on.

w/ @daniel_krnbrg, @Bassam_Al_Fatly, @LLGoede, @ToddMHerrington, @EMiddlebrooksMD, @AA_Kuhn

researchgate.net/publication/35… Advanced imaging sequences allow us to directly visualize anatomical targets for deep brain stimulation and account for interindividual neuroanatomical variability. This could be especially beneficial obscure targets such as the ventral intermediate (Vim) thalamic nucleus.
Aug 2, 2021 • 10 tweets • 6 min read
New #preprint out on mapping effects of DBS for cervical vs. generalized dystonia to the connectome. A brief thread.

researchgate.net/publication/35… Based on N = 80 patients from five DBS centers, we mapped deep brain stimulation sites and looked at whether their structural and functional connectivity profiles could inform clinical outcomes in cervical vs. generalized dystonia.
Jul 22, 2021 • 38 tweets • 28 min read
Delighted to share our review on connectomic DBS for OCD spearheaded by @BaldermannJC out in @BiologicalPsyc1 now. This is likely the most significant clinical-translational achievement I've had the privilege to play a part in, yet.

biologicalpsychiatryjournal.com/article/S0006-…

A thread:🧵 It all started in Cologne ~2018 where @BaldermannJC was the first to use the novel DBS fiberfiltering technique we had developed for @leaddbs on a dataset of 22 persons with OCD that underwent DBS in their center.