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Ben H Profile picture
Ben H
@benh_mecfs
ME/CFS patient advocate, @OpenMedF science correspondent. Bedbound. Former: biochemist in training, Powerlifter, PT, Gym Manager. Jazz grad/Musician. F1/Boxing.
Jan 23, 2023 • 26 tweets • 5 min read
Video on Part 2 of the Itaconate Shunt! #MECFS

I have done a breakdown below.

Joint effort between Rob Phair, Chris Armstrong+Ron Davis and respective groups.

Part 2 is the immunology part-named IFNa-Itaconate shunt now!



@JanetDafoe @OpenMedF

1/24 Ron calls this an ‘immuno-metabolic’ hypothesis.

Begins with summary of Itaconate Shunt part 1—please watch the video for this if able.

Leads to Part 2-beginning with the Innate Immune trigger. It’s the innate immune system that triggers the Itaconate shunt.

2/24
Jan 22, 2023 • 4 tweets • 2 min read
Kinda bizarre. I rarely see fear-mongering, simply serious post-COVID-19 sequelae mentioned as a very real outcome, based on literature and fact.

If that is an uncomfortable, so be it…but it doesn’t make it any less real. #LongCovid ‘…so should all of us who have had covid just sit around and worry about our potential permanent future health issues?’

-Maybe not worry but be mindful, certainly.

That way people will be informed about any complications or co-morbidities that can occur post-infection.
Jul 12, 2022 • 12 tweets • 3 min read
New video below on the Itaconate Shunt ME/CFS hypothesis with Robert Phair and @JanetDafoe!

I've created a thread with some of the basic points:

1/12 Itaconate shunt

ME/CFS hypothesis by @RDPhair, Ron Davis and @C_W_Armstrong. 2/12 Based on a proposal of bistability/on-off switches in amino acid metabolism. Prior research by Chris Armstrong showing ME/CFS patient's metabolism preferentially favouring amino-acids over glucose and fatty acids.
Sep 4, 2021 • 8 tweets • 2 min read
@OxMEDiscovery
1/7
 From the Morten Group at Oxford:

"Our ME/CFS Raman diagnostic paper is just back from review. They like it! But we need to run a further set of expts with new blood samples. Really important we get the PhD funded in order to collect new bloods." 2/7
 "In this proposal we will explore this association in detail in ME/CFS, Chronic Lyme and Long Covid examining not only the gut but also the currently unexplored blood biome."
Mar 29, 2021 • 23 tweets • 9 min read
New research update video with Prof. Ron Davis, March 29th 2021.

Huge thanks again to Ashley Haugen @AshleyHaugen88 for her hard work doing this, also to Ron and Janet.



@JanetDafoe
@DafoeWhitney
@CFSRC

#MECFS For patients that cannot watch or listen, I did a (rough) transcript below:
Mar 11, 2021 • 5 tweets • 4 min read
Responded. The best I could do at the moment. Thanks to @TomKindlon, @wilshica and @Huisarts_Vink for the literature. See response below. #MECFS #2 #MECFS
Mar 11, 2021 • 4 tweets • 1 min read
"We have now done proteomics (the large-scale study of proteins) and metabolomics (an analysis of the metabolism) in cerebrospinal fluid (CSF) and blood plasma from about 40 Intensive Care Unit COVID-19 patients. "

#MECFS "Our next step will be the large-scale metabolomic study of plasma from a larger cross-section of less severe COVID-19 patients (where we have no possibility to collect CSF) not admitted into the ICU."