In December, the @American_Heart published a Presidential Advisory statement on working against structural racism and health disparities in response to recent news events and #BLM advocacy. #healthequity #CQOSpotlight

ahajournals.org/doi/10.1161/CI… The writing committee on behalf of the @American_Heart in the second sentence of the abstract cite COVID-19, George Floyd, Breonna Taylor as recent examples of structural racism, health disparities for disenfranchised groups.

It is interview season for medical fellowships and I thought I would take the time to discuss some of the issues I see come up recurrently in evaluating applicants, especially in dedicated physician-scientist research programs. I am fortunate to have graduated from @UCLA ’s STAR program which feel is an incredible model for training physician-scientists.

The Pandemic Claims New Victims: Prestigious Medical Journals via @NYTimes ⁦@RoniNYTimes⁩ nytimes.com/2020/06/14/hea… @NEJM

How did Surgisphere generate the publication data? To simulate each observation (n=96,032) he'd have to know how to distribute all the characteristics and adjust them as needed.

@mikejohansenmd @NEJM @TheLancet There is more evidence of falsification with this figure. @ADAlthousePhD will provide more details in the morning on the variance estimates. @mikejohansenmd @NEJM @TheLancet @ADAlthousePhD Now look at the reference group 0-10: the figure claims that 11-20 and 21-30 year-olds have a lower risk of death relative to kids <10. Well if that’s true it should be the headline of the @NEJM study.

Let me take us all on a magical walk through the @Surgisphere "revision" and explanation given to the @lancet. Not everything looks like what it seems. I would hope @richardhorton1 would have pushed for better explanations. Let us start with the correction statement. One hospital from Australia should have been in Asia. Not sure why a hospital a company sold a product to would need to self-identify for a cloud-based data analytics platform:

Estimating the burden of SARS-CoV-2 in France science.sciencemag.org/content/early/… @ScienceMagazine "The overall probability of death among those infected (the Infec-tion Fatality Ratio, IFR) is 0.7% (95% CrI: 0.4–1.0), ranging from 0.001% in those under 20ya to 10.1% (95% CrI: 6.0–15.6) in those >80ya (Fig. 2D and table S2)."

This is a thread about the @stanford research group that has led the Santa Clara/Los Angeles @lapublichealth serology studies. I want to highlight the importance of content expertise and biases of personal beliefs. Who was involved in these studies and how were they performed?
Links to pre-prints:
medrxiv.org/content/10.110…

The second seemed to be leaked on @RedState than removed.
dropbox.com/s/pk7nu9gz0vhg…

@DavidLBrownMD @BobDreyfuss2017 @iamritu @mad_sters @ProfDFrancis @rallamee @DrJHoward @mshunshin @MikeTPhD @drjohnm @rwyeh @imperialcollege Yeah, analysis does not adjust for changes in diagnostic sensitivity over time. We have trials included that span 1992 to 2019 and diagnostic criteria were likely more sensitive for inclusion in recent trials. @DavidLBrownMD @BobDreyfuss2017 @iamritu @mad_sters @ProfDFrancis @rallamee @DrJHoward @mshunshin @MikeTPhD @drjohnm @rwyeh @imperialcollege Overall, the meta-analysis doesn't change the predominant dogma that we cannot save lives or prevent cardiac events in a stable CAD population. However, there are situations defined by acute or recent myocardial injury/infarction that benefit from revascularization with PCI.

TGIF: I have a @CircOutcomes #CQOSpotlight on a simulation study evaluating the impact of clinic-based processes to achieve Million Hearts 2022 goals. @CircOutcomes @mad_sters @bnallamo @thebyrdlab @KBibbinsDomingo @CircAHA @jordanbking @markjpletcher @ValyFontil @ADAlthousePhD Manuscript was originally published in June 2019. I just needed some time to get myself organized. Link is here: ahajournals.org/doi/10.1161/CI…

Thread on the reporting of hierarchical outcomes inspired by 1 of the only 2 #Impella RCTs. A few months ago, @willsuh76 noted that rates of bleeding were not reported in PROTECT-II, a worry with any large bore percutaneous device.

This month I revisit #COURAGE. The ultimate conversation starter among @JAMAInternalMed readers and interventional cardiologists. #CQOSpotlight

Quick someone tweet a concerning angiogram cine and ask if anyone else would refer a specific stable CAD patient to OMT!! 𝗕𝗮𝗰𝗸𝗴𝗿𝗼𝘂𝗻𝗱: The #COURAGE investigators provide longer survival follow-up on subset of the original study cohort to evaluate how the number of coronary lesions vs. amount of ischemia is prognostic for patients with stable CAD. ahajournals.org/doi/10.1161/CI…