Hey #IBD folks on generic drugs - check out the GI meds at @costplusdrugs (A PBC) - Canasa, mesalamine, esomeprazole available at reasonable prices. Hoping that budesonide and biosimilars (adalimumab, infliximab) are next. Fewer patients driving to Canada? costplusdrugs.com/medications/ for folks asking what is a PBC - Public Benefit Corporation - kiplinger.com/investing/esg/…

When a new drug is approved in your field, it is a good practice to go through the prescribing information in detail. There is a *lot* to unpack in the #Ozanimod PI. Let's take a tour (THREAD) First, *before prescribing*, there are 7 required assessments in section 2.1.
1⃣ recent CBC with lymphocyte count
2⃣ recent LFTs
3⃣ EKG to rule out long QT, heart block, sick sinus
4⃣ Eye exam if prior uveitis, macular edema
5⃣ Washout of prior immunosuppressive drugs...

THREAD: This year’s #shotwave tweet is unusual. Not about a flu shot (though I got one back in September). This year I am participating in a randomized, controlled trial with my mom. We are both enrolled in a #COVID-19 vaccine trial. 1/15 @DrsMeena #StandBackImGoingToTryScience We enrolled on day 1 at our University of Michigan site, in the Michigan Clinical Research Unit (MCRU), where I enroll and see a lot of #IBD patients participating in clinical trials. #IBD patients (on immunosuppression +/- steroids) would not be eligible for this study. 2/15

THREAD: More data about PPIs and SARS-CoV-2 coming out. Is there a consistent association across studies? @statsepi @DrToddLee @supermarioelia @mikejohansenmd @ADAlthousePhD Increased prevalence of ARDS in those taking PPI at baseline: onlinelibrary.wiley.com/doi/full/10.11… prior use of PPIs associated with higher rate of death in COVID-19 infected patients. medrxiv.org/content/10.110…

@MaartenvSmeden @AllonKahn @georgemsavva @IBDMD @ADAlthousePhD @doctorira @tmorris_mrc @BrennanSpiegel @NYUDocs @statsepi There is some very weird stuff going on in this sample (as pointed out in the open letter), and given the high response rate to an online survey, lots of hard questions need to be asked of CINT (the survey company) about how they get respondents. @MaartenvSmeden @AllonKahn @georgemsavva @IBDMD @ADAlthousePhD @doctorira @tmorris_mrc @BrennanSpiegel @NYUDocs @statsepi I worry about the data source more than the analysis (though people certainly can make coding/labeling errors, and data/code repositories and code review are helpful). I can imagine a lower rate of respondents >60yo in an online survey. And maybe low rate of GERD depending...

This Saturday, May 2nd, will be a little sad for me. I (and about 13,000 of my GI friends) would have been in Chicago for @DDWMeeting. That won't happen. So I decided (with a few friends) to have a get-together. A #TotallyUnofficial "Poster Rounds". In a webinar format over 1 hour, at 3PM EDT, noon PDT, 8 PM UK time, 9 PM CET, with informal presentations and discussion of 4 posters. We will have two posters that would have been presented at the meeting, and two "late breakers"/works in progress.

Questions today about the risk of coronavirus nCoV-19 in #IBD patients on immunosuppressive therapies. We don't know a lot, as this is quite new. The most up-to-date information can be found at the CDC website cdc.gov/coronavirus/20… It appears to be spread by respiratory droplets, generally when you inhale droplets from a cough or sneeze from a nearby person (usually within 6 feet). Do #IBD patients have increased risk for this respiratory virus?